Use of saffron against dementia in Traditional Persian Medicine: A historical perspective

Marzabadi, Leila Rasi

doi:10.14744/etd.2021.89248

Cited by 1 publication

(1 citation statement)

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“…C. sativus is among the most treasured spices in the world with a long history in traditional Persian medicine (Mousavi & Bathaie, 2011; Mzabri, Addi, & Berrichi, 2019; Rasi Marzabadi et al, 2021). Several medical and pharmacological effects of saffron have been reported for different conditions including hypertension, ischemia, tumors, depression, liver disease, menstruation disorders, as well as obesity (Agha‐Hosseini et al, 2008; Ayati, Yang, Ayati, Emami, & Chang, 2020; Bolhassani, Khavari, & Bathaie, 2014; Mancini et al, 2014; Mashmoul et al, 2016; Saleem et al, 2006; Shafiee, Arekhi, Omranzadeh, & Sahebkar, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta‐analysis of randomized controlled trials

Tahmasbi

Araj‐Khodaei

Mahmoodpoor

et al. 2022

Phytotherapy Research

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The worldwide prevalence of obesity is approximately tripled between 1975 and 2016 according to World Health Organization; therefore, obesity is now considered a global pandemic that needs academic and clinical focus. In search of antiobesity agents, Crocus sativus, known widely as saffron, has been praised for its beneficial effects. Several randomized controlled trials (RCTs) have been conducted to investigate the weight lowering effect of saffron. Following PRISMA guidelines, several medical databases were comprehensively searched for RCTs with a population consisting of obese individuals. A random‐effects meta‐analysis was used to pool estimates across studies, and standardized mean difference (SMD) was used to synthesize quantitative results. Twenty‐five RCTs met the inclusion criteria. Meta‐analysis showed a nonsignificant decrease for weight (−0.32 kg; CI: −3.15, 2.51; p = 0.82), BMI (−0.06 kg/m2;CI:‐1.04,0.93; p = .91), waist circumference (−1.23 cm; CI: −4.14, 1.68; p = .41), and hip circumference (−0.38 cm; CI: −5.99, 5.23; p = .89) and a significant decrease of waist‐to‐hip ratio (SMD = −0.41; CI: −0.73, −0.09; p = .01; I2 = 0%). The mean difference in fasting blood sugar showed a significant reduction in patients with metabolic syndrome (SMD = −0.30; 95% CI: −0.63, 0.03; p = .07; I2 = 0.37%) but a nonsignificant change in the HbA1C level (WMD = 0.05; 95% CI: 0.32, 0.41; p = .79). Despite bearing several limitations, mainly as a result of heterogeneity among included studies, the available evidence indicates saffron supplementation shows promising effects on some cardiometabolic factors among overweight to obese patients; however, further investigations and high‐quality evidence are required for more generalizable and comprehensive results.

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Section: Introductionmentioning

confidence: 99%

Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta‐analysis of randomized controlled trials

Tahmasbi

Araj‐Khodaei

Mahmoodpoor

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

Use of saffron against dementia in Traditional Persian Medicine: A historical perspective

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as: Marzabadi LR,

Cited by 1 publication

References 25 publications

Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta‐analysis of randomized controlled trials

Effects of saffron (Crocus sativus L.) on anthropometric and cardiometabolic indices in overweight and obese patients: A systematic review and meta‐analysis of randomized controlled trials

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