Use of Saponinosomes from <i>Ziziphus spina-christi</i> as Anticancer Drug Carriers

Nazemoroaya, Zahra; Sarafbidabad, Mohsen; Mahdieh, Athar; Zeini, Darya; Nyström, Bo

doi:10.1021/acsomega.2c03109

Cited by 14 publications

(5 citation statements)

References 56 publications

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“…The peak of 1036.65 cm −1 refers to the C-O stretches of holocellulose and lignin [ 81 ], which may come from ether and phenol [ 12 ], or the carboxylic and alcohol groups [ 86 ], and can also be attributed to the linkage absorption C-O-C [ 87 ] to oligosaccharide present in the structure of saponin [ 27 , 88 ], assuming that this substance has not been completely removed by contact with 0.5 N NaOH, as the alkaline treatment generally induces extensive modifications in the polysaccharides [ 89 , 90 ]. After contact with Pb(II) ions, the enlargement and increase in intensity of this region can be noticed.…”

Section: Resultsmentioning

confidence: 99%

Pb(II) Ion Removal Potential in Chemically Modified Ziziphus joazeiro Barks

Santos

Costa²,

Menezes

et al. 2022

IJERPH

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In this study, five types of modified Ziziphus joazeiro barks were investigated for the removal of Pb(II) ions from aqueous solutions. The samples tested were natural barks, natural powder, washed with water, ethanol at 80% (EE) and 0.5 N NaOH. Batch kinetics experiments were performed under the conditions: 24–25 °C, pH 5.5–5.8, 102 mg·L−1 Pb(NO3)2, 100 rpm and 0.1 g of adsorbent, and analyses of pHpzc and Fourier transform infrared spectroscopy. All adsorbents tested showed potential to remove Pb(II) ions, but the adsorbent washed by 0.5 N NaOH obtained the highest experimental performance (25.5 mg·g−1 at 30 min), while the EE had the least performance (20.4 mg·g−1 at 60 min), and maximum removals of 99.9%. The kinetic models pointed to a probable chemisorption due to the best fit of pseudo-second order and Elovich, and Boyd’s model, suggesting that intraparticle diffusion limits the adsorption until the initial minutes of contact. The Langmuir isotherm fitted better to the experimental data for the NaOH adsorbent, with maximum adsorption capacity equal to 62.5 mg·g−1, although the Temkin model partially fitted, both suggesting the occurrence of chemisorption. The adsorption process is reversible (>81% at 20 min) and hence the adsorbents can be recycled and the Pb(II) ions recovered.

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Section: Resultsmentioning

confidence: 99%

Pb(II) Ion Removal Potential in Chemically Modified Ziziphus joazeiro Barks

Santos

Costa²,

Menezes

et al. 2022

IJERPH

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“… 32 Zizyphus Spina containing saponin disrupts the cell wall of Candida albicans. 33 Additionally, Zizyphus Spina has endophytic A. Alternaria, which has potent antioxidant activity that can cause cell membrane disruption. 34 Finally, the tannins in Zizyphus Spina, by eliminating Iron, reduce the pathogen growth and proliferation.…”

Section: Discussionmentioning

confidence: 99%

The effects of Ziziphus Spina leaves’ Hydro-Alcoholic Extract Vaginal Cream and Clotrimazole on Candida albicans in Wistar Rats

Honarmandpour

Fatahinia

Keshavarzzade

et al. 2022

Clin Med�Insights�Pathol

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Background: In vitro, Ziziphus Spina-Christi (ZSC) leaves have been shown to have antimicrobial and antifungal effects. This study aimed to examine the effects of Ziziphus Spina leaves hydro-alcoholic extracts with Clotrimazole against Candida albicans in female rats. Methods: Four groups of rats were infected vaginally with C. Albicans, and 1 group not infected was considered negative control. The infected groups received the following treatments: 2 groups were treated with vaginal 5%, or 10%, of Ziziphus Spina extract creams. One group received 1% clotrimazole, and 1 group did not receive any treatment considered a positive control. Results: The mean number of colony-forming units (CFUs) before the intervention was 195.83 ± 395.126 in the 5% ZSC group, 346.33 ± 396.719 in the 10% ZSC group, 345.17 ± 507.431 in the clotrimazole group, 212.20 ± 148.304 in the positive control group ( P = .604), and 0 in the negative control group ( P = .003). After 1 week, the average number of CFUs considerably dropped to 65.14 ± 36.03 in the 5% ZSC group, 1.43 ± 3.60 in the 10% ZSC group, and 0.43 ± 1.13 in the clotrimazole group. The number in the positive control group remained unchanged (212.20 ± 148.304) ( P = .005). After 2 weeks, the average number of CFUs was 0 in the 10% ZSC group, Clotrimazole and negative control groups and was 4.57 ± 23.99 in the 5% ZSC group ( P < .001). Conclusions: Our findings indicated that the effectiveness of Vaginal creams containing 10% Ziziphus Spina is similar to Clotrimazole in eliminating C. Albicans.

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“…There is a growing interest between researchers and pharmaceutical production in enhancing the delivery and improving the bioavailability of drugs to improve their therapeutic efficacy. Particularly, the self-assembly approach holds great promise for designing effective delivery systems. , Liposomes are one of the drug delivery systems that are frequently used as a carrier for the lipophilic and hydrophilic antioxidant agents to evaluate their antioxidant activities . Moreover, liposomes are also used as an efficient delivery system for water-soluble (e.g., glutathione, N-acetylcysteine, and quercetin) and lipid-soluble (e.g., tocopherol and CoQ10) antioxidant medicines to various organs and tissues for the treatment of oxidative stress-associated damage. − Recently, there has been a growing interest in exploring innovative approaches to enhance drug delivery systems for improved bioavailability and therapeutic efficacy. , Among these approaches, the incorporation of bioactive compounds into the structure of liposomes has gained significant attention .…”

Section: Introductionmentioning

confidence: 99%

“…Particularly, the self-assembly approach holds great promise for designing effective delivery systems. 4 , 5 Liposomes are one of the drug delivery systems that are frequently used as a carrier for the lipophilic and hydrophilic antioxidant agents to evaluate their antioxidant activities. 6 Moreover, liposomes are also used as an efficient delivery system for water-soluble (e.g., glutathione, N-acetylcysteine, and quercetin) and lipid-soluble (e.g., tocopherol and CoQ10) antioxidant medicines to various organs and tissues for the treatment of oxidative stress-associated damage.…”

Section: Introductionmentioning

confidence: 99%

Liposome Nanocarriers Based on γ Oryzanol: Preparation, Characterization, and In Vivo Assessment of Toxicity and Antioxidant Activity

Jasim,

Albukhaty,

Sulaiman

et al. 2024

ACS Omega

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The present study aimed to develop and characterize liposome nanocarriers based on γ oryzanol and evaluate their potential in vitro and in vivo toxicity and antioxidant effects. The liposomes were physicochemically characterized using various techniques, including dynamic light scattering (DLS) for size and polydispersity index (PDI) measurements and ζ-potential analysis. The in vitro toxicity assessments were performed using hemolysis and MTT assays on the HS5 cell line. In vivo, acute oral toxicity was evaluated by using LD 50 assays in mice. Additionally, antioxidant activity was assessed through biochemical analysis of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and liver tissue catalase, malondialdehyde (MDA), and glutathione (GSH) levels. The results revealed that the liposomes exhibited a uniform and spherical morphology with suitable physicochemical properties for drug delivery applications. The in vitro cytotoxicity and hemolysis assays and the in vivo LD 50 experiment indicated the potential safety of γ oryzanol liposomes, especially at lower concentrations. In addition, the assessment of liver enzymes, i.e., ALT and AST, and the antioxidant markers further revealed the safety of the formulation, particularly for the liver as a highly sensitive soft organ. Overall, the liposome nanocarriers based on γ oryzanol were successfully formulated and expressed potential safety, supporting their application for the purposes of drug delivery and therapeutic interventions, particularly for hepatocellular and antioxidant therapies; however, further investigations for preclinical and clinical studies could be the future prospects for liposome nanocarriers based on γ oryzanol to explore the safety and efficacy of these nanocarriers in various disease models and clinical settings.

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Use of Saponinosomes from Ziziphus spina-christi as Anticancer Drug Carriers

Cited by 14 publications

References 56 publications

Pb(II) Ion Removal Potential in Chemically Modified Ziziphus joazeiro Barks

Pb(II) Ion Removal Potential in Chemically Modified Ziziphus joazeiro Barks

The effects of Ziziphus Spina leaves’ Hydro-Alcoholic Extract Vaginal Cream and Clotrimazole on Candida albicans in Wistar Rats

Liposome Nanocarriers Based on γ Oryzanol: Preparation, Characterization, and In Vivo Assessment of Toxicity and Antioxidant Activity

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