“…This method uses permissive hypercapnia to provide ventilatory support and maintain normal cellular function, allowing PaCO 2 to rise while maintaining an arterial pH between 7.25 and 7.30. This strategy minimizes VILI, reduces the incidence of secondary chronic lung disease, improves ventilation/perfusion (V/Q) mismatch, does not impair cardiac output, and improves lung recruitment without overdistension [1, 4, 5, 9, 11, 13, 17, 18, 25, 26, 30, 31, 34, 40, 42].…”