Use of sodium salt of Carbopol 934P in oral peptide delivery

Nakanishi, Takeshi; Kaiho, Fusao; Hayashi, Masahiro

doi:10.1016/s0378-5173(98)00176-8

Cited by 15 publications

(7 citation statements)

References 13 publications

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“…In the realm of pharmaceutical formulation, several polyelectrolytes (PE) carrying acidic groups are currently used, mainly as suspending or viscosity‐increasing agents in liquid and semisolid formulations1 as well as in components of solid matrices 2–4. Although less attention has been given to the use of acidic PE as carriers of basic drugs, there is increasing interest in their application in this field 5–9.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Lidocaine Release From Carbomer–Lidocaine hydrogels

Jiménez-Kairuz

Allemandi

Manzo

2002

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Mechanism of Lidocaine Release From Carbomer–Lidocaine hydrogels

Jiménez-Kairuz

Allemandi

Manzo

2002

Journal of Pharmaceutical Sciences

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“…Porosity can be controlled by controlling the following process variables: type of polymer, amount of polymer, and speed of rotation. Carboxyl groups in the polymer CP934P bind more strongly with the oligosaccharide chains of mucin owing to hydrogen bonding, and thus, mucoadhesive force is enhanced (38,39). The study of ex vivo mucoadhesion in Wistar rat confirmed that most of the formulations had good mucoadhesive strength in two different pH values (simulated gastric fluid (SGF) and simulated intestinal fluid (SIF)).…”

Section: Characterization Of Microparticlesmentioning

confidence: 68%

Study of the Mucoadhesive Potential of Carbopol Polymer in the Preparation of Microbeads Containing the Antidiabetic Drug Glipizide

2015

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Abstract. The present investigation was aimed at exploitation of the mucoadhesive potential of carbopol 934P polymer in developing microbeads of glipizide (GLP) for its effectivity in controlling blood sugar in diabetic patients. Various batches of GLP beads were prepared by an emulsion-solvent evaporation technique using the release-retarding polymer carbopol and subjected to a systematic evaluation such as physical characterization, ex vivo mucoadhesion, hydration and erosion test, and in vitro drug release; and instrumental and in vivo studies were performed with the best formulation. The highest yield and loading efficiency were observed as 94 and ∼90%, respectively. The mean particle size of the microbeads ranged from 832 to 742 μm. The oval shape of the microbeads with slight roughness was apparent in the SEM micrograph. The release period was extended till 18 h. In vitro release of the drug from the beads followed the diffusion and erosion mechanism. In the oral glucose tolerance test (OGTT), there is a significant (p<0.01) reduction in fasting blood glucose levels in Wistar rat and guinea pig in comparison with that using the marketed product. Results indicated that process parameters-drug-polymer ratio, concentration of the surfactant, and stirring speed-controlled the various characteristics of the microparticles. The mucoadhesivity test ensured strong adherence of the beads to the mucosal membrane in pH 1.2 for a prolonged period. Owing to the mucoadhesivity of carbopol 934P, prolonged release of GLP and reduction of fasting sugar in the animal model were observed to a satisfactory level, and thus, management of diabetes in a better manner is expected with this new formulation.

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“…The pieces of mucosa were stored frozen in phosphate buffer with pH 7.4 and thawed to room temperature before use. 11 At the time of testing, a section of mucosa was attached to the upper glass vial (C) using a cyanoacrylate adhesive (E). The diameter of each exposed mucosal membrane was measured to be 1.5 cm.…”

Section: Bioadhesion Strengthmentioning

confidence: 99%

“…3). According to in vitro mucoadhesion test run by Nakanishi et al, 11,15 the mucoadhesion force depends on the hydrogen bonding between the hydroxyl group in the polymer and the mucus. It forms an ionic complex with hyaluronic acid that provides higher binding power.…”

Section: Pharmaceutical Sciences September 2015 21 102-110 | 107mentioning

confidence: 99%

Fast Dissolving Oral Thin Film Drug Delivery Systems Consist of Ergotamine Tartrate and Caffeine Anhydrous

Jelvehgari¹,

Montazam²,

Soltani³

et al. 2015

Pharm Sci

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Background: Ergotamine tartrate (ET), a serotonin 5-HT1 receptor agonist, is an antimigraine drug. Due to high first-pass metabolism, ET shows a very low bioavailability in oral administrations (<1%). Caffeine (CA) increases the rate and extent of water solubility of ET. The present study intended to investigate the possibility of developing ET fast dissolving thin films for the fast drug dissolution in the oral cavity, and thus bypassing first pass metabolism for providing quick onset of action of the drug. Methods: The films (ET and CA) were prepared according to solvent casting method, separately. Low viscosity grade of hydroxylpropyl methylcellulose (HPMC E-15) was employed in preparation as a film forming polymer. Propylene glycol was the plasticizer used. All the films were evaluated for their thickness, weight variations, folding endurance, surface pH, disintegration, drug content, DSC, in-vitro drug release, and ex-vivo permeation. Results: The best polymer drug ratio in ET/CA films was 1:20 (E 2) and 1:4 (C 2), respectively. The films E 2 and C 2 showed 9.9, 3.2 mg weight, 74, 45 µm thickness, 120.66, up to 300 folding endurance and 0.38, 0.52 mg/cm 2 drug content, respectively. The DSC showed no stable characteristic for ET and CA in the drug loaded films and revealed amorphous form. The results showed that ET films prepared had faster release and CA films had slower release (p

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Use of sodium salt of Carbopol 934P in oral peptide delivery

Cited by 15 publications

References 13 publications

Mechanism of Lidocaine Release From Carbomer–Lidocaine hydrogels

Mechanism of Lidocaine Release From Carbomer–Lidocaine hydrogels

Study of the Mucoadhesive Potential of Carbopol Polymer in the Preparation of Microbeads Containing the Antidiabetic Drug Glipizide

Fast Dissolving Oral Thin Film Drug Delivery Systems Consist of Ergotamine Tartrate and Caffeine Anhydrous

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