Use of somatostatin analogues in the pancreonecrosis therapy (kliniko-experimental research)

Agapov, K. V.; Шутов, А. А.; Polyvoda, M D; Pavlov, Nikolay; Bagdatieva, M G

doi:10.17116/hirurgia20161271-76

Cited by 1 publication

(3 citation statements)

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“…Sepsis is known to be a critical state associated with endogenous intoxication which causes mitochondrial dysfunction, triggers the mechanisms of apoptosis and immunodepression [19,22,[29][30][31]. The complex of these pathogenic mechanisms is maintained and regulated by the mediators of systemic inflammation, coagulation, reprogramming of immunocompetent cell genes, and disorders of physiological functions and organ activity in this case go beyond the limits of regulatory capabilities to such an extent that the function regulation systems are not able to correct spontaneously and demand partial or complete replacement (prosthetic treatment) [31][32][33][34][35][36].…”

Section: Reviewsmentioning

confidence: 99%

“…Intoxication can be maintained by the formation of supermolecular biological compounds between the microorganism elements and products of the native tissue decomposition [32,[34][35][36].…”

Section: Reviewsmentioning

confidence: 99%

“…Increased concentration of end or intermediate products of normal metabolism, pathological shifts in electrolyte balance also cause toxic effect [ 34 , 36 ].…”

Section: Appropriateness Of Using Hemofiltration In Patients With Severe Acute Pancreatitismentioning

confidence: 99%

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Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

et al. 2020

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Questions regarding the application of extracorporeal detoxification to patients with severe acute pancreatitis have been considered. Hemodialysis, the historically first method of extracorporeal detoxification for such patients, has been also described in the review. Appropriateness of using renal replacement therapy methods and among them continued renal replacement therapy has been shown. Hemofiltration and hemodiafiltration technologies are described in detail including different modes of their application and the possibility of using various types of filters. Available data on hemofiltration for patients with severe acute pancreatitis have been analyzed. Great attention is paid to the unsolved aspects of hemofiltration in severe acute pancreatitis such as determining renal and extrarenal indices; time of starting hemofiltration; selection of volume replacement modes and a buffer system; procedure duration; anticoagulation measures, defining criteria to assess the adequacy of hemofiltration, state severity, and organ dysfunction degree. Further multicenter investigations are necessary to be able to assess the efficacy of the hemofiltration procedures on the basis of the thoroughly worked out and pathogenically grounded protocol using adequate control methods taking into consideration endogenic intoxication phases and intensity of the multiple organ failure syndrome.

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Section: Reviewsmentioning

confidence: 99%

“…Intoxication can be maintained by the formation of supermolecular biological compounds between the microorganism elements and products of the native tissue decomposition [32,[34][35][36].…”

Section: Reviewsmentioning

confidence: 99%