Use of standardized uptake value thresholding for target volume delineation in pediatric Hodgkin lymphoma

Abstract

Accurate target volume delineation with [(18)F] 2-fluoro-2-deoxy-d-glucose PET in HL is challenging and may require more precise and reproducible segmentation methods as we move toward more conformal therapies.

A Formula to Calculate the Threshold for Radiotherapy Targets on PET Images: Simulation Study

“…In this work, 88704 acquisitions covering all clinical situations were undertaken, and continual change of the threshold with tumor size was proposed. The reported discrete results (6,7,(10)(11)(12)(13)(14)(15)(16)(17)(18) were covered in the change rule.…”

“…Nevertheless, because of the influence of the partial volume effect (PVE), tumor boundaries on PET images are blurred and the exact size of a tumor cannot be defined precisely. How to determine tumor boundaries and delineate the biologic target of a tumor has been an important focus of research (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Bearing this in mind, we undertook a computer-simulation study on various imaging parameters that might be encountered when conducting imaging with different device performances under various clinical situations.…”

PET Scan in Hodgkin Lymphoma

“…There was a clinically significant decrease in dose to normal structures when the involved site radiation therapy (ISRT) plans were generated using the 15 % ΔSUV max × volumes compared with the 40 % ΔSUV max [171]. Automatic or semiautomatic segmentation methods including thresholding based on a percent tumor ΔSUV max may decrease variability in tumor delineations, but there is limited data in lymphoma using tumor volume segmentation methodologies.…”