Use of statins and the incidence of type 2 diabetes mellitus

Abstract

Use of statins and the incidence of type 2 diabetes mellitUs rev Assoc med BrAs 2015; 61(4):375-380 375

Effect of statins on fasting glucose in non-diabetic individuals: nationwide population-based health examination in Korea

“…Due to there are pathophysiologic and epidemiologic data for a linkage between hyperglycemia and increased cardiovascular or all-cause mortality in diabetic and non-diabetic patients, physicians should be cautious about the potential risk of statin-mediated hyperglycemia and new-onset DM [ 32 , 33 ]. To maintain the cardiovascular benefit and minimalize the potentially adverse hyperglycemic effect with statins, multi-strategy approach should be considered, including monitoring of fasting glucose, control of predisposing factors to glucose intolerance and unhealthy life-style, proper selection of the statin (type and dosage) and concomitant medications [ 21 , 34 ]. Screening and risk stratification for diabetes on the initiation of statins and periodical monitoring of fasting glucose would be helpful for early diagnosis and proper glucose control in patients on statin therapy [ 33 , 35 ].…”

“…The discrepancy could be originated from difference in baseline characteristics of study population, coexisting risk factors, follow-up duration, medication adherence and so on. It is known that statin-induced DM risk is higher in pre-diabetes and patients with predisposing factors for DM such as old age and obesity [ 34 ]. The short-term and long-term effects on glucose metabolism may be different in accordance with type of statins and underlying characteristics of patients [ 70 ].…”