Use of Stem Cells for Liver Diseases—Current Scenario

Kumar, Ashish; Pati, Nirupma; Sarin, Shiv Kumar

doi:10.1016/s0973-6883(11)60114-x

Cited by 11 publications

(10 citation statements)

References 91 publications

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“…Chronic liver diseases (CLD) represent a serious public health problem in the world. Continuous hepatic injury may result in alterations in liver repair processes, characterized by progressive formation of tissue fibrosis and changes in angiogenic architecture 1,2 . It is known that a variety of cell types and soluble mediators are involved in the course of CLD, integrating inflammatory processes, fibrosis and extracellular matrix components (ECM) remodeling 3 .…”

Section: Introductionmentioning

confidence: 99%

Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice

Souza

Moura

Castro

et al. 2019

Sci Rep

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Liver diseases are a major health problem worldwide leading to high mortality rates and causing a considerable economic burden in many countries. Cellular therapies as potential treatments for liver diseases have proven beneficial in most of the conditions. In recent years, studies involving therapy with bone marrow cells have been implemented to promote liver regeneration and to reduce hepatic fibrosis, however identifying the cell population present in the bone marrow that is responsible for hepatic improvement after therapy is still necessary. The aim of the present study was the evaluation of the therapeutic efficacy of monocytes obtained from bone marrow in fibrosis resulting from S . mansoni infection in C57BL/6 mice. Monocytes were isolated by immunomagnetic separation and administered to the infected animals. The effects of treatment were evaluated through morphometric, biochemical, immunological and molecular analyzes. Monocyte therapy promoted reduction of liver fibrosis induced by S . mansoni infection, associated with a decrease in production of inflammatory and pro-fibrogenic mediators. In addition, monocyte infusion caused downregulation of factors associated with the M1 activation profile, as well as upregulation of M2reg markers. The findings altogether reinforce the hypothesis that the predominance of M2reg macrophages, producers of immunosuppressive cytokines, may favor the improvement of hepatic fibrosis in a preclinical model, through fibrous tissue remodeling, modulation of the inflammatory response and fibrogenesis.

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Section: Introductionmentioning

confidence: 99%

Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice

Souza

Moura

Castro

et al. 2019

Sci Rep

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“…However, these reports are diverse in terms of their clinical trial design, types of infused cells, patient groups, and efficacy of therapies. In the present study, we address the recent review articles from these viewpoints, and clarify their significance. Examination was carried out according to the classification of cell sources such as MSCs, HSCs, BMCs, and other cells.…”

Section: Clinical Application Of Stem Cell‐based Therapy For Liver DImentioning

confidence: 92%

“…Many review articles concerning stem cell therapies for liver diseases, which have been carried out in clinical settings, have been reported . However, their descriptions are heterogeneous.…”

Section: Introductionmentioning

confidence: 99%

Progress in stem cell‐based therapy for liver disease

Shiota

Itaba

2016

Hepatology Research

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Liver transplantation has been accepted as a useful therapeutic approach for patients with end-stage liver disease. However, the mismatch between the great demand for liver transplants and the number of available donor organs underscores the urgent need for alternative therapeutic strategies for patients with acute and chronic liver failure. The rapidly growing knowledge on stem cell biology has opened new avenues toward stem cell-based therapy for liver disease. As stem cells have capacity for high proliferation and multipotent differentiation, the characteristics of stem cells fit the cell therapy. Several types of cells have been investigated as possible sources of liver regeneration: mesenchymal stem cells, hematopoietic stem cells, liver progenitor cells, induced pluripotent stem cells, and bone marrow mononuclear cells. In vitro and in vivo experiments revealed that these cells have great potential as candidates of stem cell therapy. We reviewed the reports on clinical trials of cell therapy for liver disease that have been recently undertaken using mesenchymal stem cells, hematopoietic stem cells, bone marrow mononuclear cells, and liver progenitor cells. These reports have heterogeneity of description of trial design, types of infused cells, patient population, and efficacy of therapies. We addressed these reports from these viewpoints and clarified their significance. We hope that this review article will provide a perspective on the available approaches based on stem cell-based therapy for liver disease.

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“…Beside the successful history of tissue engineering techniques to repair certain tissues such as skin, bone and cartilage, more interests were paid during the last few years by different research groups on soft-tissue engineering. This new approach will help to repair and regenerate soft tissues in different organs such as heart, lung and liver [251][252][253].…”

Section: Regenerative Medicine and Stem Cellmentioning

confidence: 99%

Biotechnology for Wellness Industry: Concepts and Biofactories

Sarmidi¹,

Enshasy²

2012

Int J Biotech Well Ind

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One of the major issues in the 21 st. century facing humankind is on how to stay healthy and delay the onset of chronic metabolic diseases. Chronic metabolic chronic diseases still afflict a substantial percentage of modern human population despite the advances in medical and health care technologies. They create a long-term financial burden to the nation as well as reducing the productivity and the quality of life. In the recent years, the wellness approach to healthy living by mean of health enhancement and disease prevention has been increasing in popularity. There is a tremendous global and local interest for wellness products. Wellness sector focuses on providing products and services to a wider community to improve appearance, slow down the effect of ageing and to reduce the risk of developing chronic metabolic diseases. The wellness products are intended for the promotion of health in soil, plants, animals and human. Soil health is the foundation of wellness as healthy and productive soil produce healthy plants and crops in turn produced healthy animals for human nutrition. It is a fact that human health is closely associated with the practice of healthy life style that include consuming wholesome nutrients, living in a non-toxic environment and enhancing physical and mental fitness. These factors in turn promote the attainment and maintenance of cellular homeostasis. Under cellular homeostasis the cellular metabolic activities are at their optimum. In this regard traditional and modern biotechnology offer comprehensive list of natural ingredients and metabolites essential for cellular metabolism. These natural ingredients and metabolites are derived from microbial, algal, plant, animals, and human sources. Most of these natural products are increasingly made available by using innovative bioprocess technologies as more of them are main components of functional foods, nutraceuticals, cosmeceuticals and therapeutics. Bioprocess industries are considered as source for both health and wealth. The new concept of bioprocess industries is based on using different types of cells as small micro-bio-factories. These small biofactories belong to different classes of living organisms ranging from the most primitive prokaryotic bacterial cells up to high eukaryotic human cells. In the present review, the concept of bioprocess design and cultivation of cells up to the industrial level will be presented.

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Use of Stem Cells for Liver Diseases—Current Scenario

Cited by 11 publications

References 91 publications

Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice

Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice

Progress in stem cell‐based therapy for liver disease

Biotechnology for Wellness Industry: Concepts and Biofactories

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