Use of Subatmospheric Pressure to Prevent Progression of Partial-Thickness Burns in a Swine Model

Morykwas, Michael J.; David, Lisa R.; Schneider, Andrew M.; Whang, Chris; Jennings, Debby A.; Canty, Christy; Parker, Darian; White, Wain L.; Argenta, Louis C.

doi:10.1097/00004630-199901001-00003

Cited by 124 publications

(68 citation statements)

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“…1,7 There is also some experimental evidence that NPWT may reduce the inflammatory infiltrate in both acute and chronic wounds. 2,41,42 Thirty seven burn wounds were treated with NPWT in present series and all but three healed without need for grafting.…”

Section: Discussionmentioning

confidence: 79%

Negative pressure wound therapy: eleven-year experience at a tertiary care hospital

et al. 2017

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Background: Management of complicated wounds is a reconstructive challenge. A reconstructive surgeon has to be ready to face new challenges every day. Negative pressure wound therapy has revolutionized the management of complex wounds. We are presenting our experience with this wound care modality in the past 11 years.Methods: It was a prospective study conducted from January 2006 to December 2016 on patients having wounds of varied etiologies, who consented to participate in this study. Custom made low cost NPWT was used till definitive wound closure.Results: A total of 568 patients consented to participate in the study during these 11 years. No major complications were seen. Most of these were males (60.73%) in their 3rd and 4th decade. Trauma was the leading cause of wounds in 38.14%, followed by diabetic foot wounds in 21.5%. Ankle and foot was the most common site of wounds (30.92%) followed by leg (24.01%). A total of 322 small, 218 medium and 97 large size dressings were used. Most of the patients improved with the NPWT. No major complications were seen.Conclusions: NPWT is safe, effective and has proved to be revolutionary in managing difficult wounds. With the use of customized low cost NPWT the benefit can be extended to underprivileged population in under developed nations too.

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Section: Discussionmentioning

confidence: 79%

Negative pressure wound therapy: eleven-year experience at a tertiary care hospital

et al. 2017

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“…64 Application of antioxidants, bradykinin antagonists, and negative pressure therapies can also improve blood flow and improve outcome for this tissue. 65,66 Inflammation in the zone of stasis also plays a role in determining survival of the tissue by virtue of the effect of these mediators on vasoconstriction. Anti-inflammatory treatment of the zone of stasis immediately after injury improves tissue perfusion and tissue survival in animal models.…”

Section: Burn Progressionmentioning

confidence: 99%

The Burn Wound Microenvironment

Rose

Chan

2016

Advances in Wound Care

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“…[1][2][3][4][5][6][7] Contraindications and Precautions for VAC Therapy. [8][9][10][11][12][13][14][15][16][17][18]  Fistula to organs/body cavities  Dry eschar  Untreated osteomyelitis  Malignancy in wounds  Exposed blood vessels or organs  Long-term anticoagulant therapy  Haemophilia  Haemoglobinopathies, i.e. sickle cell disease.…”

Section: Vac Therapy Indicationmentioning

confidence: 99%

A Prospective Randomized Trial of Vacuum-Assisted Closure Versus Standard Therapy of Chronic Non-Healing Wounds

Raghupathy¹,

Sabrena²,

Vaithiswaran³

et al. 2016

jemds

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BACKGROUNDThe application of controlled levels of negative pressure has been shown to accelerate debridement and promote healing in many different types of wounds. The optimum level of negative pressure appears to be around 125 mmHg below ambient and there is evidence that this is most effective if applied in a cyclical fashion of five minutes on and two minutes off. It is believed that the negative pressure assists with removal of interstitial fluid, decreasing localised oedema and increasing blood flow. This in turn de creases tissue bacterial levels. Additionally, mechanical deformation of cells is thought to result in protein and matrix molecule synthesis, which increases the rate of cell proliferation. Despite the significant costs involved, the technique is said to compare favourably in financial terms with conventional treatments in the management of difficult to heal wounds.

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Use of Subatmospheric Pressure to Prevent Progression of Partial-Thickness Burns in a Swine Model

Cited by 124 publications

References 0 publications

Negative pressure wound therapy: eleven-year experience at a tertiary care hospital

Negative pressure wound therapy: eleven-year experience at a tertiary care hospital

The Burn Wound Microenvironment

A Prospective Randomized Trial of Vacuum-Assisted Closure Versus Standard Therapy of Chronic Non-Healing Wounds

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