2001
DOI: 10.1148/radiology.220.2.r01au30381
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Use of99mTc (V) DMSA Scintigraphy in the Detection and Localization of Intestinal Inflammation: Comparison of Findings at Colonoscopy and Biopsy

Abstract: Our results show that 99mTc (V) DMSA scintigraphy is a useful noninvasive diagnostic test for the detection and localization of intestinal inflammation.

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Cited by 26 publications
(20 citation statements)
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“…The exact mechanism of the extrarenal uptake is unclear with regard to pathology. Although a pentavalent (V)-DMSA scan is useful in the scintigraphic diagnosis of some inflammatory lesions, various soft tissue tumors, hepatocellular carcinoma, and lung cancer lesions [34][35][36], there have been only a few reports on extrarenal classical (III)-DMSA uptake [6,37]. It has been proposed that DMSA could penetrate through a damaged cell membrane into the cytoplasm and bind to proteins in the cytoplasm and mitochondria.…”
Section: Discussionmentioning
confidence: 99%
“…The exact mechanism of the extrarenal uptake is unclear with regard to pathology. Although a pentavalent (V)-DMSA scan is useful in the scintigraphic diagnosis of some inflammatory lesions, various soft tissue tumors, hepatocellular carcinoma, and lung cancer lesions [34][35][36], there have been only a few reports on extrarenal classical (III)-DMSA uptake [6,37]. It has been proposed that DMSA could penetrate through a damaged cell membrane into the cytoplasm and bind to proteins in the cytoplasm and mitochondria.…”
Section: Discussionmentioning
confidence: 99%
“…The suggested mechanisms of uptake by inflammatory lesions is either the infiltration into the interstitial space caused by increased capillary permeability or its similar behavior to phosphate ion since it seems to accumulate in areas where calcification is present [22,23] . Its role in the evaluation of intestinal inflammation has been already reported [13,14] , moreover when compared to Tc-99m HMPAO labeled leukocytes, it seems to provide a useful, non-invasive, practical, easy to prepare and accurate alternative method for the assessment of disease activity in patients with IBD [15] . Based on the simultaneous presence of inflammatory response to tissue ischemia, we assumed that Tc-99m (V) DMSA could localize successfully the ischemic bowel and assist in the detection and diagnosis of IC.…”
Section: Discussionmentioning
confidence: 99%
“…A few reports of the scintigraphic findings using radionuclide labelled leukocytes have been published [9][10][11][12] . Moreover, recently pentavalent Tc-99m dimercaptosuccinic acid [Tc-99m (V) DMSA] has been successfully used in the identification of intestinal inflammation [13][14][15] . To our knowledge, its role in the diagnosis of intestinal ischemia has not been yet reported in the literature.…”
Section: Introductionmentioning
confidence: 99%
“…The visualisation of joint involvement by Leucoscan in patients with Crohn's disease suggests that it may be of use for this purpose only. On the other hand, based on the data of Lee et al [2] and our own unpublished data, 99m Tc-(V) DMSA can be suggested as a reliable tracer that could substitute for 99m Tc-WBC scintigraphy in IBD patients.…”
Section: Dear Sirmentioning
confidence: 91%
“…We performed 99m Tc-Leucoscan scintigraphy in seven patients with clinically active Crohn's disease [Crohn's disease activity index (CDAI) >150]. Three of these patients subsequently underwent technetium 99m (V) dimercaptosuccinic acid (DMSA) scintigraphy, which has recently been suggested to be a useful diagnostic test for the detection and localisation of intestinal inflammation [2]. All patients had a definitive diagnosis of Crohn's disease confirmed by radiological, endoscopic and histological studies.…”
Section: Dear Sirmentioning
confidence: 99%