Use of surface modified natural zeolite (SMNZ) in pharmaceutical preparations Part 1. Mineralogical and technological characterization of some industrial zeolite-rich rocks

Cappelletti, Piergiulio; Colella, Abner; Langella, Alessio; Mercurio, Mariano; Catalanotti, Lilia; Monetti, Vincenzo; Gennaro, Bruno de

doi:10.1016/j.micromeso.2015.05.048

Cited by 41 publications

(25 citation statements)

References 44 publications

(50 reference statements)

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“…This type of morphology, together with the high Si/Al ratio typical of these natural zeolites, leaves many free surfaces available to interact with large surfactant molecules, which, however, cannot access the most internal cationic sites of the zeolitic framework, but are able to micellize on the surface of the same tuffs. The obtained results are confirmed by previous experiments in which a clinoptilolite-rich sample coming from New Mexico was also used [31,42]. Lastly, through the HPLC analysis of the liquid phase, no release of HDTMA by SMNZs was found, at least under the conditions in which the AEC evaluation was performed.…”

Section: (%) Phi (%)supporting

confidence: 83%

“…In brief, samples were investigated by qualitative X-Ray Powder Diffraction (XRPD), using a PANalytical X'Pert Pro diffractometer equipped with a RTMS detector (X'Celerator), under the following operating conditions: CuKα radiation, 40 kV, 40 mA, scanning range from 3 to 80 • 2Θ, equivalent step size 0.0179 • 2Θ, equivalent counting time 120 s per step. Quantitative mineralogical characterization was carried out using the RIR/Rietveld method with internal standard, by means of TOPAS 4.2 software (BRUKER AXS Company) [42].…”

Section: Mineralogical Characterizationmentioning

confidence: 99%

“…The chemical composition of the two tuffs was evaluated by digesting, under microwave-induced heating (Perkin Elmer Multiwave 3000 oven), a weighed amount of sample in a mixed HCl and HNO 3 and HF solution. After the addition of H 3 BO 3 to attain fluoride complexation, the resulting solution was analyzed by ICP atomic emission spectrophotometry, using a Perkin Elmer Optima 2100 DV apparatus [42]. Loss on ignition (L.O.I.)…”

Section: Mineralogical Characterizationmentioning

confidence: 99%

“…The ECEC evaluation was performed only with HDTMA-Br since previous experience [42] demonstrated, in the evaluation of the ECEC of clinoptilolite, phillipsite and chabazite samples that the influence of the selected surfactant (HDTMA-Br, HDTMA-Cl, CP-Cl and BC-Cl) on the results was negligible.…”

Section: Ion-exchange Characterizationmentioning

confidence: 99%

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Zeolite-Rich Composite Materials for Environmental Remediation: Arsenic Removal from Water

et al. 2020

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Natural zeolites are used as adsorbents in purification processes due to their cation-exchange ability and molecular sieve properties. Surface modified natural zeolites (SMNZs), produced by attaching cationic organic surfactants to the external surface, can simultaneously act as ionic exchangers and organic molecule adsorbents. In this paper, SMNZs were produced and investigated as adsorbents for As(V) removal from wastewater: two natural zeolites, clinoptilolite and phillipsite, were modified using HDTMA-Br and HDTMA-Cl as surfactants. The obtained samples were then characterized under static and dynamic conditions. Results showed that As(V) removal follows a pseudo-second order kinetic, with fast adsorption rates: every sample reached 100 % removal in 2 h, while equilibrium data showed a Langmuir-like behavior, with a greater anion uptake by the HDTMA-Br modified SMNZs due to the formation of a compact and complete micellar structure. Finally, fixed-bed tests were performed to characterize the samples under dynamic conditions assessing the effect of severe operating parameters on the dynamic exchange capacity, selectivity and efficiency of the process. The obtained results demonstrate a good ability of the tested materials to adsorb As(V) from wastewater, confirming the effectiveness of the proposed surface modification technique in expanding the possibility of using natural zeolites in these processes.

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Section: (%) Phi (%)supporting

confidence: 83%

Section: Mineralogical Characterizationmentioning

confidence: 99%

Section: Mineralogical Characterizationmentioning

confidence: 99%

Section: Ion-exchange Characterizationmentioning

confidence: 99%

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Zeolite-Rich Composite Materials for Environmental Remediation: Arsenic Removal from Water

et al. 2020

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“…Moreover, developmental studies by Tan et al [18] and Dey et al [19] on the kaolinite functionality as pharmaceutical carrier reported that the drug loading capacities and controlled release by this clay mineral can be improved by means of physical and chemical modifications, as well as by hybridation with biopolymers [20][21][22]. In additions, some important natural and modified microporous aluminosilicate minerals (e.g., zeolite and phillipsite) have been proved excellent functionalities in the drug loading and controlled release as pharmaceutical carrier and hence they are compatible with kaolin minerals for solid dosage formulations [23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients

et al. 2019

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The present work aimed at assessing the pharmaceutical tableting properties of some Egyptian kaolin samples belong to the Abu Zenima kaolin deposits (estimated at 120 million tons). Four representative samples were selected based on kaolinite richness and their structural order-disorder degree, and after purification, they were dried at 70 • C and heated from room temperature up to 400 • C (10 • C/min). Mineralogy, micromorphology, microtexture, granulometry, porosimetry, moisture content, bulk and tapped density, direct and indirect flowability, and tableting characteristics are studied. Results indicated that purified kaolin samples were made up of 95-99% kaolinite, <3% illite, 1% quartz and 1% anatase. The powder showed mesoporous character (pore diameters from 2 to 38 nm and total pore volume from 0.064 to 0.136 cm 3 /g) with dominance of fine nanosized particles (<1 µm-10 nm). The powder flow characteristics of both the ordered (Hinckley Index HI > 0.7, crystallite size D001 > 30 nm) and disordered (HI < 0.7, D001 < 30 nm) kaolinite-rich samples have been improved (Hausner ratio between 1.24 and 1.09) as their densities were influenced by thermal treatment (with some observed changes in the kaolinite XRD reflection profiles) and by moisture content (variable between 2.98% and 5.82%). The obtained tablets exhibited hardness between 33 and 44 N only from the dehydrated powders at 400 • C, with elastic recovery (ER) between 21.74% and 25.61%, ejection stress (ES) between 7.85 and 11.45 MPa and tensile fracture stress (TFS) between 1.85 and 2.32 MPa, which are strongly correlated with crystallinity (HI) and flowability (HR) parameters. These findings on quality indicators showed the promising pharmaceutical tabletability of the studied Egyptian kaolin powders and the optimization factors for their manufacturability and compactability.

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Building Stones and Technological Materials of the Campi Flegrei Caldera, Italy

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Use of surface modified natural zeolite (SMNZ) in pharmaceutical preparations Part 1. Mineralogical and technological characterization of some industrial zeolite-rich rocks

Cited by 41 publications

References 44 publications

Zeolite-Rich Composite Materials for Environmental Remediation: Arsenic Removal from Water

Zeolite-Rich Composite Materials for Environmental Remediation: Arsenic Removal from Water

Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients

Building Stones and Technological Materials of the Campi Flegrei Caldera, Italy

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