Use of Surgical Laser for Excision of a Neurofibroma Associated With Neurofibromatosis Type-1

Abstract

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that affects approximately 1/3500 individuals. Various bone manifestations and peripheral nerves neoplastic lesions associated with NF1 are seen in the jaws. Several oral manifestations may occur in this disorder; therefore the dentist's knowledge and multidisciplinary management of these patients are extremely important. Case Presentation: In the present article, we present the use of a high-power surgical laser to excise a neurofibroma in a patient with several intraoral manifestations associated with NF1. Conclusion: The use of diode laser (808 nm) for excision biopsy of tongue nodules showed no thermal damage to the tissue, allowing an adequate histopathological analysis of the neurofibroma

Rare nonsyndromic recurrent solitary gingival neurofibroma in an older adult

“…Management of neurofibromas has traditionally involved simple scalpel excision, and more recently incisional biopsy followed by laser ablation or excisional laser biopsy. 12 Other recommendations have included removal of the underlying periosteum and inclusion of a 5 mm surgical margin. 11,13 For suspected gingival neurofibromas, clinicians should carefully balance the decision to achieve an overly conservative excision, risking formation of a mucogingival defect and potential need for gingival grafting, versus the incorporation of somewhat wider tissue margins to lessen the chance of lesional recurrence.…”

“…Management of neurofibromas has traditionally involved simple scalpel excision, and more recently incisional biopsy followed by laser ablation or excisional laser biopsy 12 . Other recommendations have included removal of the underlying periosteum and inclusion of a 5 mm surgical margin 11,13 .…”

Type I Neurofibromatosis: Case Report and Review of the Literature Focused on Oral and Cutaneous Lesions

“…Moreover, NF1 patients present a higher lifetime cancer risk (59.6%) in contrast to the general population (30.8%) [ 22 ]. Malignant peripheral nerve sheath tumor (MPNST) is the main malignancy which develops in 5% to 13% of NF1 patients [ 4 , 18 , 22 ], with poor prognosis [ 23 ]. Intra-cranial malignancies such as gliomas, ependymoma, and childhood astrocytomas are also well known [ 12 , 23 ].…”

“…Intra-osseus jaw bone lesions related to NF1 are also reported and consist mostly of the widening of the mandibular canal which may be associated with an irregular border of the canal and enlarged mandibular foramina unrelated to any tumor mass [ 3 , 4 , 7 , 9 , 16 , 18 ]. Intra-osseus neurofibromas resulting in well-defined radiolucent lesions have also been reported [ 7 , 9 ].…”

Uso do laser de baixa intensidade como tratamento da sensibilidade pós-clareamento dentário: Uma revisão de literatura

“…Os lasers de Alta Intensidade também podem ser utilizados em diversas especialidades nas áreas da odontologia, como: gengivoplastias, frenectomias, procedimentos de laser curetagem, hiperplasias, ulotomias, remoções de lesões da mucosa oral, fibromas, mucoceles, grânulos de fordyce, ulectomias, na área da dentistica atua na realização de preparos cavitários, tratamentos para inibir a desmineralização do esmalte dentário, remoção de tecidos cariados, descontaminação de superfícies dentárias, condicionamento interno de cerâmicas, tratamento de má formações vasculares. Santanna et al, 2017;Amaral et al, 2018).…”