Use of sympathomimetic amines to correct premenstrual urticaria and anaphylaxis

Check, Jerome H.

doi:10.12891/ceog4727.2019

Cited by 3 publications

(6 citation statements)

References 19 publications

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“…One hundred twelve articles were found to include a case report meeting our inclusion criteria 3–114 . Within these articles, 132 unique cases of AIPD were identified.…”

Section: Resultsmentioning

confidence: 99%

“…Others include the following: dapsone (2), 15,95 inhaled corticosteroids, 90 tacrolimus, 109 dextroamphetamine sulfate (2), 98 and omalizumab 61 AIPD, autoimmune progesterone dermatitis; GnRH, gonadotropin releasing hormone; OCPs, oral contraceptive pills.…”

Section: Resultsmentioning

confidence: 99%

“…Others include the following: dapsone (2), 15,95 inhaled corticosteroids, 90 tacrolimus, 109 dextroamphetamine sulfate (2), 98 and omalizumab 61 …”

Section: Resultsmentioning

confidence: 99%

“…These included the following: immunoglobulin E (IgE) levels ( 6), 12,61,89,99,100,106 biopsy (4), 15,26,45,56 progesterone antibody test (2), 35,38 ELISpot assay, 42 in vitro interferon-γ release test, 31 lymphocyte transformation challenge, 91 oral progesterone challenge, 22 vaginal progesterone challenge, 51 progesterone pessary challenge, 58 mast cell testing, 6 progesterone add-back challenge, 67 salivary enzyme immunoassay, 17 and water load test. 98…”

Section: Diagnosismentioning

confidence: 99%

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Autoimmune Progesterone Dermatitis: A Systematic Review

et al. 2021

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Autoimmune progesterone dermatitis (AIPD) is a cyclical, cutaneous reaction to endogenous progesterone that occurs throughout the menstrual cycle. The cutaneous manifestations of AIPD vary greatly from patient to patient, ranging anywhere from urticaria to erythema multiforme to anaphylaxis. As such, recognition, diagnosis, and management of this condition are difficult for clinicians. In the present article, we conducted a systematic review of 112 articles and 132 individual cases to summarize the clinical features and presentation of AIPD while also summarizing the successes and failures of different treatment plans. Despite the great variety in clinical presentations, it is clear from the data that ovulation-suppressing medical therapies and surgery have the greatest success in treating AIPD, whereas more commonly used therapies such as antihistamines and systemic corticosteroids frequently fail in providing any relief. Further research is necessary to determine the exact pathogenesis of AIPD and allow for more targeted treatment.

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“…One hundred twelve articles were found to include a case report meeting our inclusion criteria 3–114 . Within these articles, 132 unique cases of AIPD were identified.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Others include the following: dapsone (2), 15,95 inhaled corticosteroids, 90 tacrolimus, 109 dextroamphetamine sulfate (2), 98 and omalizumab 61 …”

Section: Resultsmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Autoimmune Progesterone Dermatitis: A Systematic Review

et al. 2021

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“…There have been several reports of dopaminergic effi cacy for insidious headaches [57,58]. Other times there may be a suspected etiology e.g., keratoconus, intra-cranial hypertension (pseudotumor cerebri) temporomandibular joint syndrome, or concussions [59][60][61][62].…”

Section: Dopaminergic Drugs To Treat Medical Conditions That Are More...mentioning

confidence: 99%

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

H Check*

2024

J Biomed Res Environ Sci

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Based on a conglomeration of basic science research studies a model of hypothetical mechanisms of how the fetal semi-allograft can develop into a live baby was created. One of the tenets of the model is that it is necessary to remodel some of the typically thick-walled uterine arteries found during the proliferative phase into thin-walled spiral arteries to allow nutrient exchange between mother and fetus through an autoimmune mechanism during the luteal phase. The model suggests that the rise in progesterone inhibits dopamine. One function of dopamine is to diminish cellular permeability allowing irritants to infuse into the endometrium thus evoking an inflammatory reaction. The body must suppress these cellular immune cells from attacking the fetus. Progesterone activates membrane progesterone receptors which produces immunomodulatory proteins e.g., the Progesterone Induced Blocking Factor (PIBF), which negates the killing effect of cellular immunity. One hypothesis suggested that PIBF may be secreted by malignant tumors facilitating these tumors with foreign antigens to escape immunosurveillance and thus metastasize. Progesterone receptor antagonists e.g., mifepristone, which suppresses PIBF, have successfully increased length and quality of life in patients with a large variety of end stage treatment resistant cancers. Excessive permeability of various tissues was hypothesized to be related to possible relative deficiency of dopamine. A large variety of medical conditions have been ameliorated significantly by the use of dopaminergic drugs e.g. dextroamphetamine or cabergoline. The model explains why certain conditions may get worse premenstrually e.g., pelvic pain or headaches by the added suppressive effect of progesterone on dopamine. Though possibly further research may modify this model, based on the present hypothesis, a large number of treatment refractory conditions had very successful improvement based on treating with drug releasing dopamine thus correcting tissue permeability disorders.

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