Use of Synthetic Peptides as Immunogens for Developing a Vaccine Against Human Chorionic Gonadotropin

This paper reviews how immunomodulation through active vaccination has evolved in the past 25 years. Although initially it progressed isolated from the main stream of immunological research and vaccine development, lately it merged with this main stream and is taking full advantage of the newest developments in vaccinology. The first immunomodulation vaccine is already on the market, while various others are close to it. Not in the least because one of the major stumbling blocks of immunomodulation through active vaccination, the inherent low immunogenicity of 'self' antigens, has in a number of other cases been solved. Most progress has been made in veterinary applications and has helped to formulate practical rules, necessary to break immunotolerance. It is not unlikely that these rules will be used to design better immunomodulation vaccines to be used in humans; notably to control fertility or combat tumours.

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Immunogenicity of a fusion protein linking the beta subunit carboxyl terminal peptide (CTP) of human chorionic gonadotropin to the B subunit of Escherichia coli heat-labile enterotoxin (LTB)

Rock

Reich

Lyu

et al. 1996

Vaccine

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Use of Synthetic Peptides as Immunogens for Developing a Vaccine Against Human Chorionic Gonadotropin

Cited by 3 publications

References 25 publications

The use of maleimidocaproyloxysuccinimide to prepare malarial peptide carrier immunogens immunogenicity of the linking region

The use of maleimidocaproyloxysuccinimide to prepare malarial peptide carrier immunogens immunogenicity of the linking region

Basic aspects of immunomodulation through active immunization

Immunogenicity of a fusion protein linking the beta subunit carboxyl terminal peptide (CTP) of human chorionic gonadotropin to the B subunit of Escherichia coli heat-labile enterotoxin (LTB)

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