Use of the bovine pericardial patch and fibrin sealant in meningomyelocele closure

Gürer, Bora; Kertmen, Hayri; Aktürk, Umut Doğu; Kalan, Mehmet; Şekerci, Zeki

doi:10.1007/s00701-014-2099-4

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…Autologous and heterologous pericardium has been used in human medicine for a number of different applications, including cardiovascular procedures, [14][15][16] abdominal herniorrhaphy, 17 cholangioplasty, 18 meningomyelocoele closure, 19 treatment for corneal perforation 20 or tracheal reconstruction. 21 In veterinary medicine, pericardium has previously been used in cardiovascular surgery, [22][23][24][25][26] oesophageal patching, diaphragmatic herniorrhaphy 27 and closure of large defects.…”

Section: Discussionmentioning

confidence: 99%

Pericardial flap to repair a pulmonary laceration in a cat with pyothorax

López¹,

Martinoli²

2018

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 2-year-old female neutered domestic shorthair cat was presented for investigation of acute onset tachypnoea and dyspnoea. Pyothorax was diagnosed based on thoracic radiographs and fluid analysis. Medical treatment consisted of bilateral thoracostomy tube placement, antibiotic therapy and thoracic lavage. After 12 days of medical management infection was still present, warranting exploratory thoracotomy. At surgery, encapsulated abscesses were found in the left lung, right cranial and right middle lobes. The right caudal lobe was the only macroscopically non-abscessated lobe, and appeared to have a parenchymal laceration 8 mm long over the dorsolateral surface. Following partial pericardiectomy, mediastinectomy and debridement of abscesses, a pericardial flap was reflected caudolaterally and apposed over the laceration to seal the affected lung lobe. This flap was sutured to a rim of fibrinous adhesion that was partially covering this lobe. After 8 days the cat was discharged with antibiotic therapy for 3 more weeks. Follow-up assessment at 19 and 38 weeks postoperatively confirmed the cat to have good exercise tolerance. Thoracic radiographs at 19 weeks revealed good bilateral aeration of the pulmonary parenchyma without pleural effusion.Relevance and novel informationLung lobe laceration can be treated by lung lobectomy or direct suturing of the lung parenchyma. This is the first report using a pericardial flap to repair a lung laceration. Pericardial flap was successfully used to treat this lung laceration where lobectomy was contraindicated. Encouraging results were present at 8 months postoperatively.

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Section: Discussionmentioning

confidence: 99%

Pericardial flap to repair a pulmonary laceration in a cat with pyothorax

López¹,

Martinoli²

2018

Journal of Feline Medicine and Surgery Open Reports

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“…It was demonstrated that, for instance, in meningomyelocele repair, which is the most common and complex birth defect of the central nervous system, consecutive separate closures of the neural placode, dura mater, lumbar fascia, subcutaneous layer, and skin need to be conducted. The use of a fibrin-enriched bovine pericardial patch at the fascial level—between the dural sac and the skin—provided sufficient soft tissue coverage in meningomyelocele repair surgery [ 122 ].…”

Section: Fibrin and Skin Reconstructionmentioning

confidence: 99%

Advances in Fibrin-Based Materials in Wound Repair: A Review

Bayer

2022

Molecules

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The first bioprocess that occurs in response to wounding is the deterrence of local hemorrhage. This is accomplished by platelet aggregation and initiation of the hemostasis cascade. The resulting blood clot immediately enables the cessation of bleeding and then functions as a provisional matrix for wound healing, which begins a few days after injury. Here, fibrinogen and fibrin fibers are the key players, because they literally serve as scaffolds for tissue regeneration and promote the migration of cells, as well as the ingrowth of tissues. Fibrin is also an important modulator of healing and a host defense system against microbes that effectively maintains incoming leukocytes and acts as reservoir for growth factors. This review presents recent advances in the understanding and applications of fibrin and fibrin-fiber-incorporated biomedical materials applied to wound healing and subsequent tissue repair. It also discusses how fibrin-based materials function through several wound healing stages including physical barrier formation, the entrapment of bacteria, drug and cell delivery, and eventual degradation. Pure fibrin is not mechanically strong and stable enough to act as a singular wound repair material. To alleviate this problem, this paper will demonstrate recent advances in the modification of fibrin with next-generation materials exhibiting enhanced stability and medical efficacy, along with a detailed look at the mechanical properties of fibrin and fibrin-laden materials. Specifically, fibrin-based nanocomposites and their role in wound repair, sustained drug release, cell delivery to wound sites, skin reconstruction, and biomedical applications of drug-loaded fibrin-based materials will be demonstrated and discussed.

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