Use of the frontal assessment battery in evaluating executive dysfunction in patients with Huntington’s disease

Rodrigues, Guilherme; Souza, Carolina Pinto; Cetlin, Roberto Satler; Oliveira, Daniel Sabino de; Pena-Pereira, Márcio Alexandre; Ujikawa, L.; Marques, Wilson; Tumas, Vítor

doi:10.1007/s00415-009-5197-0

Cited by 38 publications

(36 citation statements)

References 34 publications

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“…Second, the capability of the FAB to detect executive dysfunctions in various diseases affecting fronto-striatal circuits constitutes a recent issue. Specifically, the FAB has been effectually used to document the presence of executive dysfunctions in various neurological diseases (e.g., amyotrophic lateral sclerosis [27,28]; Huntington’s disease [29]; multiple system atrophy and progressive supranuclear palsy [30]; Parkinson’s disease [31-34]) and psychiatric disorders (e.g., addictive substance abuse [35,36]; depression in Parkinson’s disease [37,38]). The results of the current study add to this rapidly-growing body of knowledge by strengthening the claim that various indices of FAB performance can be considered as valid assessments of lateral prefrontal, notably anterior insular, functioning.…”

Section: Discussionmentioning

confidence: 99%

Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients

et al. 2013

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BackgroundThe Frontal Assessment Battery (FAB) is a brief battery of six neuropsychological tasks designed to assess frontal lobe function at bedside [Neurology 55:1621-1626, 2000]. The six FAB tasks explore cognitive and behavioral domains that are thought to be under the control of the frontal lobes, most notably conceptualization and abstract reasoning, lexical verbal fluency and mental flexibility, motor programming and executive control of action, self-regulation and resistance to interference, inhibitory control, and environmental autonomy.MethodsWe examined the sensitivity of performance on the FAB to frontal lobe damage in right-hemisphere-damaged first-ever stroke patients based on voxel-based lesion-behavior mapping.ResultsVoxel-based lesion-behavior mapping of FAB performance revealed that the integrity of the right anterior insula (BA13) is crucial for the FAB global composite score, for the FAB conceptualization score, as well as for the FAB inhibitory control score. Furthermore, the FAB conceptualization and mental flexibility scores were sensitive to damage of the right middle frontal gyrus (MFG; BA9). Finally, the FAB inhibitory control score was sensitive to damage of the right inferior frontal gyrus (IFG; BA44/45).ConclusionsThese findings indicate that several FAB scores (including composite and item scores) provide valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the MFG and in the IFG.

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Section: Discussionmentioning

confidence: 99%

Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients

et al. 2013

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“…8,12 One study of 20 mild-to-moderate HD patients found significantly lower scores on the MoCA total score and almost all cognitive domains, compared to normal controls. 8 Another study of 41 HD patients found that the total HD sample scored significantly lower than normal controls on the MMSE; however, performance in each stage of the disease was not compared to normal controls.…”

Section: Discussionmentioning

confidence: 99%

“…8 Another study of 41 HD patients found that the total HD sample scored significantly lower than normal controls on the MMSE; however, performance in each stage of the disease was not compared to normal controls. 12 …”

Section: Discussionmentioning

confidence: 99%

Usefulness of the Montreal Cognitive Assessment (MoCA) in Huntington's disease

et al. 2013

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The Montreal Cognitive Assessment (MoCA) is a brief screening instrument for dementia that is sensitive to executive dysfunction. This study examined its usefulness for assessing cognitive performance in mild, moderate, and severe Huntington’s disease (HD), as compared to the MMSE. We compared MoCA and MMSE total scores and the number of correct answers in five cognitive-specific domains in 104 manifest HD patients and 100 matched controls. For the total HD sample, and for the moderate and severe patients, significant differences between both MoCA and MMSE total scores and almost all cognitive-specific domains emerged. Even mild HD subjects showed significant differences with regard to total score and several cognitive domains on both instruments. We conclude that the MoCA, although not necessarily superior to the MMSE, is a useful instrument for assessing cognitive performance over a broad level of functioning in HD.

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“…8 Forty of the 574 identified cohort studies met the inclusion criteria (Table II). We were able to include 19 studies in the statistical analysis [44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62]. They involved a total of 1939 (44.3% women, n = 14 studies) patients with a mean age of 48.9 AE 2.3 years (n = 13) and a mean baseline TFC score of 10.1 AE 0.7 (n = 11).…”

Section: R E S U L T Smentioning

confidence: 99%

The most appropriate primary outcomes to design clinical trials on Huntington's disease: meta‐analyses of cohort studies and randomized placebo‐controlled trials

Salem

Saleh

Youssov

et al. 2014

Fundamemntal Clinical Pharma

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Huntington's disease (HD) is a rare multifactorial neurodegenerative disease. Both its natural course and any placebo effect are poorly known. All are obstacles to design randomized controlled trials (RCTs). We conducted meta-analyses of RCTs and cohorts on all parameters of the Unified Huntington's Disease Rating Scale to determine the most appropriate outcomes and to minimize the number of patients required to design RCTs in HD. Twenty-four RCTs were included, involving 838 patients with a mean age of 50.0 ± 2.3 years and a mean total functional capacity (TFC) score of 9.8 ± 0.6. Nineteen cohorts were included involving 1939 patients with a mean age of 48.9 ± 2.3 years and a mean TFC of 10.1 ± 0.7. Significant deterioration was observed in RCTs for all scores except behavioral score. Effect sizes were comparable between RCTs and cohorts for each test except that there was a significant difference for TFC. The weighted mean deterioration per year on the TFC scale was -0.5 (0.2) in RCTs and -0.8 (0.2) in cohorts. The lowest number of patients required per group in a RCT was for TFC (19 per group), whereas 30 patients would be required per group for the total motor score (TMS). For cognition, the verbal fluency test required the smallest number of patients: 104 per group. In conclusion, TMS and TFC are the most appropriate outcomes to design RCTs on HD likewise the verbal fluency test for cognition. Our results suggest an effect of placebo administration on the total functional capacity.

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Use of the frontal assessment battery in evaluating executive dysfunction in patients with Huntington’s disease

Cited by 38 publications

References 34 publications

Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients

Performance on the Frontal Assessment Battery is sensitive to frontal lobe damage in stroke patients

Usefulness of the Montreal Cognitive Assessment (MoCA) in Huntington's disease

The most appropriate primary outcomes to design clinical trials on Huntington's disease: meta‐analyses of cohort studies and randomized placebo‐controlled trials

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