Use of the Hypospray® in Dermatology

Development of jet injection and its application to intralesional therapy in dermatology.

“…has considered the use of a jet injector in dermatological therapy. Apart from the work of Krantz (1960), the only other studies of jet therapy in dermatology had been those of Larrick and Thompson (1949) and Preston et al (1951). These reports described principally the use of procaine for local anaesthesia and the treatment of lichen simplex chronicus with the Hypospray.…”

Jet-Induced Tissue Disruption for Blood Release

“…Previous post-mortem tissue studies conducted with jet injectors have shown that high-speed fluid jets tend to follow the path of least resistance into tissue and generally do not penetrate the walls of blood vessels [9]- [11]. One study reported a haemorrhage from a jet injection into a fingertip, but observed no disruption of moderate-sized vessels [12]. Capillaries are the smallest and thinnest blood vessels and exert the smallest surface wall tension (0.016 N/m), leading to little resistance against deformation [13].…”

New Way to Deliver Fluids: Endoscopic Jet Injection Into the Beagle Prostate

“…In contrast to regular subdermal injection as introduced by Wood in 1853, jet injection uses the fact that fluid, which is pressed through small openings at high pressure, can penetrate tissue as a so-called jet. Applications are therapy for diabetes mellitus, 2 vaccination, 3 dermatological therapies 4 and local anesthesia, 5 especially in dental medicine. 6 Conventional needle injection into the prostate has been used diagnostically for lymphography, scintigraphic imaging of prostatic lymph nodes and immunoscintigraphy.…”