Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2

Коротаева, Т. В.; Зоткин, Е. Г.; Несмеянова, О. Б.; Везикова, Н. Н.; Ершова, О. Б.; Измозжерова, Н. В.; Петрова, М. С.; Кастанян, А. А.; Якупова, С. П.; Agaf'ina, Alina S.; Stanislav, Marina; Новодережкина, Е. А.; Насонов, Е. Л.; Mease, Philip J

doi:10.14412/1995-4484-2017-151-158

Cited by 5 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Для лечения ПсА применяют нестероидные противовоспалительные препараты (НПВП), внутрисуставное введение глюкокортикоидов (ГК), синтетические базисные противовоспалительные препараты (сБПВП), таргетные сБПВП, а также генно-инженерные биологические препараты (ГИБП) -ингибиторы ФНОα, ингибиторы ИЛ12/23 и ИЛ17 [53][54][55].…”

unclassified

“…Применение ингибитора ИЛ12/23 устекинумаба также оказалось эффективным для лечения псориаза и ПсА, в меньшей степени продемонстрировано влияние на спондилит [59]. В последние годы широко используются моноклональные антитела к ИЛ17 (секукинумаб) [25,54,60]. Большинство пациентов с ПсА демонстрируют хороший ответ на терапию ГИБП уже через 3-6 мес от начала лечения, однако у части из них эффект может отсутствовать или быть недостаточным, что требует коррекции терапии.…”

unclassified

See 1 more Smart Citation

Psoriatic arthritis: pathogenetic features and innovative therapies

Лила¹,

Насонов

Коротаева³

2019

Naučno-praktičeskaâ revmatologiâ

Self Cite

View full text Add to dashboard Cite

The paper considers the modern concepts of the etiology and pathogenesis of psoriatic arthritis (PsA). The latter is currently indicated as a T-cell-mediated disease that is based on the activation of cellular immunity, followed by the hyperproduction and imbalance of key pro- and anti-inflammatory cytokines, such as tumor necrosis factor-α (TNF- α), interleukin-1β (IL-1β), IL-6, IL-12/23, and IL-17. The paper presents the basic principles of diagnosis and clinical manifestations of the disease and notes the importance of screening questionnaires, the use of which allows specialists to diagnose PsA early, by actively identifying articular complaints, the characteristic clinical and radiological signs of damage to the joint, spine, and entheses. It is pointed out that the key target of pharmacotherapy for PsA is to achieve remission or minimal activity of the main clinical manifestations of the disease, to slow down or prevent its radiographic progression, to increase the length and quality of life in patients, and to reduce the risk of comorbidities. The authors characterize the major groups of used drugs: nonsteroidal anti-inflammatory drugs, conventional and targeted synthetic disease-modifying antirheumatic drugs, and biological drugs (inhibitors of TNF-α, IL-12/23, and IL-17). The key Treat-to-target principles of patient management are considered; it is noted that strict control over disease activity and treatment results provides suppression of all major clinical manifestations of PsA. The paper also shows the basic principles of the creation and further development of the All-Russian Registry of PsA patients, which makes it possible to optimize management decision-making on the provision of high-tech medical care and drugs for this cohort of patients.

show abstract

unclassified

Psoriatic arthritis: pathogenetic features and innovative therapies

Лила¹,

Насонов

Коротаева³

2019

Naučno-praktičeskaâ revmatologiâ

Self Cite

View full text Add to dashboard Cite

show abstract

Guselkumab in Biologic-Naïve Patients with Active Psoriatic Arthritis in Russia: A Post Hoc Analysis of the DISCOVER-1 and -2 Randomized Clinical Trials

Mease,

Korotaeva,

Shesternya

et al. 2024

Rheumatol Ther

View full text Add to dashboard Cite

Introduction There are limited data on the use of advanced therapies to treat psoriatic arthritis (PsA) in Russia. Guselkumab, an interleukin (IL)-23p19-subunit inhibitor, demonstrated efficacy in patients with PsA in the phase 3 DISCOVER-1 and -2, and COSMOS trials. This analysis evaluated the efficacy and safety of guselkumab in patients with PsA in Russia. Methods This post hoc analysis of DISCOVER-1 and -2 included 1002 biologic-naïve patients with active PsA from Russia ( n = 317) and the rest of the world (RoW; n = 685). Patients received guselkumab 100 mg every 4 weeks (Q4W), or at week 0 and 4 then Q8W, or placebo then guselkumab Q4W at week 24 (Russian: n = 119, 88, and 110, respectively; RoW: n = 216, 246, and 223, respectively). Outcomes through week 52 were pooled (DISCOVER-1 and -2); outcomes from week 52 to 100 represent DISCOVER-2 only. Results In patients from Russia, ≥ 20% improvement in the American College of Rheumatology (ACR20) criteria response rates were higher with guselkumab vs. placebo at week 24, increased through week 52, and were consistent across all guselkumab-treated groups at week 100. Similar trends were generally observed for ACR50, ≥ 90% improvement in Psoriasis Area and Severity Index (PASI90), achievement of Disease Activity in Psoriatic Arthritis (DAPSA) low disease activity/remission and minimal disease activity, enthesitis and dactylitis resolution, ≥ 0.35 improvement in Health Assessment Questionnaire–Disability Index (HAQ-DI) score, improvement in patient-reported pain, and measures in patients with axial PsA (including Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], Ankylosing Spondylitis Disease Activity Score [ASDAS], and patient-reported spinal pain). Efficacy responses were similar between patients from Russia and the RoW across all endpoints and timepoints. The safety profile of guselkumab in patients from Russia was consistent with previous findings. Conclusion This analysis demonstrated that the safety and efficacy profiles of guselkumab across all PsA domains and patient-reported outcomes in patients from Russia were similar to those in patients from the RoW. Trial Registration Numbers NCT03162796 and NCT03158285. Supplementary Information The online version contains supplementary material available at 10.1007/s40744-024-00713-x.

show abstract

Results of studying the clinical efficacy and safety of tofacitinib in the treatment of psoriatic arthritis

Коротаева¹,

Логинова²

2019

Sovremennaâ revmatologiâ

Self Cite

View full text Add to dashboard Cite

The paper reviews of the data available in the literature on the clinical efficacy and safety of tofacitinib (TOFA) in the treatment of psoriatic arthritis (PsA). It considers the mechanism of action of TOFA, which is mainly in the selective inhibition of signal transmission due to its effect on the activity of JAK3 and/or JAK1, the enzymes that ensure the function of turning on and turning off the signals transmitted by cytokines. TOFA is noted to directly or indirectly act on a wide range of a number of molecules that play an important role in the pathogenesis of PsA.The paper analyzes the current data on the clinical efficacy of TOFA in treating PsA, which have been obtained in the 12-month OPAL Broaden study including patients with PsA and an inadequate response to synthetic disease-modifying anti-rheumatic drugs and in the 6-month OPAL Beyond study enrolling those with PsA and an inadequate response to tumor necrosis factor-α (TNF-α) inhibitors. It is noted that the results of these studies confirmed the efficacy of the drug in treating PsA not only according to the data of objective (medical) monitoring, but also to the subjective characteristics of pain, to the global assessment of disease activity, fatigue, as well as the mental and physical components of the SF-36 quality of life questionnaire.It is concluded that the current findings allow JAK inhibitors to be recommended as a new pathogenetically sound approach to treating PsA and suggest that TOFA has benefits in managing patients unresponsive to therapy with TNF-α inhibitors.

show abstract

Use of the interleukin-17A inhibitor secukinumab in psoriatic arthritis: a subanalysis of the Russian population in the international randomized clinical trials FUTURE 1 and FUTURE 2

Cited by 5 publications

References 25 publications

Psoriatic arthritis: pathogenetic features and innovative therapies

Psoriatic arthritis: pathogenetic features and innovative therapies

Guselkumab in Biologic-Naïve Patients with Active Psoriatic Arthritis in Russia: A Post Hoc Analysis of the DISCOVER-1 and -2 Randomized Clinical Trials

Results of studying the clinical efficacy and safety of tofacitinib in the treatment of psoriatic arthritis

Contact Info

Product

Resources

About