Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes

Chang, Eun Mi; Han, Ji Eun; Kim, You Shin; Lyu, Sang Woo; Lee, Woo Sik; Yoon, Tae Ki

doi:10.1007/s10815-010-9530-4

Cited by 91 publications

(70 citation statements)

References 16 publications

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“…In two studies, no LPS was administered in the tNC arm [35,38]; there was a statistically significant difference in clinical pregnancy rate favoring tNC against AC without suppression (OR 1.63, 95 % CI 1.24-2.14; two studies). Luteal phase support was given in five studies [36,[40][41][42][43]; the ORs for clinical pregnancy and live birth rates were not significantly different (OR 1.32 (95 % CI 0.90-1.93; four studies) and 1.47 (95 % CI 0.72-3.03; two studies), respectively).…”

Section: Tnc Versus Ac Without Suppressionmentioning

confidence: 97%

“…A total of five studies, two RCTs [33,34] and three retrospective cohort studies [35][36][37], making a total of 2081 embryo transfer (ET) cycles, were included.…”

Section: Tnc Versus Mncmentioning

confidence: 99%

“…However, LPS was administered to both tNC and mNC arms in another two studies [34,35]. In the study by Tomas et al [36], no LPS was given to the mNC group whereas LPS in the form of vaginal progesterone gel or micronized progesterone tablet was administered to the tNC group.…”

Section: Tnc Versus Mncmentioning

confidence: 99%

“…A total of eight studies, all being retrospective cohort studies [35,36,[38][39][40][41][42][43], making a total of 8762 ET cycles, were included.…”

Section: Tnc Versus Ac Without Suppressionmentioning

confidence: 99%

“…4). A total of six studies, one RCT [50] and five retrospective cohort studies [32,35,36,51,52] making a total of 6074 ET cycles, were included.…”

Section: Tnc Versus Ac With Suppressionmentioning

confidence: 99%

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Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Yaralı́

Polat

Mümüşoğlu

et al. 2016

J Assist Reprod Genet

109

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Purpose The purpose of this study was to evaluate the best protocol to prepare endometrium for frozen embryo replacement (FER) cycles. Methods This study is a systematic review and meta-analysis. Following PubMed and OvidSP search, a total of 1166 studies published after 1990 were identified following removal of duplicates. Following exclusion of studies not matching our inclusion criteria, a total of 33 studies were analyzed. Primary outcome measure was live birth. The following protocols, including true natural cycle (tNC), modified natural cycle (mNC), artificial cycle (AC) with or without suppression, and mild ovarian stimulation (OS) with gonadotropin (Gn) or aromatase inhibitor (AI), were compared. Results No statistically significant difference for both clinical pregnancy and live birth was noted between tNC and mNC groups. When tNC and AC without suppression groups are compared, there was a statistically significant difference in clinical pregnancy rate in favor of tNC, whereas it failed to reach statistical significance for live birth. When tNC and AC with suppression groups are compared, there was a statistically significant difference in live birth rate favoring the latter. Similar pregnancy outcome was noted among mNC versus AC with or without suppression groups. Similarly, no difference in clinical pregnancy and live birth was noted when ACs with or without suppression groups are compared. Conclusions There is no consistent superiority of any endometrial preparation for FER. However, mNC has several advantages (being patient-friendly; yielding at least equivalent or better pregnancy rates when compared with tNC and AC with or without suppression; may not require LPS). Mild OS with Gn or AI may be promising.

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Section: Tnc Versus Ac Without Suppressionmentioning

confidence: 97%

“…A total of five studies, two RCTs [33,34] and three retrospective cohort studies [35][36][37], making a total of 2081 embryo transfer (ET) cycles, were included.…”

Section: Tnc Versus Mncmentioning

confidence: 99%

Section: Tnc Versus Mncmentioning

confidence: 99%

“…A total of eight studies, all being retrospective cohort studies [35,36,[38][39][40][41][42][43], making a total of 8762 ET cycles, were included.…”

Section: Tnc Versus Ac Without Suppressionmentioning

confidence: 99%

“…4). A total of six studies, one RCT [50] and five retrospective cohort studies [32,35,36,51,52] making a total of 6074 ET cycles, were included.…”

Section: Tnc Versus Ac With Suppressionmentioning

confidence: 99%

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