“…Secondary ABG with iliac crest bone is standard in many comprehensive cleft care protocols (Paterson et al, 2016), despite the fact that donor site pain remains a significant limitation (Rawashdeh, 2008; Meara et al, 2011; Myeroff and Archdeacon, 2011). Attempts to more effectively manage donor site pain have often been met with disappointing results (Wilkes and Thomas, 1994; Hahn et al, 1996; Morrison and Jacobs, 2003; Blumenthal et al, 2005; Singh et al, 2005; Morgan et al, 2006; Baig et al, 2006; Singh et al, 2007; Charous, 2008; Coulthard et al, 2008; Elder et al, 2008; Ouaki et al, 2009; Yoost et al, 2009; Sbitany et al, 2010; Sbitany et al, 2010; Meara et al, 2011; Visoiu, 2014; Muzaffar et al, 2016). Furthermore, alternatives to autologous bone have been explored to alleviate donor site morbidity, such as allograft and Bone Morphogentic Protein-2 (BMP-2) (Francis et al, 2013; Sivak et al, 2014).…”