Chronic rhinosinusitis (CRS), a very common and sometimes debilitating disease, has been shown to have a major impact on overall quality of life. The association between anxiety, depression, and sinonasal symptom scores has previously been evaluated, and a significant correlation has been identified in several studies. However, it remains unclear which comes first. Is it depression and anxiety that cause symptoms, or is it CRS and its attendant functional issues, including sleep disturbance, that result in anxiety and depression? Tomoum et al.