Use of the plasma triglyceride/high-density lipoprotein cholesterol ratio to identify cardiovascular disease in hypertensive subjects

Salazar, Martín R.; Carbajal, Horacio A; Espeche, Walter G; Aizpurúa, Marcelo; Sisnieguez, Carlos Enrique Leiva; Sisnieguez, Betty C Leiva; March, Carlos; Stavile, Rodolfo N.; Balbín, Eduardo; Reaven, Gerald M.

doi:10.1016/j.jash.2014.08.002

Cited by 32 publications

(41 citation statements)

References 22 publications

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“…We next assessed if the L/A ratio at different time points in pregnancy could predict CV risk at 5 years follow-up based on TG/HDL-C ratio, apoB/apoA ratio and LDL/HDL-C ratio. ROC analysis (Additional file 1: Table S1) demonstrated that adiponectin, leptin and the L/A ratio significantly predicted enhanced CV risk based on established cut-offs [9, 21, 22] for the ratios of TG/HDL-C ratio, apoB/apoA ratio and LDL/HDL-C ratio at 5 years follow-up. The L/A ratio showed the highest AUCs for all lipid ratios, but the association with the TG/HDL-C ratio was particularly strong at all time-points (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Levels of apolipoprotein A (apoA), apoB, HDL-C, low density lipoprotein cholesterol (LDL-C) (direct measurements), and triglycerides (TG) were measured from frozen serum samples at follow-up at the clinical chemistry laboratory at Oslo University Hospital Rikshospitalet. The ratios of TG/HDL-C, LDL/HDL-C and apoB/apoA are known risk factors for CVD [9, 21, 22], and were calculated based on the above measurement. For leptin and adiponectin analysis, we used fasting plasma from venous EDTA blood sampled on ice, centrifuged for 25 min at 3000 g at 4 °C, separated, and stored at −80 °C until analyzed.…”

Section: Methodsmentioning

confidence: 99%

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Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus

Lekva

Michelsen

Aukrust

et al. 2017

Cardiovasc Diabetol

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BackgroundGestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction may be a key event in promoting CVD. The aim of the study was to examine the relationships between GDM, cardiovascular risk, and plasma adiponectin, leptin and the leptin/adiponectin (L/A) ratio in pregnancy and at 5 years after the index pregnancy.MethodsThis population-based prospective cohort included 300 women who had an oral glucose tolerance test (OGTT) during pregnancy. Five years later, the OGTT was repeated along with dual-energy X-ray absorptiometry, lipid analysis, and pulse wave velocity analysis. Fasting adiponectin and leptin levels were measured four times during pregnancy and at follow-up.ResultsWe found the L/A ratio higher in GDM women both during pregnancy and follow-up compared to non-GDM women. A high L/A ratio during pregnancy was associated with CV risk based on lipid ratios at follow-up, especially the TG/HDL-C ratio. Further, interaction analysis indicated that an increase in the L/A ratio of 1 unit was associated with a higher CV risk in GDM compared to normal pregnancy. Finally, low adiponectin levels independently predicted increased lipid ratios at follow-up.ConclusionsTaken together, our findings suggest that high L/A ratio in pregnancy and in particularly in those with GDM are associated with an unfavorable CVD risk profile during follow-up. Future studies should investigate if a dysregulated leptin and adiponectin profile during pregnancy is associated with atherosclerotic disease during long-term follow-up.Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-016-0492-4) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus

Lekva

Michelsen

Aukrust

et al. 2017

Cardiovasc Diabetol

View full text Add to dashboard Cite

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“…A study by Onat and colleagues demonstrated that atherogenic index of plasma as determined by “log10 triglyceride/high‐density lipoprotein cholesterol” predicted diabetes and high blood pressure after adjustments for covariates. In a recent investigation, Salazar and colleagues investigated the prognostic impact of TG/HDL ratio with regard to cardiovascular disease in hypertensive patients. The study included 947 patients divided into normotensive (n=574) and hypertensive (n=373) groups .…”

Section: Discussionmentioning

confidence: 99%

“…In a recent investigation, Salazar and colleagues investigated the prognostic impact of TG/HDL ratio with regard to cardiovascular disease in hypertensive patients. The study included 947 patients divided into normotensive (n=574) and hypertensive (n=373) groups . In this study, the authors demonstrated two novel issues.…”

Section: Discussionmentioning

confidence: 99%

The Role of Plasma Triglyceride/High‐Density Lipoprotein Cholesterol Ratio to Predict New Cardiovascular Events in Essential Hypertensive Patients

Turak

Afsar

Özcan

et al. 2015

J of Clinical Hypertension

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4Triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) has been suggested as a simple method to identify unfavorable cardiovascular outcomes in the general population. The effect of the TG/HDL-C ratio on essential hypertensive patients is unclear. About 900 consecutive essential hypertensive patients (mean age 52.9AE12.6 years, 54.2% male) who visited our outpatient hypertension clinic were analyzed. Participants were divided into quartiles based on baseline TG/HDL-C ratio and medical records were obtained periodically for the occurrence of fatal events and composite major adverse cardiovascular events (MACEs) including transient ischemic attack, stroke, aortic dissection, acute coronary syndrome, and death. Participants were followed for a median of 40 months (interquartile range, 35-44 months). Overall, a higher quartile of TG/HDL-C ratio at baseline was significantly linked with higher incidence of fatal and nonfatal cardiovascular events. Using multivariate Cox regression analysis, plasma TG/HDL-C ratio was independently associated with increased risk of fatal events (hazard ratio [HR], 1.25; 95% confidence interval [CI], 1.13-1.37; P≤.001] and MACEs (HR, 1.13; 95% CI, 1.06-1.21; P≤.001). Increased plasma TG/HDL-C ratio was associated with more fatal events and MACEs in essential hypertensive patients.

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“…The relationship between high TG/HDL-C and CVD risk has also been studied in patients with specific comorbidities, such as obesity with or without type 2 diabetes9 10 and hypertension,11 but all in primarily Caucasian populations. To identify high-risk patients, various cut-offs and classifications of TG/HDL-C have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Association of triglyceride to HDL cholesterol ratio with cardiometabolic outcomes

Yang

Rigdon

Tsai

2019

Journal of Investigative Medicine

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Electronic medical records (EMRs) offer a potential opportunity to identify patients at high risk for cardiometabolic disease, which encompasses type 2 diabetes and cardiovascular disease (CVD). The objective of this retrospective cohort study is to use information gathered from EMR to investigate the association between triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) and cardiometabolic outcomes in a general population of subjects over 50 years of age during a follow-up period of 8–9 years. TG/HDL-C was recorded for each of 1428 subjects in 2008, and diagnoses of type 2 diabetes and CVD were recorded through chart review until 2017. Cox proportional hazards models controlling for demographic characteristics and other risk factors demonstrated that high TG/HDL-C (>2.5 in women or >3.5 in men) was significantly associated with increased incidence of type 2 diabetes (HR 1.66; 95% CI 1.07 to 2.57; p=0.0230). There was also a suggested association between high TG/HDL-C and incidence of CVD (HR 1.51; 95% CI 0.98 to 2.35; p=0.0628). These findings suggest that using TG/HDL-C, which can be easily calculated from data in an EMR, should be another tool used in identifying patients at high cardiometabolic risk.

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Use of the plasma triglyceride/high-density lipoprotein cholesterol ratio to identify cardiovascular disease in hypertensive subjects

Cited by 32 publications

References 22 publications

Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus

Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus

The Role of Plasma Triglyceride/High‐Density Lipoprotein Cholesterol Ratio to Predict New Cardiovascular Events in Essential Hypertensive Patients

Association of triglyceride to HDL cholesterol ratio with cardiometabolic outcomes

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