Use of the Quinolones in Skin and Skin Structure (Osteomyelitis) and Other Infections

Karchmer, Adolf W.

doi:10.1016/b978-012059517-4/50014-3

Cited by 4 publications

(5 citation statements)

References 70 publications

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“…1 Concentrations in bone are usually 20-50% of peak serum concentrations. 20 Concentrations in cerebrospinal fluid are lower than serum concentrations; percentage of serum concentration achieved in inflamed meninges is 14-26% for ciprofloxacin, 61% for levofloxacin, and 50-80% for moxifloxacin. 19 In patients with markedly reduced or absent renal function, half-life is increased about 2-fold for ciprofloxacin and 4.5-fold for ofloxacin, levofloxacin, and gatifloxacin, and is unchanged for moxifloxacin.…”

Section: Patterns Of Quinolone Resistance In the United States Frommentioning

confidence: 99%

“…In complicated SSSI (infected pressure ulcers, diabetic foot infections), gram-negative enteric bacilli and anaerobes become significant. 20 Ofloxacin is indicated only for management of uncomplicated SSSI. Due to the importance of gram-negative aerobes and anaerobes in complicated SSSI, ciprofloxacin and levofloxacin are indicated in these infections.…”

Section: Skin and Skin Structure Infectionsmentioning

confidence: 99%

“…In adults, acute osteomyelitis and septic arthritis are usually caused by S. aureus, coagulase-negative staphylococci, and gramnegative aerobes. 20 In osteomyelitis due to extension from a contiguous focus (diabetic foot, infected pressure ulcers), infection is frequently polymicrobial, with S. aureus, coagulase-negative staphylococci, enterococci, gram-negative aerobes, and anaerobes being major pathogens. Acute osteomyelitis occasionally develops into chronic osteomyelitis, with a similar spectrum of pathogens.…”

Section: Bone and Joint Infectionsmentioning

confidence: 99%

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Integrating Fluoroquinolones into the Hospital Formulary

Bertino

2001

Pharmacotherapy

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With the increasing availability of new agents, selection of fluoroquinolones for formulary inclusion can be difficult. Appropriate evaluation of the important characteristics (pharmacokinetic and pharmacodynamic properties, antimicrobial activity, efficacy, tolerability, cost) of these agents should allow selection of the most cost-effective ones. Evidence from in vitro studies and clinical trials indicates differences exist among fluoroquinolones, especially in terms of activity against gram-positive, aerobic organisms. For selected clinical situations, it may be important to choose an agent that is available in both intravenous and oral formulations. Comparative drug costs, as well as costs associated with potential clinical failure and adverse events, should be evaluated carefully. Dosage regimens should be considered, as shorter durations of therapy and less frequent dose administration may lead to reduced labor costs and increased patient compliance, thereby improving effectiveness and economic efficiency.

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Section: Patterns Of Quinolone Resistance In the United States Frommentioning

confidence: 99%

Section: Skin and Skin Structure Infectionsmentioning

confidence: 99%

Section: Bone and Joint Infectionsmentioning

confidence: 99%

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Integrating Fluoroquinolones into the Hospital Formulary

Bertino

2001

Pharmacotherapy

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“…The quinolones have also been effective in treating sexually transmitted diseases, such as gonococcal and chlamydial, chancroid, and pelvic infections. Some quinolones have also been useful in treating immunocompromised patients with febrile neutropenia [17][18][19][20][21][22][23]. Not all fluoroquinolones have been approved for use in the treatment of all of the aforementioned infections.…”

Section: Modifications To the Quinolone Nucleusmentioning

confidence: 99%

The fluoroquinolones as antibacterial compounds; an overview on biological and chemical activities aspects.

Asif¹

2016

JCPR

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Fluoroquinolones are the most promising anti-infective chemotherapy agents depicting broad spectrum and potent activity. Various substituted fluoroquinolones derivatives were evaluated against gram negative, gram positive and resistance bacteria strains. These drugs are having DNA gyrase and growth inhibition activity. They have a relatively simple molecular nucleus, which is willing to many structural modifications. These agents have several favorable properties such as good bioavailability, tissue penetrability and relatively low incidence of adverse and toxic effects. They are effective in treatment of various infectious diseases. This paper is an attempt to the therapeutic prospects of fluoroquinolones as antibacterial agents.

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“… 74 Moxifloxacin is approved for the treatment of acute bacterial sinusitis, simple skin and skin structure infections, chronic bronchitis, and community-acquired pneumonia. 75 Gemifloxacin is approved for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate-severe community-acquired pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Quinolone Antibiotics: Resistance and Therapy

Tang¹,

Zhao²

2023

IDR

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The clinical application of quinolone antibiotics is particularly extensive. In addition to their high efficiency in infectious diseases, the treatment process brings multiple hidden dangers or side effects. In this regard, drug resistance becomes a major challenge and is almost unavoidable in the clinical application of quinolones. Both genetic and phenotypic variations contribute to bacterial survival resistance under antibiotic therapy. This review is focusing on the drug discovery history, compound structure, and bactericidal mechanism of quinolone antibiotics. Recent studies bring a more in-depth insight into the research progress of quinolone antibiotics in the causes of death, drug resistance formation, and closely related SOS response after disease treatment at this stage. Combined with the latest clinical studies, we summarize the clinical application of quinolone antibiotics and further lay a theoretical foundation for the mechanism study of resistant or sensitive bacteria in response to quinolone treatment.

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Use of the Quinolones in Skin and Skin Structure (Osteomyelitis) and Other Infections

Cited by 4 publications

References 70 publications

Integrating Fluoroquinolones into the Hospital Formulary

Integrating Fluoroquinolones into the Hospital Formulary

The fluoroquinolones as antibacterial compounds; an overview on biological and chemical activities aspects.

Quinolone Antibiotics: Resistance and Therapy

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