Use of the single subject design for practice based primary care research

Janosky, Janine E.

doi:10.1136/pgmj.2004.031005

Cited by 47 publications

(23 citation statements)

References 20 publications

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“…This iterative design has proven to be effective in practice-based research, used since 1945 in drug testing, internal medicine, cardiology, and nutrition (Francis 2005, Newcombe 2005). Single subject design has proven effectiveness when research questions are driven by clinical work with crucial questions, such as adherence to OAs (Janosky 2005). This design supports refining the ADHERE intervention prior to testing, with limited research funds.…”

Section: Methodology and Designmentioning

confidence: 86%

A trial examining an advanced practice nurse intervention to promote medication adherence and symptom management in adult cancer patients prescribed oral anti‐cancer agents: study protocol

Spoelstra

Burhenn

DeKoekkoek

et al. 2015

Journal of Advanced Nursing

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AimTo report a study protocol that refines then examines feasibility, preliminary efficacy, and satisfaction of ADHERE, an intervention using motivational interviewing and brief cognitive behavioral therapy as a mechanism for goal-oriented systematic patient education to promote symptom management and adherence among cancer patients prescribed oral anti-cancer agents. Background Cancer treatment with oral anti-cancer agents shifts responsibility for managing treatment from clinicians in supervised cancer centers to patients and their caregivers. Thus, a need exists to standardize start-of-care for support patient self-management of care at home. Design A two-phase quasi-experimental sequential design with repeated measures. Methods Sixty five adult patients newly prescribed an oral anti-cancer agent will be recruited from three community cancer centers. Phase one will enroll 5 patients to refine the ADHERE intervention prior to testing, using an iterative process. After completion, Phase two will enroll 30 patients who receive usual care to examine symptoms and ahderence. Advanced practice nurses will then be trained. Then 30 patients will be enrolled in the intervention group and provided ADHERE, a 4-week intervention using semi-structured interactions (initial face-to-face session and once a week phone sessions over 3-weeks) and a Toolkit to promote selfmanagement of care. Outcome measures include: oral anti-cancer agents adherence rate, symptom presence and severity, feasibility, and satisfaction with ADHERE. This protocol was approved January 2014 and is registered at ClinicalTrials.gov (Identifier NCT02337296). Discussion This nurse-led intervention has the potential to standardize the start-of-care trainingfor the patients to self-manage when prescribed oral anti-cancer agents for treatment. Summary Statement Why this study is needed? No standard of care exists for patients newly prescribed oral anti-cancer agents.  Many cancer patients treated with oral anti-cancer agents have difficulty managing symptoms, which may lead to adverse events and difficulty adhering to the medication regimen.  Sub-optimal adherence rates for cancer patients prescribed oral anti-cancer agents exist, which may impact cancer treatment effectiveness.

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Section: Methodology and Designmentioning

confidence: 86%

A trial examining an advanced practice nurse intervention to promote medication adherence and symptom management in adult cancer patients prescribed oral anti‐cancer agents: study protocol

Spoelstra

Burhenn

DeKoekkoek

et al. 2015

Journal of Advanced Nursing

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“…Because the number of participants is expected to be low, and because of the very variable nature of brain injury, a randomised controlled trial design is not considered appropriate [1]. Instead, a single-subject research design (SSRD, or "n=1" design) [8] is to be employed. In this design, time series data is collected for each participant as they experience different activities or treatments.…”

Section: Research Goals and Methodsmentioning

confidence: 99%

Multi-player online video games for cognitive rehabilitation

Colman

2013

CHI '13 Extended Abstracts on Human Factors in Computing Systems

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“…This type of research design is known as the single case experimental design, which is both well-suited for busy primary care clinicians and within the purview of doctor of nursing practice (DNP)-prepared NPs. 51 There are several supportive strategies that NPs can offer adults who present with acute bronchitis, which might lead to increased satisfaction and decreased inappropriate antibiotic prescribing. A recent study of 655 adults regarding their behaviors and expectations related to acute respiratory infections found that although most of these individuals expected a prescription for antibiotics and/or a prescription for their symptoms, they also desired Summary of diagnostic and treatment recommendations for adults with acute cough illness *1,2,10,11,13,18,20-27,30,34-38,41-48,52…”

Section: Wwwtnpjcommentioning

confidence: 99%