Use of the Water-Soluble Contrast Medium Gastrografin in Treatment of Adhesive Small Bowel Obstruction in Patients with and Without Chronic Radiation Enteropathy: A Single-Center Retrospective Study

Gu, Lili; Zhu, Feng; Xie, Tingbin; Feng, Dan; Gong, Jianfeng; Li, Ning

doi:10.12659/msm.930046

Cited by 3 publications

(4 citation statements)

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“…A recent retrospective study reported that patients with ASBO who underwent NGT-G treatment had initial surgery and re-operation rates of 41.4% and 11.2%. 6 Although their patient background and study design differed from the current study, our treatment strategy achieved much better 1-year surgery rates. This may be due to the careful observation and switching to LT even when colonic contrast was observed at 24 h. ASBO recurrence frequently occurs due to the inability of non-surgical treatment to resolve itself.…”

Section: Discussionmentioning

confidence: 61%

“…2 The present study found no significant differences in 1-year recurrence rates between both groups. The most recent latest retrospective study reported a recurrence rate of 41.9% during 1-year follow-up, 6 whereas another recent retrospective study found a 21.3% overall recurrence risk following non-surgical management (during a median follow-up interval of 3.6 years). 9 In line with this, the current study observed a recurrence rate of around 30%, which was within the range of previously published findings.…”

Section: Discussionmentioning

confidence: 97%

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Long‐term outcomes of nasogastric tube with Gastrografin for adhesive small bowel obstruction

Nishie

Shimura

Katano

et al. 2021

J of Gastro and Hepatol

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Background:We had previously reported that the administration of Gastrografin through a nasogastric tube (NGT-G) followed by long tube (LT) strategy could be a novel standard treatment for adhesive small bowel obstruction (ASBO); however, the long-term outcomes after initial improvement remain unknown. This study aimed to analyze the long-term outcomes of first-line NGT-G. Methods: Enrolled patients with ASBO were randomly assigned to receive LT or NGT-G between July 2016 and November 2018. Thereafter, the cumulative surgery rate, cumulative recurrence rate, and overall survival (OS) rate were analyzed. In addition, subset analysis was conducted to determine the cumulative recurrence rate according to colonic contrast with Gastrografin at 24 h. Results: A total of 223 patients (LT group, n = 111; NGT-G group, n = 112) were analyzed over a median follow-up duration of 550 days. The cumulative 1-year surgery rates, cumulative 1-year recurrence rates, and 1-year OS rates in the LT and NGT-G groups were 18.8% and 18.1%, 30.0% and 31.7%, and 99.1% and 96.6%, respectively; no significant differences were observed between both groups. In the NGT-G group, a negative colonic contrast at 24 h demonstrated a higher tendency for future recurrence compared with a positive colonic contrast at 24 h (1-year recurrence rate: negative contrast, 46.9% vs positive contrast, 27.6%). Conclusions: Gastrografin through a nasogastric tube followed by LT can be a promising treatment strategy for ASBO, with long-term efficacies equivalent to initial LT placement.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 97%

Long‐term outcomes of nasogastric tube with Gastrografin for adhesive small bowel obstruction

Nishie

Shimura

Katano

et al. 2021

J of Gastro and Hepatol

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“…The studies span an 11‐year period from 2010 to 2021. The studies included 54 retrospective cohort studies [17–70], eight prospective cohort studies [4, 71–77], seven RCTs [78–84], and four retrospective case–control studies [85–88]. 45 studies were single centre, 20 utilised databases and 8 were multicentre.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of participant descriptors reported in studies of adhesive small bowel obstruction

Rashid,

Kumar,

Lee

2024

Colorectal Disease

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AimReporting of participant descriptors in studies of adhesive small bowel obstruction (ASBO) can help identify characteristics associated with favourable outcomes and allow comparison with other studies and real‐world clinical populations. The aim was to identify the pattern of participant descriptors reported in studies assessing interventions for ASBO.MethodThis systematic review was registered with PROSPERO (CRD42021281031) and reported in line with the PRISMA checklist. Systematic searches of Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were undertaken to identify studies assessing operative and non‐operative interventions for adults with ASBO. Studies were dual screened for inclusion. Descriptors were categorised into conceptual domains by the research team.ResultsSearches identified 2648 studies, of which 73 were included. A total of 156 unique descriptors were identified. On average, studies reported 12 descriptors. The most frequently reported descriptors were sex, age, SBO aetiology, history of abdominal surgery, BMI and ASA classification. The highest number of descriptors in a single study was 34, compared to the lowest number of descriptors which was one. Pathway factors were the least frequently described domain. Overall, 37 descriptors were reported in just one study.ConclusionThere is a lack of consistency in participant descriptors reported in studies of SBO. Furthermore, a significant proportion of the descriptors were used infrequently. This makes it challenging to assess whether study participants are representative of the wider population. Further work is required to develop a Core Descriptor Set to standardise the reporting of patient characteristics and reduce heterogeneity between studies.

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“…The only probable explanation found is because of its high osmolality, it allows the shifting of fluid into the bowel lumen, decreasing edema and diluting bowel content for easy passage. As described above, it also aids in the need's evaluation for surgery in bowel obstruction [11]. Our study aims to evaluate the diagnostic and therapeutic value of gastrografin in adhesive intestinal obstruction.…”

Section: Introductionmentioning

confidence: 96%

Role of Gastrografin in Adhesive Intestinal Obstruction

Kumar

Naz

Mangi

et al. 2021

JPRI

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Objective: To determine the role of gastrografin in adhesive intestinal obstruction. Study Design: This is an observational study. Setting: Study carried out at General Surgery Department, Liaquat University of Medical and Health Sciences Jamshoro and Shaheed Benazir Bhutto Medical College, Lyari Karachi, from January 2020 to July 2021. Material & Method: Patients having clinical and radiological signs evidence of adhesive bowel obstruction over the age of 18 years were selected for the study. One hundred milliliters of gastrografin were given via nasogastric tube and its transit was followed by serial abdominal radiographs and fluoroscopy. Results: In the time of 1 and half years, we received 53 patients with adhesive intestinal obstruction. It included 54.7% (n= 29) males and 45.2% (n=24) females with a mean age of 61 years. Out of 53 patients, 46 patients had a single previous abdominal surgery. After complete examination and investigations emergency laparotomy was performed in 15% (n=8) patients. Hence, out of total 53 patients, 27 patients fit into our criteria for gastrografin meal and follow through. Fluoroscopy revealed a partial obstruction in 19 patients and complete obstruction in 8 patients. After gastrografin follow through obstruction was relieved in 17 patients within the meantime of 63 hours (range 20-78h). Conclusion: In our study, gastrografin is found to be of great diagnostic and therapeutic value, with fewer adverse effects. It also reduces the need for surgery, hence decreasing the financial burden of operative treatment. In Pakistan, its use is still limited because of a lack of equipment, expertise, and radiological imaging facilit.

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Use of the Water-Soluble Contrast Medium Gastrografin in Treatment of Adhesive Small Bowel Obstruction in Patients with and Without Chronic Radiation Enteropathy: A Single-Center Retrospective Study

Cited by 3 publications

References 31 publications

Long‐term outcomes of nasogastric tube with Gastrografin for adhesive small bowel obstruction

Long‐term outcomes of nasogastric tube with Gastrografin for adhesive small bowel obstruction

A systematic review of participant descriptors reported in studies of adhesive small bowel obstruction

Role of Gastrografin in Adhesive Intestinal Obstruction

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