2021
DOI: 10.1007/s40618-021-01555-y
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Use of thyroid hormones in hypothyroid and euthyroid patients: A 2020 THESIS questionnaire survey of members of the Danish Endocrine Society

Abstract: Purpose The standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients. Methods An e-mail with an invitation to participate in an online survey investigating practices about substitution with thyroid hormones was sent to all members of the Danish Endocrine Society (DES). Res… Show more

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Cited by 28 publications
(88 citation statements)
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“…In accordance with current guidelines, LT4 remains the treatment of choice for hypothyroidism in Poland. This was in agreement with other national THESIS investigations in Bulgaria, Denmark and Italy [22][23][24]. However, some important deviations from evidence-based practice concerning indications for treatment with thyroid hormones were noted.…”
Section: Clinical Indications For Treatment With Thyroid Hormonessupporting
confidence: 91%
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“…In accordance with current guidelines, LT4 remains the treatment of choice for hypothyroidism in Poland. This was in agreement with other national THESIS investigations in Bulgaria, Denmark and Italy [22][23][24]. However, some important deviations from evidence-based practice concerning indications for treatment with thyroid hormones were noted.…”
Section: Clinical Indications For Treatment With Thyroid Hormonessupporting
confidence: 91%
“…Respondents had little opportunity to use alternative LT4 formulations in their clinical practice, because of national market limitations, in opposition to Danish physicians, where i.e. liquid LT4 is a widely available treatment option [24]. An oral solution has been commercially available since the last quarter of 2020 and it is more expensive than LT4 tablets.…”
Section: Choice Of Lt4 Formulationmentioning
confidence: 99%
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“…Physicians from North America were found to be more likely to prescribe T4+T3 combination than physicians from outside North America (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.2 to 2.9). A questionnaire survey called Treatment of Hypothyroidism in Europe by Specialists: an International Survey (THESIS) was done recently among members of national endocrine societies in five European countries [33][34][35][36][37]. Although LT4 remained the drug of choice for initiating treatment of hypothyroidism, 1% to 1.5% of respondents already used combined T4+T3 at the initiation of thyroid hormone therapy.…”
Section: Prevalence Of T4+t3 Combination Therapymentioning
confidence: 99%
“…Endocrinologists from four European countries answered questions in the THESIS survey on what they considered the most likely or unlikely cause of persistent symptoms in LT4-treated patients with a normal TSH [34][35][36][37]. Their answers are listed in Table 6.…”
Section: Pathophysiological Explanations For Persistent Symptoms On Lt4mentioning
confidence: 99%