2011
DOI: 10.4103/0976-500x.81902
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Use of topical brimonidine to prevent intraocular pressure elevations following Nd: YAG-laser posterior capsulotomy

Abstract: Objective:To study the effect of brimonidine on intraocular pressure (IOP) following capsulotomy among Indian subjects.Materials and Methods:The study was a nonrandomized trial with open label.Results:80% of the subjects showed a decrease in IOP after instilling 0.2% brimonidine (1 hour pre capsulotomy). No such decrease was observed in control. After 1 and 4 h post capsulotomy a statistically significant decrease in IOP ranging between 1–10 mmHg was found in 73.3% of the treatment group.Conclusions:In the pre… Show more

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Cited by 10 publications
(15 citation statements)
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“…As mentioned in the manuscript, that sample size was purposive based on operational feasibility. [ 1 ] We agree with the reader's comment about possible elaboration of the statistical tests applied, but keeping in view the word limits, mandate of the Journal of Pharmacology and Pharmacotherapeutics and the peers who would follow the article as well the journal, it was decided to give more emphasis on content, result and discussion on the use of topical brimonidine to prevent intraocular pressure (IOP) elevations following Nd:YAG-laser posterior capsulotomy. [ 2 ] As rightly mentioned by the reader, ciprofloxacin group acts as the placebo arm in this superiority trial and various other drugs used in glaucoma such as acetazolamide, timolol, pilocarpine and so on have established efficacy for such post laser IOP spikes since many years now.…”
mentioning
confidence: 88%
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“…As mentioned in the manuscript, that sample size was purposive based on operational feasibility. [ 1 ] We agree with the reader's comment about possible elaboration of the statistical tests applied, but keeping in view the word limits, mandate of the Journal of Pharmacology and Pharmacotherapeutics and the peers who would follow the article as well the journal, it was decided to give more emphasis on content, result and discussion on the use of topical brimonidine to prevent intraocular pressure (IOP) elevations following Nd:YAG-laser posterior capsulotomy. [ 2 ] As rightly mentioned by the reader, ciprofloxacin group acts as the placebo arm in this superiority trial and various other drugs used in glaucoma such as acetazolamide, timolol, pilocarpine and so on have established efficacy for such post laser IOP spikes since many years now.…”
mentioning
confidence: 88%
“…As mentioned in the manuscript, that sample size was purposive based on operational feasibility. [ 1 ] We agree with the reader's comment about possible elaboration of the statistical tests applied, but keeping in view the word limits, mandate of the Journal of Pharmacology and Pharmacotherapeutics and the peers who would follow the article as well the journal, it was decided to give more emphasis on content, result and discussion on the use of topical brimonidine to prevent intraocular pressure (IOP) elevations following Nd:YAG-laser posterior capsulotomy. [ 2 ]…”
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confidence: 88%
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“…These mechanisms cause alteration in aqueous drainage and a resultant increase in IOP occurs. 7,8,9 Patients & Methods A Descriptive case series study was being conducted at the Ophthalmology Department, Rawalpindi Medical University. The study was completed within 6 months from 21.02.15 to 21.08.15.…”
Section: Introductionmentioning
confidence: 99%
“…[1] The authors have rightly highlighted the need to manage the raised IOP after Nd:YAG-laser posterior capsulotomy. However, I would like to bring to the fore a few observations.…”
mentioning
confidence: 99%