Use of Tregs as a cell‐based therapy via CD39 for benign prostate hyperplasia with inflammation

Jin, Xi; Lin, Tianhai; Yang, Guang; Cai, Huawei; Tang, Bo; Liao, Xinyang; Li, Huifang; Rothenberg, Marc E.; Gong, Ling; Xu, Hang; Sun, Yan; Tan, Ping; Yin, Jianqiong; Ma, Hongwen; Ai, Jianzhong; Wang, Kunjie; Wang, Qiang; Yang, Lu; Li, Hong

doi:10.1111/jcmm.15137

Cited by 8 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…found that NK cells expressing the ectonucleotidases, CD73, produced more IL-10 and TGF-β via STAT3 transcriptional activity ( 37 ). In addition, CD39+ Tregs secreted more IL-10 and TGF-β to inhibit inflammation ( 38 ). These data indicated that CD38+CD39+ NK cells expressed more IL-10 and TGF-β for immune suppression.…”

Section: Discussionmentioning

confidence: 99%

CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation

et al. 2022

View full text Add to dashboard Cite

The ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory properties. However, the roles of CD38 and CD39 expressed NK cells in HIV disease require elucidation. Our study showed that the proportions of CD38+CD39+ NK cells in HIV-infected individuals were positively associated with HIV viral loads and negatively associated with the CD4+ T cell count. Furthermore, CD38+CD39+ NK cells expressed additional inhibitory receptors, TIM-3 and LAG-3, and produced more TGF-β. Moreover, autologous NK cells suppressed the proliferation of CD8+ T and CD4+ T cells of HIV-infected individuals, and inhibiting CD38 and CD39 on NK cells restored CD8+ T and CD4+ T cell proliferation in vitro. In conclusion, these data support a critical role for CD38 and CD39 on NK cells in HIV infection and targeting CD38 and CD39 on NK cells may be a potential therapeutic strategy against HIV infection.

show abstract

Section: Discussionmentioning

confidence: 99%

CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Recently, Davidsson et al have reported increased number of stromal CD4 + Tregs in patients with post-atrophic hyperplasia and prostate cancer (26). Jin et al detected low Treg cell count in peripheral blood taken from BPH patients, but they found high Treg infiltration in prostate tissue with mild or moderate inflammation (13). They also found that Treg cells almost disappeared in severely inflamed prostate tissue, and suggested that this inconsistency was caused by the use of different patient samples (13).…”

Section: Discussionmentioning

confidence: 99%

“…Jin et al detected low Treg cell count in peripheral blood taken from BPH patients, but they found high Treg infiltration in prostate tissue with mild or moderate inflammation (13). They also found that Treg cells almost disappeared in severely inflamed prostate tissue, and suggested that this inconsistency was caused by the use of different patient samples (13). The transcription factor called FOXP3 controls the Treg cell system and is the most specific marker of these cells (27).…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, the hypothesis that BPH is an immune-mediated inflammatory disease with a localized autoimmune condition has become increasingly accepted (10)(11)(12). Jin et al reported that Treg cell count was low in peripheral blood taken from BPH patientsand almost nonexistent in severely inflamed prostate tissue (13). Bai et al determined that in patients with chronic prostatitis / chronic pelvic pain syndrome (CP / CPPS, category III prostatitis), FOXP3 mRNA and transforming growth factor beta 1 (TGF-1) levels were significantly lower, but serum tumor necrosis factor-alpha (TNF-α) levels were higher than in control patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Benign Prostatik Patolojilerde Regülatuvar T Hücrelerinin (Treg) Değerlendirilmesi: Pilot Çalışma

Ateş

Amasyalı

Oryaşin

et al. 2021

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Objective:We aimed to evaluate the number and function of regulatory T (Treg) cells in peripheral blood and prostate tissues of patients with histopathologically diagnosed benign prostate hyperplasia (BPH) and asymptomatic chronic prostatitis.Material and Methods:Blood and histopathological data of 19 patients (BPH=10, ACP=9) that underwent transurethral prostate resection were evaluated. Treg cell count in peripheral blood and prostatic tissue with flowcytometry, Forkhead box P3(FOXP3) expression in prostatic tissue by reverse transcription polymerase chain reaction (PCR), and IL-17 measurement in blood samples with ELISA were performed.Results: Flowcytometric analyses showed that mean CD4+T cell count and mean FOXP3 levels in both peripheral blood (CD4+T, p= 0.752; FOXP3, p= 1.000) and prostate tissue (CD4+T, p= 0.458; FOXP3, p= 0.590) were higher in the BPH group compared to the chronic prostatitis group. However this difference was not statistically significant. Similarly, the mean blood IL-17 levels were also higher in BPH groups, but the difference was not statistically significant (p= 0.870). The PCR analyses showed that mean FOXP3 gene expression in the tissue was higher in the chronic prostate group, but again there was no statistically significant difference between the groups (p= 0.116). Conclusion:Since no statistically significant difference was found between BPH and chronic prostatitis in terms of Treg cell number and function in peripheral blood and prostatic tissue, our study supports the thesis that both these pathologies could be autoimmune inflammatory diseases.

show abstract

“…CD39 + Tregs present stronger stability and function under inflammatory conditions ( 23 ). The role of CD39 on Tregs in limiting tissue injury has been studied in myocardial infarction ( 24 ) and benign prostate hyperplasia ( 25 ). All of these findings suggest a potential role of CD39 + Tregs in acute lung inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

CD39+ Regulatory T Cells Attenuate Lipopolysaccharide-Induced Acute Lung Injury via Autophagy and the ERK/FOS Pathway

Chen

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) is characterized by an uncontrollable cytokine storm, which is associated with high mortality due to lack of effective treatment. Regulatory T cells (Tregs) play an indispensable role in maintaining immune homeostasis and CD39 is considered as a functional cell marker of Tregs. In this study, we aimed to evaluate the effect of CD39+ Tregs on acute lung injury (ALI) and investigate the frequency of CD39+ Tregs in ARDS patients. We found that after lipopolysaccharide (LPS) treatment, CD39−/− mice exhibited more severe inflammation and wild type (WT) mice exhibited a decreased frequency of CD39+ Tregs in the peripheral blood. Furthermore, CD39+ Tregs had a protective effect on LPS-induced inflammation in vitro and the adoptive transfer of CD39+ Tregs had a therapeutic effect on ALI in vivo. We further sought to explore the mechanisms that affect CD39 expression on Tregs. LPS-induced inflammation in the lung impaired the immunosuppressive effect of Tregs via the autophagy-mediated downregulation of CD39. In addition, CD39 induced the expression of itself in Tregs via activating the ERK1/2-FOS pathway. Consistent with this finding, the frequency of CD39+ Tregs was also decreased in the peripheral blood of ARDS patients and was positively correlated with disease severity. Our results suggested that the adoptive transfer of CD39+ Tregs may provide a novel method for the clinical prevention and treatment of ARDS.

show abstract

Use of Tregs as a cell‐based therapy via CD39 for benign prostate hyperplasia with inflammation

Cited by 8 publications

References 34 publications

CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation

CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation

Benign Prostatik Patolojilerde Regülatuvar T Hücrelerinin (Treg) Değerlendirilmesi: Pilot Çalışma

CD39+ Regulatory T Cells Attenuate Lipopolysaccharide-Induced Acute Lung Injury via Autophagy and the ERK/FOS Pathway

Contact Info

Product

Resources

About