Use of tris(dipivalomethanato)praseodymium(III) for the determination of the chirality of simple amines and cyclic 1,2-amino alcohols

NMR Studies of Drugs. Applications of a Chiral Lanthanide Shift Reagent to Methoxamine in Chloroform-d or Acetonitrile-d 3.

“…to induce circular dichroism (CD) for some cyclic (steroidal).lI2-amino alcohols and emphasized the need for bidentate chelation for their CD studies (15). Dillon and Nakanishi actually examined phenylpropanolamine (ervthro norephedrine) with Pr(DPM), in dry nonpolar solvents (CDCl,, CCl,, n-hexane) to induce CD; they recognized this substrate as a bidentate amino alcohol with a potential problem, since the -NH, is much less sterically hindered Table 1 representing the slopes for observed chemical shifts versus molar ratios of 2:1.…”