Use of Viscosupplementation for Knee Osteoarthritis

Divine, Jon G.; Shaffer, Michael D.

doi:10.1249/jsr.0b013e31822ed1b4

Cited by 22 publications

(14 citation statements)

References 20 publications

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“…However, this unique occurrence was probably due to inadequate asepsis during the invasive manoeuvre, easily preventable using a sterile procedure, as suggested by other authors [15]. On the other hand, the most common adverse event associated with viscosupplementation is an inflammatory reaction, or flare, at the injection site characterised by pain and swelling [2,4,5,8,10]. These reactions are typically mild, and often self-limiting [8].…”

Section: Discussionmentioning

confidence: 99%

“…IA HA is currently considered a safe and relatively well-tolerated procedure. Indeed, the most common adverse event described is represented by mild and transient inflammatory reaction or flare at the injection site [9,10]. It should be noted that these events occur more frequently with chemically cross-linked compounds (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…It should be noted that these events occur more frequently with chemically cross-linked compounds (e.g. hylan G-F 20), compared to non-chemically modified products, such as sodium hyaluronate [10]. Moreover, the cross-linked hyaluronan seems to be associated with an increased incidence of pseudo-septic arthritis, also called severe acute inflammatory reaction (SAIR) [11].…”

Section: Introductionmentioning

confidence: 99%

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Safety of Intra-Articular Oxygen-Ozone Therapy Compared to Intra-Articular Sodium Hyaluronate in Knee Osteoarthritis: A Randomized Single Blind Pilot Study

Invernizzi¹,

Stagno²,

Carda³

et al. 2017

Int J Phys Med Rehabil

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Objective: Osteoarthritis (OA) is a chronic degenerative musculoskeletal disease and one of the leading causes of chronic musculoskeletal pain, often affecting the knee. Despite intra-articular (IA) injectable hyaluronan (HA) preparations are widely used in the treatment of this debilitating condition, only a few data about their efficacy have been reported so far. Therefore, the use of HA in OA management is not universally recommend in clinical practice. Oxygen-ozone (O 2 O 3 ) therapy can be employed in several pain-related conditions and diseases. However, both its efficacy and safety for IA therapy in knee OA have never been explored. Here, we evaluated the reliability of knee IA therapy with O 2 O 3 compared to IA HA in chronic knee OA.Methods: A total of 42 consecutive chronic OA patients with radiological diagnosis of knee OA were prospectively enrolled in this single-blind, controlled study. After randomization, all patients underwent IA therapy with O 2 O 3 or HA (q1wk) for 4 weeks, with additional 4 weeks of follow-up. Examination of the adverse events occurred during the whole study was performed. To measure knee function and pain, visual analogue scale (VAS), Oxford knee questionnaire (OKQ), and 12-item short form survey (SF-12) were administered. EuroQol five dimensions questionnaire (EQ-5D) was used to assess patients' quality of life.Results: No significant difference in adverse events occurrence was observed. Knee IA treatment with O 2 O 3 showed shorter reduction of pain compared to IA HA. VAS score decreased in both groups during the treatment period (p<0.001), while OKQ score significantly increased (p<0.001). SF-12 and EQ-5D scores were comparable between the two groups of patients.Conclusions: Despite IA administration of O 2 O 3 and hyaluronan are comparable treatments in knee OA both in terms of safety and quality of life improvement, the latter shows longer times of pain reduction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Safety of Intra-Articular Oxygen-Ozone Therapy Compared to Intra-Articular Sodium Hyaluronate in Knee Osteoarthritis: A Randomized Single Blind Pilot Study

Invernizzi¹,

Stagno²,

Carda³

et al. 2017

Int J Phys Med Rehabil

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“…Although the basic science evidence studies suggest that the use of both low molecular weight hyaluronic acid and high molecular weight hyaluronic acid (HMWHA) have disease modifying effects, comparative clinical studies and metaanalyses tends to favour the efficacy of HMWHA for knee OA. [14][15][16][17][18] HA is occurring naturally as a component of synovial fluid (SF) and cartilage matrix. Synovial cells, fibroblasts and chondrocytes synthesize HA and secrete into the knee joint.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of efficacy of autogenous platelet rich plasma versus visco supplementation in treatment of early osteoarthritis of knee

et al. 2019

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Background: Osteoarthritis is a very common chronic degenerative disease most commonly affecting the knee joints. In present study we compared the efficacy of autogenous platelet rich plasma (PRP) versus visco supplementation in treatment of early osteoarthritis of knees.Methods: 30 patients (56 knees) were registered and divided into two groups. Out of which PRP in 28 knees and visco supplementation in 28 knees injected during. Visual analogue scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores were measured. These scores were measured at first visit, 6 weeks, 12 weeks and at 24 weeks.Results: All registered patients were randomized in two groups. Group I (total 16 patients and 28 knees) for intraarticular PRP injection and group II (total 14 patients and 28 knees) for intraarticular viscosupplement injection. Out of 28 knees of group I; 12 (42.85%) knees belonged to grade II and 16 (57.15%) of grade III. Out of 28 knees of group II; 15 (53.57%) knees of grade II and 13 (46.45%) of grade III. None of the knees belonged to grade I and grade 0. There was significant difference in outcome of two treatment groups (p<0.05) at 24 weeks.Conclusions: Treatment with PRP showed a significantly better clinical outcome compared with viscosupplemention at 24 weeks follow up. Although patients achieved lower WOMAC and VAS scores in PRP group at 6 and 12 weeks follow up that was statistically insignificant. We conclude that long term results of PRP are better than viscosupplementation.

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“…arthroscopic in order to debride superficial cartilage irregularities and induce new cartilage generation by deep subchondral exposure or aiming to correct the joint deformity by corrective osteotomy [1]- [3]. Occasionally visco supplementation therapy is used [4]. When the end stage OA is diagnosed, endoprosthetic arthroplasty is preferred.…”

Section: Introductionmentioning

confidence: 99%

Arthroscopic Debridement with Lavage and Arthroscopic Lavage Only as the Treatment of Symptomatic Osteoarthritic Knee

Karkabi

Rosenberg²

2015

OJCD

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In this prospective follow up study we evaluated and compared the effect of arthroscopic lavage with and without debridement as a treatment of moderately osteoarthritic knees in middle aged and elderly population. The study group comprised of 500 patients (250 patients for each type of treatment, mean age 58 years). The patients were followed six months, three years and six years postoperatively. Following both treatments there was a clear deterioration in function of the knee function over the time, as measured starting at six months follow up until six years postoperatively (p < 0.001). This deterioration was more prominent in patients after treatment by the arthroscopic lavage only. We show that for the patients with high functional demand and expectations for long term rehabilitation and improvement both arthroscopic treatments are not satisfactory in more of 60% of cases.

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Use of Viscosupplementation for Knee Osteoarthritis

Cited by 22 publications

References 20 publications

Safety of Intra-Articular Oxygen-Ozone Therapy Compared to Intra-Articular Sodium Hyaluronate in Knee Osteoarthritis: A Randomized Single Blind Pilot Study

Safety of Intra-Articular Oxygen-Ozone Therapy Compared to Intra-Articular Sodium Hyaluronate in Knee Osteoarthritis: A Randomized Single Blind Pilot Study

Comparative evaluation of efficacy of autogenous platelet rich plasma versus visco supplementation in treatment of early osteoarthritis of knee

Arthroscopic Debridement with Lavage and Arthroscopic Lavage Only as the Treatment of Symptomatic Osteoarthritic Knee

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