Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study

Cáceres, Dante; Hancke, Juan L.; Burgos, Rafael A.; Sandberg, F; Wikman, G.

doi:10.1016/s0944-7113(99)80012-9

Cited by 103 publications

(91 citation statements)

References 19 publications

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“…There was a significant decrease in prevalence and intensity of the symptoms in the uncomplicated common colds, compared to the placebo after the Andrographis paniculata regimen intake. 5,75) The relative risk of catching a cold indicated that the preventive effect could be due to immunostimulatory effects of andrographolide. Moreover, Andrographis paniculata accelerated recuperation of common cold patients with symptoms including nasal discharge, nasal stuffiness, sore throat, earache, cough, fever, headache, and malaise.…”

Section: Respiratory System Benefitsmentioning

confidence: 99%

“…Moreover, Andrographis paniculata accelerated recuperation of common cold patients with symptoms including nasal discharge, nasal stuffiness, sore throat, earache, cough, fever, headache, and malaise. 5,75,76) The mechanism of action of Andrographis paniculata in treatment of URI remains unclear to date. The apparent effectiveness of the plant may be based either on its anti-inflammatory properties or on its immunomodulatory properties.…”

Section: Respiratory System Benefitsmentioning

confidence: 99%

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Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Jarukamjorn

Nemoto

2008

JOURNAL OF HEALTH SCIENCE

201

111

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Nowadays, research on medicinal plants has attracted a lot of attention globally. A number of evidence has been accumulated to demonstrate promising potential of medicinal plants used in various traditional, complementary, and alternative systems. In recent years, a medicinal plant, Andrographis paniculata, and its major active phytochemicals have been extensively studied for several pharmacological activities. To understand the mechanism of action, researches have to be carried out at molecular levels. The present review aims at compiling consequential compendium of pharmacological benefits of health on this plant and its major diterpenoid constituent andrographolide that have been tested in various experimental models using modern scientific methodologies.

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Section: Respiratory System Benefitsmentioning

confidence: 99%

Section: Respiratory System Benefitsmentioning

confidence: 99%

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Jarukamjorn

Nemoto

2008

JOURNAL OF HEALTH SCIENCE

201

111

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“…Despite its wide spread medicinal use, very few comprehensive and validated pharmacokinetic analysis are available in the literature. Besides being used as a single herb, it is also a common constituent of a variety of ayurvedic preparations used in the treatment of chronic malaria, diabetes, hepatic toxicity, common cold and loss of appetite (Cáceres et al, 1999;Chopra et al, 1982;Elango et al, 2011;Kapil et al, 1993;Misra et al, 1992;Rahman et al, 1999;Raina et al, 2013;Roxas & Jurenka, 2007;Zhang & Tan, 2000). Pharmacokinetic studies constitute an important phase in the development of new medicine and also to determine the disposition process (absorption, distribution, metabolism and elimination) for selection of the most appropriate route of administration and dose regimen (Liu et al, 2010;Uys et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic analysis and tissue distribution of andrographolide in rat by a validated LC-MS/MS method

Bera

Ahmed

Sarkar

et al. 2013

Pharmaceutical Biology

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Context: Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is widely used in tribal medicine in India and some other countries for multiple clinical applications. It contains andrographolide (AG) (diterpenoid lactone), a major phytomarker which probably accounts for its medicinal properties.Objective: This study investigates the site-specific distribution of AG in different tissues of rats and its pharmacokinetic parameter evaluation by using a validated liquid chromatography tandem mass spectrometry (LC-MS/MS) method. Materials and methods: A simple and sensitive LC-MS/MS method has been developed and validated to quantify the presence of AG in plasma and various tissues of rat following oral administration of A. paniculata extract and AG in a dose of 133.33 and 100 mg/kg/day, respectively, for four weeks.Results: The present study showed that the highest concentration of AG was in kidney (156.12 ng/g) followed by liver, spleen and brain while almost same concentration was found in heart and lung. The apparent C max , T max , elimination half-life and total exposure (AUC 0-) were 115.81 ng/ml, 0.75, 2.45 and 278.44 ngh/ml, respectively. Conclusion: This was an attempt to determine the presence of AG (a known biomarker) in tissues such as kidney, heart, lungs, brain and plasma of rats using a validated LC-MS/MS method. Furthermore, the observed reduced concentration in plasma and various tissues from 1 to 8 h might be attributed to relatively rapid elimination or distribution of AG from the central compartment.

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“…1) is the most abundant active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis (FS), a traditional Chinese herb commonly used as astringent and clinically used for the treatment of viral and chemical hepatitis. 1) Previous studies in our laboratory have demonstrated the ability of Sch B to protect against myocardial ischemia/reperfusion (I/R) injury.…”

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confidence: 99%

Schisandrin B-Induced Glutathione Antioxidant Response and Cardioprotection Are Mediated by Reactive Oxidant Species Production in Rat Hearts

Chen

2010

Biological & Pharmaceutical Bulletin

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Schisandrin B (Sch B) ( Fig. 1) is the most abundant active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis (FS), a traditional Chinese herb commonly used as astringent and clinically used for the treatment of viral and chemical hepatitis.1) Previous studies in our laboratory have demonstrated the ability of Sch B to protect against myocardial ischemia/reperfusion (I/R) injury.2) The cardioprotection afforded by Sch B pretreatment was associated with enhancement in tissue glutathione antioxidant status, particularly in the mitochondrion.2-4) Recent studies also showed that Sch B protected against myocardial I/R injury partly by inducing heat shock protein (Hsp) 25 and Hsp 70 expression in rats. 5) In regard to the action on mitochondria, Sch B treatment was found to decrease the sensitivity of myocardial mitochondria to Ca 2ϩ -induced permeability transition, particularly under I/R condition. 6) However, the biochemical mechanism(s) underlying the Sch B-induced glutathione antioxidant and/or heat shock responses in the myocardium remains unclear. In this connection, it has been suggested that reactive oxidant species (ROS) generated from cytochrome P-450 (CYP)-catalyzed reaction with Sch B may trigger the glutathione antioxidant and heat shock responses in mouse livers. 7,8) CYP are a superfamily of hemoproteins that catalyze the oxidative metabolism of many endogenous (endobiotic) and xenobiotic compounds including Sch B.9) To explore the role of CYP in Sch B-induced glutathione antioxidant response in the myocardium, we first examined CYP-catalyzed reaction with Sch B and associated ROS production in rat heart microsomes. Sch B analogs [schisandrin A (Sch A), schisandrin C (Sch C), and dimethyl diphenyl bicarboxylate (DDB)] (see also Fig. 1), which were found to produce differential cardioprotective effects, 10) were also studied for comparison. The in vitro studies were then paralleled by in vivo investigations on Sch B or its analogs-induced changes in myocardial mitochondrial reduced glutathione (GSH) and susceptibility to I/R injury in rats. To confirm the determinant role of ROS arising from Sch B metabolism in cardioprotection, we also examined the effect of antioxidant pretreatment on the cardioprotective action of Sch B in rats. MATERIALS AND METHODS Chemicals

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Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study

Cited by 103 publications

References 19 publications

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Pharmacokinetic analysis and tissue distribution of andrographolide in rat by a validated LC-MS/MS method

Schisandrin B-Induced Glutathione Antioxidant Response and Cardioprotection Are Mediated by Reactive Oxidant Species Production in Rat Hearts

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