The use of computers in education has brought about developments in web technology, and Web 2.0 tools have begun to be used frequently in science lessons. Web 2.0 tools are a technology that allows materials to be developed without space and time limitations, and these materials can be easily shared with students. This study was prepared as a guide material on how to develop the lesson content of the eighth-grade science lesson on physical and chemical change using Web 2.0 tools. All contents about eighth grade physical and chemical change were prepared with Web 2.0 tools, and it was emphasized how to benefit from Web 2.0 tools. With Web 2.0 tools, various tools have been introduced for use in interactive presentations, animations, videos, concept maps, and measurement and evaluation. It is thought that lessons taught with Web 2.0 tools increase students' motivation, permanent learning occurs, and contribute to collaborative learning, and students will actively participate in the process.