Use of whey proteins for encapsulation and controlled delivery applications

Gunasekaran, Sundaram; Ko, Sanghoon; Xiao, Lan

doi:10.1016/j.jfoodeng.2006.11.001

Cited by 295 publications

(195 citation statements)

References 35 publications

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“…35 Similar results were obtained by Jayakrishnan et al 35 where the protease degradation of CAS microspheres crosslinked with a higher amount of glutaraldehyde was slower than that crosslinked with a lower amount. In another study, Gunasekaran et al 34 attributed the resistance of the glutaraldehyde-crosslinked β-lactoglobulin (βLG) nanoparticles against enzymatic attack to their dense crosslinked structure and small portion of basic amino acid composition.…”

Section: Biodegradability Of Cas Nanoparticlesmentioning

confidence: 99%

Novel ionically crosslinked casein nanoparticles for flutamide delivery: formulation, characterization, and in vivo pharmacokinetics

Elzoghby¹,

Helmy²,

Samy³

et al. 2013

IJN

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A novel particulate delivery matrix based on ionically crosslinked casein (CAS) nanoparticles was developed for controlled release of the poorly soluble anticancer drug flutamide (FLT). Nanoparticles were fabricated via oil-in-water emulsification then stabilized by ionic crosslinking of the positively charged CAS molecules below their isoelectric point, with the polyanionic crosslinker sodium tripolyphosphate. With the optimal preparation conditions, the drug loading and incorporation efficiency achieved were 8.73% and 64.55%, respectively. The nanoparticles exhibited a spherical shape with a size below 100 nm and a positive zeta potential (+7.54 to +17.3 mV). FLT was molecularly dispersed inside the nanoparticle protein matrix, as revealed by thermal analysis. The biodegradability of CAS nanoparticles in trypsin solution could be easily modulated by varying the sodium tripolyphosphate crosslinking density. A sustained release of FLT from CAS nanoparticles for up to 4 days was observed, depending on the crosslinking density. After intravenous administration of FLT-CAS nanoparticles into rats, CAS nanoparticles exhibited a longer circulation time and a markedly delayed blood clearance of FLT, with the half-life of FLT extended from 0.88 hours to 14.64 hours, compared with drug cosolvent. The results offer a promising method for tailoring biodegradable, drug-loaded CAS nanoparticles as controlled, long-circulating drug delivery systems of hydrophobic anticancer drugs in aqueous vehicles.

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Section: Biodegradability Of Cas Nanoparticlesmentioning

confidence: 99%

Novel ionically crosslinked casein nanoparticles for flutamide delivery: formulation, characterization, and in vivo pharmacokinetics

Elzoghby¹,

Helmy²,

Samy³

et al. 2013

IJN

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show abstract

“…At higher protein concentration, the cross-linking density of the microgel network was higher, leading to a decrease in the swelling ratio. Hence, it takes 562 longer for particles to swell and liberate the encapsulated substance, which can be a strategy 563 for slow release Gunasekaran, et al, 2007 "Emulsion gels", also named as "emulsion hydrogel", "emulgel", "emulsion-filled gel" are defined as soft solids where emulsified lipid droplets are entrapped in a gel matrix. Generally, the emulsified lipid droplets are referred to as "fillers" and the gelled aqueous phase is referred to as the "matrix".…”

mentioning

confidence: 99%

Emulsion microgel particles: Novel encapsulation strategy for lipophilic molecules

Torres

Murray

Sarkar

2016

Trends in Food Science & Technology

179

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“…Maltodekstrin adalah polisakarida yang memiliki sifat yang baik sebagai bahan enkapsulan, aman, tidak toksis, dan memiliki batas penggunaan maksimumnya CPP (jumlah yang diperlukan secukupnya untuk menghasilkan efek yang diinginkan) (BPOM, 2013). Selain maltodekstrin, bahan penyalut seperti protein juga dapat digunakan karena sifat yang dapat membentuk gel sehingga memungkinkan sebagai bahan enkapsulasi zat aktif baik lipofilik maupun hidrofilik (Gunasekaran et al, 2007). Selain itu, menurut Chen et al (2006) protein juga melindungi senyawa aktif yang sensitif terhadap kondisi di saluran pencernaan, sehingga dapat menjadi penghantar zat aktif secara terkontrol.…”

Section: Hasil Spray Drying Nanopartikel Ekstrak Kulit Manggisunclassified

Sintesis Nanopartikel Ekstrak Kulit Manggis Merah Dan Kajian Sifat Fungsional Produk Enkapsulasinya

Ningsih

Yasni

Yuliani

2017

jtip

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Utilization of mangosteen fruit waste tends to be less practical, so nanoparticle based encapsulation is an effective approach. The objective if this research was to utilize the waste from the red mangosteen peel Garcinia forbesii (GF) and Garcinia mangostana (GM ABSTRAKPemanfaatan limbah kulit buah manggis cenderung kurang praktis, sehingga enkapsulasi berbasis nanopartikel merupakan pendekatan yang efektif. Tujuan penelitian ini adalah pemanfaatan limbah kulit manggis merah Garcinia forbesii (GF) dan Garcinia mangostana (GM) untuk menghasilkan nanopartikel ekstrak, produk enkapsulasinya, dan mengetahui sifat fungsionalnya. Penelitian ini terdiri dari tiga tahap, yaitu ekstraksi, sintesis nanopartikel, dan enkpasulasi. Parameter yang digunakan adalah rendemen ekstrak, nilai fungsional antioksidan dan Total Senyawa Fenol (TSF), ukuran partikel, indeks polidispersitas, dan morfologi permukaan enkapsulat. Sintesis nanopartikel dilakukan menggunakan metode gelasi ionik. Perhitungan nilai fungsional menggunakan konsentrasi ekstrak sebesar 10% dalam larutan nanopartikel. Hasil penelitian menunjukkan bahwa menggunakan metode refluks memberikan hasil yang lebih baik dibandingkan dengan metode maserasi. Formula 2 nanopartikel dengan konsentrasi kitosan 0,2% dan STPP 0,1% dan produk enkapsulasinya dengan bahan penyalut Maltodekstrin Kasein (MK) memberikan hasil yang terbaik dengan peningkatan nilai fungsional.Kata kunci: enkapsulasi, kulit manggis merah, nanopartikel PENDAHULUAN1Salah satu buah Indonesia yang potensial berkhasiat bagi kesehatan adalah buah manggis. Walaupun kulit buah manggis tergolong dalam limbah, namun mengandung senyawa zat aktif yang berkhasiat bagi kesehatan. Buah manggis ada berbagai jenis, salah satunya manggis merah (Garcinia forbesii) atau dikenal dengan nama mundar dan

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Use of whey proteins for encapsulation and controlled delivery applications

Cited by 295 publications

References 35 publications

Novel ionically crosslinked casein nanoparticles for flutamide delivery: formulation, characterization, and in vivo pharmacokinetics

Novel ionically crosslinked casein nanoparticles for flutamide delivery: formulation, characterization, and in vivo pharmacokinetics

Emulsion microgel particles: Novel encapsulation strategy for lipophilic molecules

Sintesis Nanopartikel Ekstrak Kulit Manggis Merah Dan Kajian Sifat Fungsional Produk Enkapsulasinya

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