Use of Zirconia Ceramic in the DexAide Right Ventricular Assist Device Journal Bearing

Saeed, Diyar; Horvath, David J.; Massiello, Alex; Ootaki, Yoshio; Benefit, Stephen; Golding, Leonard A.R.; Fukamachi, Kiyotaka

doi:10.1111/j.1525-1594.2009.00757.x

Cited by 4 publications

(6 citation statements)

References 6 publications

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“…There was a statistically significant difference in the motor consumption between the DexAide RVAD experiments with zirconia stators and prior DexAide experiments with titanium stators ( P < 0.001). We have reported previously the material properties of zirconia that makes it a suitable material for blood pumps and shown in our in vitro development efforts that the new DexAide RVAD zirconia stator extended battery life by 3 h and 20 min to over 12 h (4).…”

Section: Discussionmentioning

confidence: 99%

In Vivo Evaluation of Zirconia Ceramic in the DexAide Right Ventricular Assist Device Journal Bearing

Saeed¹,

Shalli²,

Fumoto³

et al. 2010

Artificial Organs

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Zirconia is a ceramic with material properties ideal for journal bearing applications. The purpose of this study was to evaluate the use of zirconium oxide (zirconia) as a blood journal bearing material in the DexAide right ventricular assist device. Zirconia ceramic was used instead of titanium to manufacture the DexAide stator housing without changing the stator geometry or the remaining pump hardware components. Pump hydraulic performance, journal bearing reliability, biocompatibility, and motor efficiency data of the zirconia stator were evaluated in six chronic bovine experiments for 14-91 days and compared with data from chronic experiments using the titanium stator. Pump performance data including average in vivo pump flows and speeds using a zirconia stator showed no statistically significant difference to the average values for 16 prior titanium stator in vivo studies, with the exception of a 19% reduction in power consumption. Indices of hemolysis were comparable for both stator types. Results of coagulation assays and platelet aggregation tests for the zirconia stator implants showed no device-induced increase in platelet activation. Postexplant evaluation of the zirconia journal bearing surfaces showed no biologic deposition in any of the implants. In conclusion, zirconia ceramic can be used as a hemocompatible material to improve motor efficiency while maintaining hydraulic performance in a blood journal bearing application.

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Section: Discussionmentioning

confidence: 99%

In Vivo Evaluation of Zirconia Ceramic in the DexAide Right Ventricular Assist Device Journal Bearing

Saeed¹,

Shalli²,

Fumoto³

et al. 2010

Artificial Organs

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“…Subsequent i n vitro 96 and 14 to 91-day experiments 99 demonstrated that the new zirconia ceramic stator reduced power consumption by 20% with similar hemodynamic performance to the original cast-titanium stator. No biological deposition was observed on the new stator, which suggests that zirconia ceramic may be a useful material in the journal bearings of novel LVADs.…”

Section: Right Ventricular Assist Devicesmentioning

confidence: 98%

“…The DexAide contains a cast-titanium volute housing (44 × 48 mm, 69 ml volume displacement, 280 g), a rotating magnetic ring with impeller veins, and a zirconia (zirconium oxide) ceramic stator 96 (Figure 2, Right). The rotating assembly spins around the stator post suspended in the axial direction by magnetic forces and in the radial direction by a blood lubricated film 97 .…”

Section: Right Ventricular Assist Devicesmentioning

confidence: 99%

“…The outflow cannula is anastomosed end-to-side to the trunk of the pulmonary artery. A driveline is externalized to a portable electronics module powered through a standard wall socket or two nickel-metal hydride batteries, which may provide up to 12 hours of support 96 . Currently, Cleveland Heart is seeking an FDA IDE for the DexAide RVAD 13 .…”

Section: Right Ventricular Assist Devicesmentioning

confidence: 99%

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The Future of Adult Cardiac Assist Devices: Novel Systems and Mechanical Circulatory Support Strategies

Bartoli

Dowling

2011

Cardiology Clinics

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Synopsis The recent, widespread success of mechanical circulatory support has ushered in a new era of cardiovascular medicine in which numerous implantable devices exist to treat advanced heart failure. As cardiac assist devices gain prevalence in the clinical management of cardiovascular disease, it is increasingly important to raise awareness of novel device systems, the unique mechanisms by which they function, and implications for patient management. In this article, we present state-of-the-art devices that are currently under development or in clinical trials. Devices are categorized as Standard Full-Support (HeartMate III, CorAide, Evaheart LVAS), Less-Invasive Full-Support (MVAD), Partial-Support (CircuLite Synergy Pocket Micro-Pump, Reitan Catheter Pump, Procyrion CAD, C-Pulse, Symphony Counterpulsation Device) Right Ventricular Assist Device (RVAD; DexAide, Impella RD Recover, Impella RP), and Total Artificial Heart (TAH; CardioWest, AbioCor II, Continuous-Flow TAH, Continuous-Flow BiVAD). Implantation strategy, mechanism of action, durability, efficacy, hemocompatibility, and human factors such as quality of life during device support are considered. The feasibility of novel strategies for unloading the failing heart is examined.

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“…5,6 Circulatory assist devices are rapidly becoming a viable therapeutic option for end-stage heart failure and are being increasingly used in elderly patients. 7 Even with the reported significant improvements in the new continuous-flow ventricular assist devices over their pulsatile predecessors, thromboembolism and bleeding associated with anticoagulation use remain two of the major complications associated with these devices.…”

Section: Commentsmentioning

confidence: 99%

In Vivo Evaluation of a New Surfactant Polymer Coating Mimicking the Glycocalyx of Endothelial Cells

et al. 2011

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The purpose of the current study was to demonstrate that a proprietary surfactant polymer coating does not adversely affect the hemodynamic performance of cardiopulmonary bypass (CPB) or gas exchange in oxygenators. The new coating was applied to a CPB circuit including cannulae, reservoir, oxygenator, and blood pump implanted into 12 pigs, divided into groups with either coated or noncoated pumps. CPB flow was maintained at a fixed level of approximately 2.4 L/min for 6 hrs with full heparinization. Hemodynamic data and pump performance were recorded every hour, and blood samples were taken every 2 hrs. After sacrifice, the CPB circuit and major organs were macroscopically examined. There was no significant difference in the oxygen transfer rate between the two groups. The coating did not adversely affect oxygenator inlet or outlet pressures. There was no significant difference between the two groups in microthrombi seen in the oxygenators. No thromboemboli were noted in the major organs on gross or histologic examination. In conclusion, this new surfactant polymer coating did not decrease gas exchange performance and its biocompatibility evaluations revealed no differences between coated and noncoated groups under aggressive heparin use.

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Use of Zirconia Ceramic in the DexAide Right Ventricular Assist Device Journal Bearing

Cited by 4 publications

References 6 publications

In Vivo Evaluation of Zirconia Ceramic in the DexAide Right Ventricular Assist Device Journal Bearing

In Vivo Evaluation of Zirconia Ceramic in the DexAide Right Ventricular Assist Device Journal Bearing

The Future of Adult Cardiac Assist Devices: Novel Systems and Mechanical Circulatory Support Strategies

In Vivo Evaluation of a New Surfactant Polymer Coating Mimicking the Glycocalyx of Endothelial Cells

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