Useful preoperative examination findings to classify the grade of ovarian primary mucinous tumor

Ohya, Ayumi; Ichinohe, Fumihito; Matoba, Hisanori; Kobara, Hisanori; Fujinaga, Yasunari

doi:10.1007/s00261-020-02918-4

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Ohya et al. ( 60 ) suggest that serum CEA levels exceeding twice the threshold value can be used to differentiate malignant from benign tumors, whereas CA-19-9 levels above the cut-off could be used to identify borderline tumors.…”

Section: Moc Diagnosis and Differential Diagnosismentioning

confidence: 99%

Multimodal diagnostic strategies and precision medicine in mucinous ovarian carcinoma: a comprehensive approach

Wang,

Peng,

et al. 2024

Front. Oncol.

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Mucinous ovarian carcinoma (MOC) represents a distinct entity within ovarian malignancies, characterized by diagnostic challenges due to its rarity and the potential overlap with other tumor types. The determination of tumor origin is important for precise postsurgical treatment. This article highlights the accurate diagnosis and management of MOC, including the use of imaging modalities, serological tumor markers, immunohistochemistry, and genomic analyses. Transabdominal and transvaginal ultrasonography, complemented by MRI and CT, plays a pivotal role in differentiating MOC from other mucinous tumors and in surgical planning, particularly for fertility preservation. Serological markers like CA19-9, CA-125, and CEA, though not definitive, provide valuable preoperative insights. Immunohistochemistry aids in distinguishing primary MOC from metastatic mucinous carcinomas, while genomic profiling offers the potential for precision medicine through the identification of specific molecular signatures and treatment susceptibilities. Despite advancements in diagnostic techniques, no single method conclusively differentiates between primary and metastatic tumors intraoperatively. The paper reviews the origins, diagnosis, and differential diagnosis of primary mucinous ovarian carcinoma highlights the need for a multimodal diagnostic approach and advocates for the inclusion of MOC patients in clinical trials for personalized therapies, recognizing the heterogeneity of the disease at the molecular level.

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Section: Moc Diagnosis and Differential Diagnosismentioning

confidence: 99%

Multimodal diagnostic strategies and precision medicine in mucinous ovarian carcinoma: a comprehensive approach

Wang,

Peng,

et al. 2024

Front. Oncol.

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“…3 ). However, a recent study found similar numbers of loculi in mucinous borderline tumor, mucinous carcinoma, and mucinous cystadenoma, with 50% of mucinous carcinoma lacking solid components [ 19 ]. Mucinous borderline tumor and mucinous carcinoma without a solid component have an O-RADS MRI score of 3, and might be underestimated as a benign lesion [ 4 , 5 ].…”

Section: Multilocular Cystic Massesmentioning

confidence: 99%

“…Mucinous borderline tumor and mucinous carcinoma without a solid component have an O-RADS MRI score of 3, and might be underestimated as a benign lesion [ 4 , 5 ]. Recent study has focused on the intensity of cyst contents in addition to the number of loculi and solid components when grading mucinous tumors on MRI [ 19 ]. It was reported that a combination of hyperintense loculi on T1WI and hypointense loculi on T2WI suggests a high possibility of borderline or malignant mucinous tumor (Fig.…”

Section: Multilocular Cystic Massesmentioning

confidence: 99%

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Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice

Ohya

Fujinaga

2022

Jpn J Radiol

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There are many types of ovarian tumors, and these different types often form cystic masses with a similar appearance, which can make their differentiation difficult. However, with the exclusion of rare ovarian tumors, the number of ovarian tumors encountered in daily practice is somewhat fixed. It goes without saying that magnetic resonance imaging (MRI) is useful for differentiating ovarian tumors. In this review, we summarize the differential diagnoses for each of the five types of MRI findings commonly encountered in daily practice. First, unilocular cystic masses without mural nodules/solid components include benign lesions such as serous cystadenoma, functional cysts, surface epithelial inclusion cysts, paratubal cysts, and endometriosis. Second, multilocular cystic ovarian lesions include mucinous tumors and ovarian metastases. It should be noted that mucinous tumors may be diagnosed as borderline or carcinoma, even if no solid component is observed. Third, cystic lesions with mural nodules that are unrelated to endometriosis include serous borderline tumor and serous carcinoma. Cystic lesions with solid components are more likely to be malignant, but some may be diagnosed as benign. Fourth, ovarian tumors deriving from endometriosis include seromucinous borderline tumors, endometrioid carcinoma, and clear cell carcinoma. These tumors sometimes need to be differentiated from serous tumors. Finally, cystic lesions with lipid contents include teratoma-related tumors. In mature cystic teratoma, mural nodules (called “Rokitansky protuberance” or “dermoid nipple”) are sometimes seen, but they do not suggest malignancy. Some of these lesions can be diagnosed accurately by considering their characteristic imaging findings, their changes over time, MRI findings other than those of the primary lesion, and information from other modalities such as tumor markers. To ensure the optimal treatment for ovarian tumors, it is important to estimate the histological type as well as to diagnose whether a lesion is benign or malignant.

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Salient magnetic resonance imaging findings in the differential diagnosis of benign, borderline and malignant ovarian mucinous tumors

Ozyilmaz,

Kulali,

Topal

et al. 2024

Abdom Radiol

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Useful preoperative examination findings to classify the grade of ovarian primary mucinous tumor

Cited by 7 publications

References 17 publications

Multimodal diagnostic strategies and precision medicine in mucinous ovarian carcinoma: a comprehensive approach

Multimodal diagnostic strategies and precision medicine in mucinous ovarian carcinoma: a comprehensive approach

Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice

Salient magnetic resonance imaging findings in the differential diagnosis of benign, borderline and malignant ovarian mucinous tumors

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