Usefulness of 99m-Tc-sestamibi scintimammography in suspected breast cancer and in axillary lymph node metastases detection

Lumachi, Franco; Ferretti, Guido; Povolato, Michele; Marzola, Maria Cristina; Zucchetta, Pietro; Geatti, Onelio; Bui, Franco; Brandes, Alba A.

doi:10.1053/ejso.2000.1096

Cited by 29 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such findings were different from those of Lumachi et al. They reported age did not affect the sensitivity of sestamibi scintimammography (16). There were five false‐negative cases in our study, four from the younger‐than‐50‐years group and one from the 50‐years‐or‐older group.…”

Section: Discussioncontrasting

confidence: 84%

Effectiveness of Breast-Specific Gamma Imaging (BSGI) for Breast Cancer in Korea: A Comparative Study

Lee¹,

Chang²,

Lim³

et al. 2012

The Breast Journal

View full text Add to dashboard Cite

Despite the fact that mammography has been the golden standard in breast cancer detection for several decades, its sensitivity decreases for women with dense breast tissue, which happens to be common in Korea. As an alternative, breast ultrasonography can be effective diagnostic modalities that complement the defect of mammography. Recently, breast-specific gamma imaging (BSGI) has been introduced as a new diagnostic modality for breast cancer. This study was designed to analyze the effectiveness of BSGI in particular. In a retrospective study, 471 patients underwent BSGI, breast ultrasonography, and mammography simultaneously during the period between February 2009 and March 2010. The indications of BSGI were as follows: (a) patient who was diagnosed with malignancy prior to surgery, (b) patient who is under follow up after cancer surgery, (c) patient with lesions which cannot be evaluated by breast ultrasonography or mammography, (d) patient with multiple benign lesions, and (e) patient with suspicious lesion who refuses biopsy. Among these patients, 121 patients underwent biopsy, whereas others were followed up with imaging studies. We compared the BSGI results with those of mammography, breast ultrasonography, and pathology. The mean age of the patients was 49.63 ± 10.43 years. There were 107 patients with 110 malignant lesions and 364 patients with benign lesions. Total 474 lesions were evaluated. The sensitivities of BSGI, mammography, and breast ultrasonography were 94.45%, 93.64%, and 98.18%, respectively, whereas the specificities of BSGI, mammography, and breast ultrasonography were 90.93%, 90.66%, and 87.09%, respectively. The sensitivity and specificity of BSGI for axillary lymph node (LN) status were 44.7 4% and 87.88%, respectively. BSGI is a good complementary imaging modality with high sensitivity and high specificity for breast cancer detection. However, it has low efficacy for the evaluation for axillary LN status.

show abstract

Section: Discussioncontrasting

confidence: 84%

Effectiveness of Breast-Specific Gamma Imaging (BSGI) for Breast Cancer in Korea: A Comparative Study

Lee¹,

Chang²,

Lim³

et al. 2012

The Breast Journal

View full text Add to dashboard Cite

show abstract

“…Even though, there are posterior and recent publications with new results still reporting relatively good values [17,25-28]. Limachi et al [27] reported lower sensitivity if fewer nodes were affected, similar to our findings (in patients with <3 metastases, sensitivity was 69.7%, and only one out of six patients with a single lesion had a positive scan). See Table 3.…”

Section: Discussionsupporting

confidence: 89%

Planar Tc99m – sestamibi scintimammography should be considered cautiously in the axillary evaluation of breast cancer protocols: Results of an international multicenter trial

et al. 2005

View full text Add to dashboard Cite

Background: Lymph node status is the most important prognostic indicator in breast cancer in recently diagnosed primary lesion. As a part of an interregional protocol using scintimammography with Tc99m compounds, the value of planar Tc99m sestamibi scanning for axillary lymph node evaluation is presented. Since there is a wide range of reported values, a standardized protocol of planar imaging was performed.

show abstract

“…A preoperative knowledge of node positivity is seen by some as an indication for neo-adjuvant chemotherapy. The imaging techniques that have been extensively investigated to assess the axilla preoperatively are US with a reported sensitivity of 56 -72% and a specificity of 70 -90% (Bruneton et al, 1986;de Freitas et al, 1991;Vaidya et al, 1996;Feu et al, 1997), scintimammography with a sensitivity of 67 -100% and a specificity of 80 -90% (Dupont et al, 2001;Lumachi et al, 2001), CT with a sensitivity of 90% and a specificity of 82% (March et al, 1991;Uematsu et al, 2001) and colour Doppler with a sensitivity of 76% (Yang et al, 2000(Yang et al, , 2001. The sensitivity and specificity achieved using these techniques does not allow a reliable selection of patients for full axillary clearance or a more minimally invasive procedure.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of axillary nodal metastases by ultrasound-guided core biopsy in primary operable breast cancer

et al. 2003

View full text Add to dashboard Cite

The purpose of this study was to examine the use of ultrasound (US)-guided core biopsy of axillary nodes in patients with operable breast cancer. The ipsilateral axillae of 187 patients with suspected primary operable breast cancer were scanned. Nodes were classified based on their shape and cortical morphology. Abnormal nodes underwent US-guided core biopsy/fine needle aspiration (FNA), and the results correlated with subsequent axillary surgery. The nodes were identified on US in 103 of 166 axillae of patients with confirmed invasive carcinoma. In total, 54 (52%) met the criteria for biopsy: 48 core biopsies (26 malignant, 20 benign node, two normal) and six FNA were performed. On subsequent definitive histological examination, 64 of 166 (39%) had axillary metastases. Of the 64 patients with involved nodes at surgery, preoperative US identified nodes in 46 patients (72%), of which 35 (55%) met the criteria for biopsy and 27 (42%) of these were diagnosed preoperatively by US-guided biopsy. In conclusion, US can identify abnormal nodes in patients presenting with primary operable breast cancer. In all, 65% of these nodes are malignant and this can often be confirmed with US-guided core biopsy.

show abstract

Usefulness of 99m-Tc-sestamibi scintimammography in suspected breast cancer and in axillary lymph node metastases detection

Cited by 29 publications

References 19 publications

Effectiveness of Breast-Specific Gamma Imaging (BSGI) for Breast Cancer in Korea: A Comparative Study

Effectiveness of Breast-Specific Gamma Imaging (BSGI) for Breast Cancer in Korea: A Comparative Study

Planar Tc99m – sestamibi scintimammography should be considered cautiously in the axillary evaluation of breast cancer protocols: Results of an international multicenter trial

Diagnosis of axillary nodal metastases by ultrasound-guided core biopsy in primary operable breast cancer

Contact Info

Product

Resources

About