Usefulness of a blood flow analyzing program 3DSRT to detect occipital hypoperfusion in dementia with Lewy bodies

Tateno, Masaru; Utsumi, Kumiko; Kobayashi, Seiju; Takahashi, Akira; Saitoh, Masaki; Morii, Hidetoshi; Fujii, Kazuki; Teraoka, Masatoshi

doi:10.1016/j.pnpbp.2008.03.006

Cited by 21 publications

(26 citation statements)

References 21 publications

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“…The presence and absence of fluctuations in cognition and attention was carefully assessed by obtaining information from reliable caregivers. All the patients were right-handed Japanese and most of them participated in our previous study [4] . None of them were taking any medications which affect brain blood perfusion or cardiac MIBG uptake [5,6] , and none had a history of cardiovascular diseases or diabetes mellitus.…”

Section: Subjectsmentioning

confidence: 99%

“…Quantitative flow-mapping images were obtained from the qualitative perfusion images by using Patlak plot graphical analysis and Lassen's correction [10] . Regional CBF (rCBF) was quantified using an automated brain perfusion SPECT analyzing program, 3DSRT [4,11,12] . This program includes anatomic standardization of images employing statistical parametric mapping (SPM) [13] only for that purpose, rCBF quantification using a three-dimensional stereotactic region of interest (ROI) template, calculation of CBF, and display of the results.…”

Section: Subjectsmentioning

confidence: 99%

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Comparison of the Usefulness of Brain Perfusion SPECT and MIBG Myocardial Scintigraphy for the Diagnosis of Dementia with Lewy Bodies

Tateno

Kobayashi²,

Shirasaka³

et al. 2008

Dement Geriatr Cogn Disord

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Background: Supportive features in the diagnostic criteria for dementia with Lewy bodies (DLB) include occipital hypoperfusion and decreased cardiac uptake of ¹²³I-metaiodobenzylguanidine (MIBG). In this study, we performed both brain perfusion single photon emission computed tomography (SPECT) and MIBG myocardial scintigraphy in the same subjects and evaluated their sensitivity to detect the characteristic features of DLB. Methods: Twenty-five patients with probable DLB (76.8 ± 5.1 years old, 10 male) underwent ^99mTc-ethylcysteinate dimer brain perfusion SPECT and ¹²³I-MIBG myocardial scintigraphy. The results of SPECT were analyzed using a qualitative analysis program, easy Z score imaging system (eZIS), and an automated quantitative analysis program, 3DSRT. Results: Qualitative analysis using eZIS demonstrated occipital hypoperfusion in 17 subjects (68%). The quantified mean blood perfusion in the occipital segment on the 3DSRT template was 40.7 ± 5.03 ml/100 g/min (right) and 40.5 ± 5.38 ml/100 g/min (left), and in 19 DLB patients these values were below the normal limit. Twenty-four of 25 subjects (96%) had decreased cardiac MIBG uptake in the delayed image. Conclusion: MIBG myocardial scintigraphy was superior to brain perfusion SPECT in detecting a characteristic feature of DLB. Our results suggest that combining SPECT and MIBG scintigraphy could increase the accuracy of clinical diagnosis of DLB.

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Section: Subjectsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Comparison of the Usefulness of Brain Perfusion SPECT and MIBG Myocardial Scintigraphy for the Diagnosis of Dementia with Lewy Bodies

Tateno

Kobayashi²,

Shirasaka³

et al. 2008

Dement Geriatr Cogn Disord

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“…3DSRT is fully automated ROI-based analysis software for the brain. It was established to perform ROI analysis of the brain with improved objectivity and excellent reproducibility [4,5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

Glucose Metabolism in the Primary Auditory Cortex of Postlingually Deaf Patients: An FDG-PET Study

Okuda

Nagamachi²,

Ushisako³

et al. 2013

ORL

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Background/Purpose: Previous FDG-PET studies have indicated neuroplasticity in the adult auditory cortex in cases of postlingual deafness. In the mature brain, auditory deprivation decreased neuronal activity in primary auditory and auditory-related cortices. In order to reevaluate these issues, we used statistical analytic software, namely a three-dimensional stereotaxic region of interest template (3DSRT), in addition to statistical parametric mapping (SPM; Institute of Neurology, University College of London, UK). MaterialsandMethods:¹⁸F-FDG brain PET scans were performed on 7 postlingually deaf patients and 10 healthy volunteers. Significant increases and decreases of regional cerebral glucose metabolism in the patient group were estimated by comparing their PET images with those of healthy volunteers using SPM analysis and 3DSRT. Results: SPM revealed that the glucose metabolism of the deaf patients was lower in the right superior temporal gyrus, both middle temporal gyri, left inferior temporal gyrus, right inferior lobulus parietalis, right posterior cingulate gyrus, and left insular cortex than that of the control subjects. 3DSRT data also revealed significantly decreased glucose metabolism in both primary auditory cortices of the postlingually deaf patients. Conclusion: SPM and 3DSRT analyses indicated that glucose metabolism decreased in the primary auditory cortex of the postlingually deaf patients. The previous results of PET studies were confirmed, and our method involving 3DSRT has proved to be useful.

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“…Mean uptake values are averaged within these regions and compared within or between subjects [12]. Quantitative methods, such as the automated multi-ROI programme 3DSRT [13,14], statistical parametric mapping [15][16][17], discriminant function analysis [18][19][20], three-dimensional stereotactic surface projection [21] and neural network analysis [22][23][24][25][26] have been added to the research tools available in PET and SPECT. Adding structural information from MRI or CT improves clinical and research interpretations of functional scans [19,[27][28][29][30].…”

Section: Image Analysis Methodsmentioning

confidence: 99%

Is there Still a Place for Perfusion SPECT in the Diagnosis of Dementia?

Ebmeier

2010

TONMEDJ

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Abstract:Although research interest within functional imaging has moved towards applications of MRI, such as BOLD and perfusion imaging, there is a wealth of clinical experience in emission tomographic imaging techniques that make the use of these modalities relevant for the decades to come. This review touches upon the technical and practical issues that distinguish SPECT from PET, describes perfusion and metabolic changes observed in the dementias, compares the clinical utility of the two techniques, and reports data on clinical sensitivity and specificity, as well as diagnostic head-to head comparisons in dementia, and specifically Alzheimer's disease. While few centres have a genuine choice between PET and SPECT, either appears to be good enough to help with the differential diagnosis of dementia in difficult cases.

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Usefulness of a blood flow analyzing program 3DSRT to detect occipital hypoperfusion in dementia with Lewy bodies

Cited by 21 publications

References 21 publications

Comparison of the Usefulness of Brain Perfusion SPECT and MIBG Myocardial Scintigraphy for the Diagnosis of Dementia with Lewy Bodies

Comparison of the Usefulness of Brain Perfusion SPECT and MIBG Myocardial Scintigraphy for the Diagnosis of Dementia with Lewy Bodies

Glucose Metabolism in the Primary Auditory Cortex of Postlingually Deaf Patients: An FDG-PET Study

Is there Still a Place for Perfusion SPECT in the Diagnosis of Dementia?

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