Usefulness of a Novel Electrocardiographic Score to Estimate the Pre-Test Probability of Acute Pulmonary Embolism

Abstract

According to our experience the 12-lead electrocardiogram (ECG) may be used to estimate the pretest probability of acute pulmonary embolism (acPE). To this end, we devised a novel ECG score (nECGs) composed of 5 known ECG criteria, best characterizing the key pathogenetic steps of acPE. A retrospective derivation cohort including 136 patients with acPE and a prospective validation cohort including 149 consecutive patients were used to devise and validate the nECGs. The latter cohort consisted of 76 patients with acPE and 73 controls presenting with characteristic symptoms of acPE, in whom the work-up ruled out acPE. We compared the diagnostic value of our nECGs with those of another ECG score (Daniel-ECG-score) and of the best prediction rules (3 Wells score and 2 Geneva score variants). The sensitivity (98.7%), negative predictive value (98%), test accuracy (84.4%) and the negative likelihood ratio (LR) (0.019) of the nECGs were superior to those of all other investigated methods. There was no between-groups difference in the positive LR. The specificity (69%) of the nECGs was inferior to those of the Daniel-ECG-score and Wells scores and did not differ or was superior to those of the Geneva score variants. The positive predictive value (77.3%) of the nECGs was superior to those of the 2 Geneva scores and did not differ from those of the other methods. In conclusion, the nECGs due to its superior sensitivity, negative predictive value, test accuracy, and negative LR estimated the pretest probability of acPE better than the Daniel-ECGscore and the prediction rules.

The Utility of a Resting Electrocardiogram (ECG-PH Index) in Evaluating the Efficacy of Pulmonary Endarterectomy in Chronic Thromboembolic Pulmonary Hypertension

“…The diagnostic value of the resting ECG was also evaluated in patients with acute pulmonary embolism, not only with regard to the prognosis in the acute phase but also to screening for CTEPH [26][27][28][29][30][31][32]. In addition, the ECG curve was also examined for its ability to differentiate between proximal and distal CTEPH localization [33].…”

“…Recent studies on acute pulmonary thromboembolism have assessed and compared various ECG scores for use in patients undergoing diagnostics due to suspected acute pulmonary embolism, e.g., Daniel-ECG score and novel ECG score [29,30]. However, both scales require the analysis of a large number of electrocardiographic parameters, making them difficult to use in everyday clinical practice.…”

(Pulmonary embolism in the Tábor region - revised Geneva score and other predictors of PE on CT pulmonary angiogram)

“…Ve snaze zvýšit záchyt PE na CT angiografi i, a omezit tak počet zbytečných negativních CTPA byly zkoušeny edukace, 12 elektronické rozhodovací pomůcky 15 či EKG 16,17 nebo kombinované rozhodovací nástroje vytvořené pomocí strojového učení, 8,18 případně generovaného pomocí poloautomatického zpracování zdravotnických dat. 9 Výsledky metod strojového učení jsou v daném klinickém kontextu lepší než RGS (v práci Silvy, 2023 -model derivovaný metodou strojového učení z EKG, klinických a laboratorních parametrů AUC 0,75 se 100% senzitivitou vs. kombinace RGS a DD s AUC 0,51).…”