Usefulness of Alpha 1 Acid Glycoprotein (&amp;alpha;1-AG) Values in Screening Pound Dogs Acquired from Animal Shelters for Experimental Use

Ohwada, Kazuo; Tamura, Keiji

doi:10.1538/expanim1978.42.4_627

Cited by 16 publications

(11 citation statements)

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“…No significant difference was observed with regard to sex, and both sexes had lower mean values than those obtained from dogs with inflammatory diseases [3,6,10,21,24,28], matching well with previously reported values [3,6]. Thus, the results of our study suggest that we did indeed obtain physiological AAG levels in healthy beagles.…”

Section: Discussionsupporting

confidence: 91%

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Alpha 1-Acid Glycoprotein (AAG) Levels in Healthy and Pregrant Beagle Dogs

et al. 2003

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Abstract. Serum alpha 1-acid glycoprotein (AAG) levels were measured in healthy beagles of various ages (66 male and 74 female) by turbidimetric immunoassay (TIA), and then separately -in pregnant beagles -by single radial immunodiffusion (SRID). The first experiment revealed that serum AAG levels ranged from 40 to 960 µg/ml (mean of 322 ± 202 µg/ml) in male dogs, and from 47 to 833 µg/ml -in female dogs (mean of 316 ± 199 µg/ ml), without any significant sex-or age-related variation. The second experiment, however, revealed that serum AAG levels increased in all pregnant beagles and peaked in the middle of gestation at 250-1,000 µg/ml (mean of 634 ± 246 µg/ml). In 7 of 8 dogs the AAG levels peaked about 45 days after ovulation. Despite a high value of 1,210-1,360 µg/ml being observed for serum AAG levels in 3 pregnant beagles inoculated with Staphylococcus aureus, its levels in umbilical cord blood were below the detection limit of SRID (40 µg/ml).

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Section: Discussionsupporting

confidence: 91%

“…The serum AAG levels in pregnant dogs and in umbilical cord blood were measured according to Ohwada and Tamura [21] and Rikihisa et al [24] using a commercial SRID kit (The Institute for Metabolic Ecosystem Co., Ltd., Furukawa, Japan) with an AAG detection limit of 40 µg/ml.…”

Section: Measurement Of Aag Levels In Pregnant Dogs and In Umbilical mentioning

confidence: 99%

Alpha 1-Acid Glycoprotein (AAG) Levels in Healthy and Pregrant Beagle Dogs

et al. 2003

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“…A very interesting characteristic of APPs is the possibility of detecting subclinical disease and predicting possible future clinical disease in the animal. For example, measurement of AGP in a health screen was useful for identifying dogs with subclinical disease that, after 2 weeks, had clinical signs or even died of different causes such as parvovirus infection 103…”

Section: Clinical Value Of Acute Phase Protein Determinationmentioning

confidence: 99%

Acute phase proteins in dogs and cats: current knowledge and future perspectives

Cerón

Eckersall²,

Martı́nez-Subiela³

2005

Veterinary Clinical Pathol

657

737

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The acute phase response is a nonspecific inflammatory reaction of the host that occurs shortly after any tissue injury. The response includes changes in the concentration of plasma proteins called acute phase proteins (APPs), some of which decrease in concentration (negative APPs), such as albumin or transferrin, and others of which increase in concentration (positive APPs), such as C-reactive protein, serum amyloid A, haptoglobin, alpha-1-acid glycoprotein, and ceruloplasmin. Most positive APPs are glycoproteins synthesized mainly by hepatocytes upon stimulation by proinflammatory cytokines and released into the bloodstream. The acute phase response and clinical application of monitoring APPs in dogs and cats are reviewed in this article, including biochemical characteristics, assays developed for each individual APP, and preanalytic and analytic factors influencing APP results that should be taken into account for proper and adequate clinical interpretation. In addition, the diagnostic use of APPs and their possible application in monitoring treatment, which can be considered one of the most interesting and promising practical applications of these proteins, will be discussed. Finally, challenges and future developments of APPs in dogs and cats will be considered, because it is expected that new and cheaper automated assays for determination of the main APPs in small animals will contribute to a wider use of these proteins as biomarkers of infection and inflammatory lesions.

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“…Additionally, AGP concentrations increase in dogs with inflammatory or neoplastic diseases, and the clinical value of AGP analysis for determination of prognosis in animals with malignant tumors has been proposed 10–12 . Analysis of AGP has also been reported to be useful in differentiating diseased from healthy shelter dogs 13 …”

Section: Introductionmentioning

confidence: 99%