Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Isah, Isoken A; Sadoh, Wilson E.; Iduoriyekemwen, Nosakhare J.

doi:10.21037/cdt.2017.05.08

Cited by 6 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of our MIS-C patients, 1 had acquired heart disease and 3 had congenital heart disease. The proBNP levels were higher in patients with heart disease compared with the healthy population [ 16 ]. However, on examining the published studies on this topic, the proBNP levels were generally lower than 1000 ng/L in patients with heart failure with left-to-right shunt [ [16] , [17] , [18] ].…”

Section: Discussionmentioning

confidence: 99%

“…The proBNP levels were higher in patients with heart disease compared with the healthy population [ 16 ]. However, on examining the published studies on this topic, the proBNP levels were generally lower than 1000 ng/L in patients with heart failure with left-to-right shunt [ [16] , [17] , [18] ]. In this study, although 80% of the patients diagnosed with MIS-C had heart disease, the mean value for proBNP was approximately eight times higher (8500 ng/dL) than that reported in previous studies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive value of cardiac markers in the prognosis of COVID-19 in children

Güllü

Güngör

İpek

et al. 2021

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

Background and aim Occasionally, children with COVID-19 may develop arrhythmia, myocarditis, and cardiogenic shock involving multisystemic inflammatory syndrome in children (MIS-C). This study aimed to identify the laboratory parameters that may predict early cardiovascular involvement in these patients. Materials and methods Data of 320 pediatric patients, aged 0–18 years (average age, 10.46 ± 5.77 years; 156 female), with positive COVID-19 reverse transcription–polymerase chain reaction test and with cardiac biomarkers at the time of admission to the pediatric emergency department were retrospectively scanned. The age, sex, COVID-19-associated symptoms, pro-brain natriuretic peptide (proBNP), CK-MB, and troponin I levels of the patients were recorded. Results Fever was noted in 58.1% of the patients, cough in 29.7%, diarrhea in 7.8%, headache in 14.7%, sore throat in 17.8%, weakness in 17.8%, abdominal pain in 5%, loss of taste in 4.1%, loss of smell in 5.3%, nausea in 3.4%, vomiting in 3.8%, nasal discharge in 4.4%, muscle pain in 5%, and loss of appetite in 3.1%. The proBNP value ≥282 ng/L predicted the development of MIS-C with 100% sensitivity and 93% specificity [AUC: 0.985 (0.959–1), P < 0.001]; CK-MB value ≥2.95 with 80% sensitivity and 77.6% specificity [AUC: 0.792 (0.581–1), P = 0.026]; and troponin I value ≥0.03 with 60% sensitivity and 99.2% specificity [AUC: 0.794 (0.524–1)]. Conclusions Cardiac markers (proBNP and troponin I), especially proBNP, could be used to detect early diagnosis of cardiac involvement and/or MIS-C in pediatric patients with COVID-19 and to predict related morbidity and mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Predictive value of cardiac markers in the prognosis of COVID-19 in children

Güllü

Güngör

İpek

et al. 2021

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…is is much lower than previous studies [5,16,18]. However, since we calculated the sample size for categorical analysis, Another novel observation in this study was the value of postloading SMII as an inotropic index in discriminating fluid responders among shock subjects.…”

Section: Discussionmentioning

confidence: 64%

Serum NT-Pro-BNP versus Noninvasive Bedside Inotropic Index in Paediatric Shock: A Contest of Myocardial Performance in Response to Fluid Loading

Pudjiadi

Rahayu²,

Wijaya

et al. 2021

Critical Care Research and Practice

View full text Add to dashboard Cite

Background. Mild elevation of serum amino-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is associated with myocardial dysfunction. A significantly lower Smith–Madigan inotropic index (SMII) has been shown to accurately represent cardiac contractility among heart failure subjects. We aim to monitor the effect of fluid resuscitation on cardiac function among paediatric patients by measuring serum NT-pro-BNP and SMII. Methods. This is an observational study on 70 paediatric shock patients. NT-pro-BNP and noninvasive bedside haemodynamic monitoring were done by using an ultrasonic cardiac output monitor (USCOM, USCOM, Sydney, Australia). The presence of cardiac diseases was excluded. SMII was obtained from the USCOM. An increase in the stroke volume index (SVI) of ≥15% indicates fluid responders. Measurements were taken before and after fluid loading. Results. Preloading NT-pro-BNP and SMII category were significantly different between the fluid responsiveness group, p = 0.001 and p = 0.004 , respectively. Higher median NT-pro-BNP (preloading NT-pro-BNP of 1175.00 (254.50–9965.00) ng/mL vs. 196.00 (65.00–509.00) ng/mL, p = 0.002 ) was associated with fluid nonresponders (subjects >12 months old). Preloading NT-pro-BNP <242.5 ng/mL was associated with fluid responders (AUC: 0.768 (0.615–0.921), p = 0.003 ), 82.1% sensitivity, and 68.7% specificity for subjects >12 years old. Delta NT-pro-BNP in fluid responders (15.00 (−16.00–950.00) ng/mL) did not differ from fluid nonresponders (505.00 (−797.00–1600.00) ng/mL), p = 0.456 . Postloading SMII >1.25 W·m−2 was associated with fluid responders (AUC: 0.683 (0.553–0.813), p = 0.011), 61.9% sensitivity, and 66.7% specificity, but not preloading SMII. Fluid responders had a higher mean postloading SMII compared to nonresponders (1.36 ± 0.38 vs. 1.10 ± 0.34, p = 0.006 ). Conclusion. Higher NT-pro-BNP and lower SMII in the absence of cardiac diseases were associated with poor response to fluid loading. The SMII is affected by low preload conditions.

show abstract

“…BNP, NT pro-BNP and Atrial Natriuretic peptide (ANP) are used as cardiac markers for the diagnosis of cardiac failure and to differentiate dyspnoea due to cardiac failure or due to pulmonary or non-cardiac disease 1-3 . This has also been studied in pediatric patients and it has been seen that children with severe heart failure had the highest mean plasma NT pro-BNP, compared to the patients with moderate or mild heart failure 4 . A new role of the natriuretic peptides (NPs) have been found in pulmonary medicine especially pneumonia in which NP levels are seen to be elevated in the grey zone between normal and highly elevated values seen in cardiac failure 1 .…”

Section: Introductionmentioning

confidence: 99%

N-Terminal Pro-B-Type Natriuretic Peptides in Infants and Children With Non-Cardiac Diseases

Ali

Alam

Naureen

2021

PAFMJ

View full text Add to dashboard Cite

Objective: To evaluate the levels of N-terminal pro-B-type Natriuretic Peptide in infants and children with non-cardiac diseases especially respiratory diseases. Study Design: Cross-sectional study. Place and Duration of Study: Department of Chemical Pathology/Biochemistry Laboratory Services of Liaquat National Hospital Karachi Pakistan, from Dec 2018 to Nov 2019. Methodology: Infants and children admitted to the Pediatric department with non-cardiac diseases were included in the study. Non-probability consecutive sampling was done. Blood was taken and analyzed for N- terminal pro-B-type Natriuretic Peptide, Troponin I, urea, creatinine, Lactate dehydrogenase, Creatinine Kinase, lactate and sodium analysis. Results: Out of the 93 patients, 74 (80%) were diagnosed with respiratory disorders, with bronchopneumonia making up 54 (59%) Bronchiolitis 15 (17%) and 4% had miscellaneous respiratory diseases. Out of the remaining 20%, 8 (9%) patients were diagnosed with sepsis, and the remaining 11% were diagnosed with miscellaneous diseases. There was a positive correlation of N- terminal pro-B-type Natriuretic Peptide with Troponin I, urea, creatinine, Creatinine Kinase and Lactate dehydrogenase levels (p<0.05). Conclusion: N- terminal pro-B-type Natriuretic Peptide levels were found to be raised in pediatric patients with non-cardiac diseases especially broncho-pneumonia and in future it may be used as a marker of bronchopneumonia in children.

show abstract

Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure

Cited by 6 publications

References 24 publications

Predictive value of cardiac markers in the prognosis of COVID-19 in children

Predictive value of cardiac markers in the prognosis of COVID-19 in children

Serum NT-Pro-BNP versus Noninvasive Bedside Inotropic Index in Paediatric Shock: A Contest of Myocardial Performance in Response to Fluid Loading

N-Terminal Pro-B-Type Natriuretic Peptides in Infants and Children With Non-Cardiac Diseases

Contact Info

Product

Resources

About