Usefulness of an Alcohol Solution of N-Duopropenide for the Surgical Antisepsis of the Hands Compared with Handwashing with Iodine–Povidone and Chlorhexidine: Clinical Essay

Herruzo-Cabrera, R.; Vizcaino-Alcaide, M.J.; Fdez-Aciñero, M.J.

doi:10.1006/jsre.2000.5931

Cited by 45 publications

(32 citation statements)

References 9 publications

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“…137,284,375 In studies where bacterial counts were obtained after individuals wore gloves for 1-4 hours after washing, however, iodophors demonstrated poor persistent activity. 48,271,282,360,[376][377][378][379][380][381] The in vivo antimicrobial activity of iodophors is significantly reduced in the presence of organic substances such as blood or sputum. 204 Povidone iodine has been found to be less effective than alcohol 60% (v/v) and hydrogen peroxide 3% and 5% on S. epidermidis biofilms.…”

Section: Iodine and Iodophorsmentioning

confidence: 99%

“…chlorhexidine gluconate or quaternary ammonium compounds) limiting regrowth of bacteria on the gloved hand, 377,529,[558][559][560][561] The antimicrobial efficacy of alcoholbased formulations is superior to that of all other currently available methods of preoperative surgical hand preparation. Numerous studies have demonstrated that formulations containing 60-95% alcohol alone, or 50-95% when combined with small amounts of a QAC, hexachlorophene or chlorhexidine gluconate, reduce bacterial counts on the skin immediately post-scrub more effectively than do other agents.…”

Section: Surgical Hand Preparation With Alcohol-based Handrubsmentioning

confidence: 99%

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Hand Hygiene

Longtin¹,

Sax²,

Allegranzi³

et al. 2011

N Engl J Med

108

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Section: Iodine and Iodophorsmentioning

confidence: 99%

Section: Surgical Hand Preparation With Alcohol-based Handrubsmentioning

confidence: 99%

Hand Hygiene

Longtin¹,

Sax²,

Allegranzi³

et al. 2011

N Engl J Med

108

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“…The relation between sustained improvement in hand hygiene compliance, facilitated by the routine use of hand rubs, and reduced nosocomial infection rates has been evidenced [2][3][4][5]. Therefore, the volume of hand rubs used (from 15 to 20 liters) per 1000 days following the admission in hospital has been one of the current indicators to evaluate hospital performances.…”

Section: Introductionmentioning

confidence: 99%

Current and New Strategies for the Delivery of Antiseptic Agents

Constant¹,

Falson²,

Pirot³

2006

CDD

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The present mini-review explores the current methods used for the delivery of antiseptics and topical antimicrobials. Relevance of hand scrub with antiseptic liquid soap (e.g. chlorhexidine, PVP-iodine, triclosan) and alcohol-based hand rub is discussed and compared in terms of bactericidal activity, skin tolerance, and medical staff observance. New strategies for antibacterial delivery focus on the challenge of colloidal drug carrier such as liposomes, micro- and nanoparticles enabling sustained bactericidal effect and effective bacterial targeting.

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“…[1][2][3][4] Currently, among the wide range of alcohol-based solutions, n-propanol is the reference alcohol due to its superior efficacy when compared with ethanol and isopropanol. 2 Additionally, the efficacy tests performed with these alcohol-based solutions demonstrated that they maintain a residual effect on hand microbiota of volunteers for some time after application (eg, 3 hours used in EN 12791, a test for surgical antisepsis 5 ).…”

mentioning

confidence: 99%