Usefulness of anti-GQ1b IgG antibody testing in Fisher syndrome compared with cerebrospinal fluid examination

Nishimoto, Yukihiro; Odaka, Masaaki; Hirata, Koichi; Yuki, Nobuhiro

doi:10.1016/j.jneuroim.2003.11.017

Cited by 129 publications

(89 citation statements)

References 19 publications

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“…Typical CSF findings are elevated protein levels with normal WBC counts, which are present in over 75% of patients [13]. These changes were also presented by our patient.…”

Section: Case Reportsupporting

confidence: 79%

Gullian- Barre Syndrome in Pregnancy – A Case Report and Review of the Literature

Zilberlicht¹,

Yonai²

2016

Gynecol Obstet

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The immune-mediated Gullian-Barré syndrome (GBS) is an acute demyelinating polyradiculopathy (AIDP) which typically presents as progressive, fairly symmetric muscle weakness accompanied by absent or depressed deep tendon reflexes. It has been linked to various infectious agents, such as Campilobacter jejuni and typically presents 2-4 weeks following a respiratory or gastrointestinal illness. With an estimated incidence in the general population of 0.75-2:100,000, its occurrence in pregnancy does not differ. Diagnostic criteria consist of clinical, laboratory and electrophysiological tests. Treatment of pregnant and non-pregnant patients with GBS usually does not differ and it is mainly composed of supportive care and monitoring of respiratory, cardiac and hemodynamic functions. Disease modifying treatments such as plasmapheresis and intravenous immunoglobulin (IVIG) are relatively safe in pregnancy. Timing and mode of delivery are based on obstetric indications and depend on maternal and fetal status. As such, if a pre-term delivery is indicated a course of antenatal corticosteroids should be considered. Therefore, GBS in pregnancy should be handled by a multidisciplinary team involving neurologists, obstetricians and anesthesiologists.We present a case report of an otherwise healthy woman diagnosed with GBS in pregnancy. Patient presentation, diagnosis, treatment and outcome as well of review of the literature will be discussed.

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“…Typical CSF findings are elevated protein levels with normal WBC counts, which are present in over 75% of patients [13]. These changes were also presented by our patient.…”

Section: Case Reportsupporting

confidence: 79%

Gullian- Barre Syndrome in Pregnancy – A Case Report and Review of the Literature

Zilberlicht¹,

Yonai²

2016

Gynecol Obstet

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“…CSF protein is known to be elevated in many neurological and nonneurological diseases such as myxedema and uremia [5,6,7,8,9,10,11,12]. Three mechanisms can elevate the protein levels in the CSF: increased permeability to protein by impairment of the blood-CSF barrier [5, 7, 8, 13], reduced CSF flow or decreased CSF absorption [5, 7] and Ig production in the CNS, as represented by isoelectric focusing of oligoclonal IgG band or increased IgG index [5, 7, 14].…”

Section: Discussionmentioning

confidence: 99%

Elevation of Cerebrospinal Fluid Protein in Patients with Diabetes Mellitus Is Associated with Duration of Diabetes

et al. 2008

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We investigated the relationships between total cerebrospinal fluid (CSF) protein in diabetic patients and the clinical characteristics of diabetes mellitus. The subjects comprised 16 diabetic patients (median age = 60.5 years, range = 47–71) who were studied retrospectively. Patients with diseases known to be associated with increases in total CSF protein were excluded as far as possible. The median total CSF protein and albumin quotient in the diabetic group were 52.5 mg/dl (range = 41–84) and 6.13 × 10^–3 (range = 4.0 × 10^–3 to 13.1 × 10^–3), respectively. These results were significantly higher than those in 28 age-matched nondiabetic patients (median = 59.0 years, range = 50–71) (p < 0.01). Duration of diabetes was associated with total CSF protein (r = 0.642, p < 0.01). If the CSF shows increased total protein in a diabetic patient who has not suffered from long-term diabetes (≧5 years), causes other than diabetes should be considered to explain increases in total CSF protein. We need to confirm the present results by studying a larger population of diabetic patients.

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“…The CSF finding of a slightly raised protein with normal cell count was suggestive, although CSF can often be normal in the first weeks of disease. 2 Serum anti-GQ1B antibodies were positive, as is typical, 3 although this test took weeks to return and was therefore not helpful in the acute setting. Viral serology was positive for cytomegalovirus IgM, suggesting recent infection and the cause of the preceding flu-like illness.…”

Section: Discussionmentioning

confidence: 95%

A case of collapse

2013

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-We describe the case of a woman who presented with seemingly non-specific symptoms, including collapse, but through examination was eventually revealed to have an unusual, potentially fatal, but treatable neurological condition. We share some thoughts on the process of diagnosis, the difficulty of diagnosing a rare disease and the practice of neurology on the acute medical take. We also highlight the value of screening neurological examination in acute medical patients.

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Usefulness of anti-GQ1b IgG antibody testing in Fisher syndrome compared with cerebrospinal fluid examination

Cited by 129 publications

References 19 publications

Gullian- Barre Syndrome in Pregnancy – A Case Report and Review of the Literature

Gullian- Barre Syndrome in Pregnancy – A Case Report and Review of the Literature

Elevation of Cerebrospinal Fluid Protein in Patients with Diabetes Mellitus Is Associated with Duration of Diabetes

A case of collapse

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