Usefulness of Atrial Deformation Analysis to Predict Left Atrial Fibrosis and Endocardial Thickness in Patients Undergoing Mitral Valve Operations for Severe Mitral Regurgitation Secondary to Mitral Valve Prolapse

Cameli, Matteo; Lisi, Matteo; Righini, Francesca Maria; Massoni, Alberto; Natali, Benedetta Maria; Focardi, Marta; Tacchini, Damiana; Geyer, Alessia; Curci, Valeria; Tommaso, Cristina Di; Lisi, Gianfranco; Maccherini, Massimo; Chiavarelli, Mario; Massetti, Massimo; Tanganelli, Piero; Mondillo, Sergio

doi:10.1016/j.amjcard.2012.10.049

Cited by 239 publications

(182 citation statements)

References 25 publications

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“…In addition, a negative correlation was found between the above‐mentioned STE‐derived variables and conventional echocardiographic measurements of left cardiac chamber size. These data are in agreement with previous reports focused on conventional echocardiographic assessment of LA function in dogs with MMVD,2, 7 as well as human studies in patients investigated by STE,38, 39, 40, 41, 42, 43, 44 and suggest progressive LA dysfunction with worsening of MMVD and LA dilatation. These findings might be explained by the progressive LA volume overload due to MR and remodeling and by an increase in LV filling pressures in the advanced phases of the disease.…”

Section: Discussionsupporting

confidence: 93%

Assessment of Left Atrial Deformation and Function by 2‐Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease

Toaldo

Romito

Guglielmini

et al. 2017

Veterinary Internal Medicne

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BackgroundThe assessment of left atrial (LA) function by 2‐dimensional speckle tracking echocardiography (STE) holds important clinical implications in human medicine. Few similar data are available in dogs.ObjectivesTo assess LA function by STE in dogs with and without myxomatous mitral valve disease (MMVD), analyzing LA areas, systolic function, and strain.AnimalsOne hundred and fifty dogs were divided according to the American College of Veterinary Internal Medicine classification of heart failure: 23 dogs in class A, 52 in class B1, 36 in class B2, and 39 in class C + D.MethodsProspective observational study. Conventional morphologic and Doppler variables, LA areas, and STE‐based LA strain analysis were performed in all dogs and results were compared among groups. Correlation analysis was carried out between LA STE variables and other echocardiographic variables.ResultsVariability study showed good reproducibility for all the tested variables (coefficient of variation <16%). Left atrial areas, fractional area change, peak atrial longitudinal strain (PALS), peak atrial contraction strain, and contraction strain index (CSI) differed significantly between groups B2 and C + D and all the other groups (overall P < .001), whereas only PALS differed between groups B1 and A (P = .01). Left atrial areas increased with progression of the disease, whereas LA functional parameters decreased. Only CSI increased nonsignificantly from group A to group B1 and then progressively decreased. Thirty‐one significant correlations (P < .001, r > .3) were found between conventional left heart echocardiographic variables and LA areas and strain variables.Conclusions and Clinical ImportanceLeft atrial STE analysis provides useful information on atrial function in the dog, highlighting a progressive decline in atrial function with worsening of MMVD.

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Section: Discussionsupporting

confidence: 93%

Assessment of Left Atrial Deformation and Function by 2‐Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease

Toaldo

Romito

Guglielmini

et al. 2017

Veterinary Internal Medicne

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“…The LA strain reflects LA reservoir, conduit and booster pump function. Furthermore, it correlates with the extent of LA fibrosis, especially in patients with persistent AF [7,33].…”

Section: Left Atrial Strainmentioning

confidence: 99%

“…Dilatation of the LA is an independent predictor of new onset AF [4]. It is also a wellknown predictor of low success for CA in terms of AF recurrence [5][6][7].…”

Section: Atrial Sizementioning

confidence: 99%

Echocardiographic predictors of atrial fibrillation recurrence after catheter ablation: A literature review

et al. 2020

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“…16 Tissue Doppler and speckle tracking also allows for evaluation of LA tissue deformation (strain) and rate of deformation (strain rate) at different points, providing estimate of LA systolic (at end ventricular diastole) and diastolic (at ventricular systole) properties. 17 …”

Section: -13mentioning

confidence: 99%

Left Atrium in Heart Failure With Preserved Ejection Fraction

Rossi

Gheorghiade

Triposkiadis

et al. 2014

Circ: Heart Failure

124

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LA is crucial for the volume receptor reflex through its mechanoreceptors located in the venous-atrial junctions. 6 An optimal volume control is essential for cardiovascular function and might be vital in conditions like hemorrhages and HF. This system is regulated on a moment-by-moment basis and works in parallel with other endocrine systems, such as natriuretic peptide, and angiotensin-aldosterone signals for more long-term regulation. The atrial mechanoreceptors are highly efficient, and fluctuation in venous volume of <1% can be signaled to the brain through autonomic nerves. 7 The LA (Circ Heart Fail.

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Usefulness of Atrial Deformation Analysis to Predict Left Atrial Fibrosis and Endocardial Thickness in Patients Undergoing Mitral Valve Operations for Severe Mitral Regurgitation Secondary to Mitral Valve Prolapse

Cited by 239 publications

References 25 publications

Assessment of Left Atrial Deformation and Function by 2‐Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease

Assessment of Left Atrial Deformation and Function by 2‐Dimensional Speckle Tracking Echocardiography in Healthy Dogs and Dogs With Myxomatous Mitral Valve Disease

Echocardiographic predictors of atrial fibrillation recurrence after catheter ablation: A literature review

Left Atrium in Heart Failure With Preserved Ejection Fraction

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