Usefulness of C-reactive protein, serum amyloid A component, and haptoglobin determinations in bitches with pyometra for monitoring early post-ovariohysterectomy complications

Factors Influencing Serum Amyloid Type A (Saa) Concentrations in Horses

“…These proteins are diagnostically useful tools to study several diseases, such as endometritis, in mares [42,43] and bitches [44] and mammary tumor disorders [45], among others. Specifically in the mare, in the authors' knowledge, the scientific literatures is very scarce and fragmentary, and have focused primarily on the peripartum period [15,36], estrous cycle [25] and pregnancy [26,27].…”

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

“…In pyometra (Figure 3), CRP, SAA and haptoglobin were valid indicators of the infl ammatory state of the uterus and systemic infl ammation mainly caused by E. coli endotoxins, making it possible to differentiate between open and closed cervix infections and to evaluate the severity of the infl ammatory process especially with post-surgical complications [10,29,30]. A recent study demonstrated the clinical value of SAA determination in bitches with signifi cant differences between septic (130.8 mg/L) and non-septic pyometra (88.5 mg/L) while CRP values did not show signifi cant differences between both groups.…”

“…Additionally, CRP concentration in combination with Figure 3. Overview of C-reactive protein, haptoglobin and serum amyloid A concentrations in pyometra in bitches [3,10,29,30,32,34] the percentage of band neutrophils was useful to differentiate between pyometra and cystic endometrial hyperplasia. CRP showed 97.7% sensitivity and 75% specifi city in predicting the presence of pyometra [34].…”

“…Recently, this protein has been investigated as a signifi cant prognostic marker and as a useful predictive indicator of prognosis in various diseases [7][8][9][10]. An isoform of SAA (SAA-2) is involved in reactive amyloidosis and other chronic infl ammatory diseases.…”

<b>Caracterização da anemia em cadelas com piometra</b>

“…Quando destruída, ela libera uma endotoxina que é rica em lipopolissacarídeo (LPS), quimicamente estável e biologicamente ativa, causando lesão endometrial e sintomatologia clínica. Embora a infecção bacteriana não seja o fator desencadeante da piometra, ela é a responsável pela maioria dos casos de morbidade e mortalidade (RIETSCHEL et al, 1983;DABROWSKI et al, 2009). …”