Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease

Nezu, Tomohisa; Hosomi, Naohisa

doi:10.5551/jat.rv17044

Cited by 40 publications

(28 citation statements)

References 120 publications

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“…These findings may suggest that ICA-IMT, especially the max ICA-IMT, is an appropriate screening point for CVD risk stratification. 35 In our results, at the 24-month follow up, sitagliptin treatment significantly improved the progression of mean and max ICA-IMT in hyperuricemia subgroup compared with conventional treatment. This suggests that patients with T2DM and hyperuricemia could benefit from sitagliptin treatment.…”

Section: Discussionsupporting

confidence: 52%

Sitagliptin on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients: a subgroup analysis of the PROLOGUE study

Zhao

Wang

et al. 2021

Therapeutic Advances in Chronic Disease

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Background and Aims: Studies have shown that dipeptidyl peptidase-4 (DDP-4) inhibitors have anti-atherosclerotic effects. However, in the PROLOGUE study, sitagliptin failed to slow the progression of carotid intima-media thickness (CIMT) relative to conventional therapy. We conducted a post hoc analysis of the PROLOGUE study and compared the effects of sitagliptin and conventional therapy on changes in CIMT in subgroups with or without hyperuricemia. Methods: The PROLOGUE study was a randomized controlled trial of 442 patients with type 2 diabetes mellitus (T2DM). Patients were randomized to receive sitagliptin added therapy or conventional therapy. Based on the serum uric acid levels of all study populations in the PROLOGUE study, we divided them into hyperuricemia subgroup ( n = 104) and non-hyperuricemia subgroup ( n = 331). The primary outcome was changed in carotid intima-media thickness (CIMT) parameters compared with baseline during the 24 months treatment period. Results: In the hyperuricemia subgroup, compared with the conventional therapy group, the changes in the mean internal carotid artery (ICA)-IMT and max ICA-IMT at 24 months were significantly lower in the sitagliptin group [−0.233 mm, 95% confidence interval (CI) (−0.419 to 0.046), p = 0.015 and −0.325 mm, 95% CI (−0.583 to −0.068), p = 0.014], although there was no significant difference in the common carotid artery CIMT. Conclusion: The results of our analysis indicated that sitagliptin attenuated the progression of CIMT than conventional therapy in T2DM and hyperuricemia patients.

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Section: Discussionsupporting

confidence: 52%

Sitagliptin on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients: a subgroup analysis of the PROLOGUE study

Zhao

Wang

et al. 2021

Therapeutic Advances in Chronic Disease

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“…Наличие гипоэхогенных АСБ в сонных артериях является независимым предиктором развития неблагоприятных сердечно-сосудистых событий, в том числе инсульта. Более того, прогрессивное снижение эхогенности АСБ при динамическом наблюдении позволяет получить дополнительную прогностическую информацию и идентифицировать пациентов, имеющих максимальный риск развития кардиоваскулярных катастроф [15].…”

Section: Discussionunclassified

Factors associated with atherosclerotic plaque echogenicity in patients aged 40-64 with carotid atherosclerosis

et al. 2021

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Aim To identify clinical and laboratory indexes related with the atherosclerotic plaque (ASP) echogenicity based on results of the analysis of grey-scale median (GSM) in patients aged 40–64 years.Material and methods The study included patients aged 40–64 years with carotid atherosclerosis. The carotid duplex scanning was performed for all patients. The GSM analysis of obtained images was performed with the Adobe Photoshop CS6 software.Results Atherosclerotic cardiovascular diseases were found in 31 (21.4 %) patients. Correlation analysis determined inverse interrelationships between GSM and the body weight index (BWI) (r=–0.359; p<0.0001), waist circumference (r=–0.357; p<0.0001), and levels of uric acid (r=–0.244; p=0.021) and glucose (r=–0.205; p=0.032). According to the regression, statistically significant correlations remained between GSM and BWI as well as the waist circumference after the adjustment for sex and age.Conclusion In patients with carotid atherosclerosis aged 40–64 years, the decrease in ASP GSM was associated with increases in BWI and waist circumference.

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“…Ultrasound is a non-invasive and economical diagnostic technique that helps provide valuable information on carotid atherosclerosis such as carotid intima thickness (CIMT) and carotid plaque presence (Park, 2016). Several studies suggest that carotid plaque is more powerful in predicting vascular outcomes, compared with CIMT (Ho, 2016;Nezu and Hosomi, 2020).…”

Section: Introductionmentioning

confidence: 99%

Vulnerable Plaque Is More Prevalent in Male Individuals at High Risk of Stroke: A Propensity Score-Matched Study

Gao

Zhang

et al. 2021

Front. Physiol.

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ObjectivesTo assess the gender differences in the prevalence of carotid vulnerable plaques in high-risk individuals for stroke in a multicenter, cross-sectional study.MethodsIn the year 2015, 18595 residents who were at the age of 40 or older participated in a face-to-face study in eight communities in southwestern China. Totally 2,644 participants at high risk of stroke were enrolled. Before and after propensity score matching (PSM), the prevalence of carotid plaques and vulnerable plaques were compared between men and women. Multivariate analyses were applied to explore the association between the gender and carotid plaques. Stratified analyses and interaction tests were performed to identify factors that might modify the association between the gender and carotid plaques.ResultsAmong 2644 high-risk individuals enrolled, there were 1,202 (45.5%) men and 1442 (54.5%) women. Carotid plaques were detected in 904 (34.2%) participants, while vulnerable plaques were found in 425 (16.1%) participants. Before PSM, carotid plaques were more prevalent in male individuals than the female (36.7% vs. 32.1%, p = 0.01), as well as vulnerable plaque (20.0% vs. 12.8%, p < 0.01). Men tend to have a higher prevalence of vulnerable plaques in multivariate analyses (adjusted OR 1.70, 95% CI 1.10–2.62, p = 0.02). Stratified analyses and interaction tests demonstrated that the association between male sex and vulnerable carotid plaque did not change by age, family history of stroke, histories of chronic disease, smoking status, drinking status, physical activity, and BMI (all p for interaction > 0.05). After PSM, vulnerable plaques were still more prevalent in male individuals than the female (17.03% vs. 12.07%, p = 0.032).ConclusionMale individuals had a higher risk of vulnerable carotid plaque independent of classical vascular risk factors. Whether there is a gender-specific association between variations in genes related to inflammation, lipid metabolis, and endothelial function and plaque vulnerability needs to be further studied.

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Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease

Cited by 40 publications

References 120 publications

Sitagliptin on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients: a subgroup analysis of the PROLOGUE study

Sitagliptin on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients: a subgroup analysis of the PROLOGUE study

Factors associated with atherosclerotic plaque echogenicity in patients aged 40-64 with carotid atherosclerosis

Vulnerable Plaque Is More Prevalent in Male Individuals at High Risk of Stroke: A Propensity Score-Matched Study

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