Usefulness of circulating interleukin-18 concentration in acute myocardial infarction as a risk factor for late restenosis after emergency coronary angioplasty

Kawasaki, Daizo; Tsujino, Takeshi; Morimoto, Shinji; Fujioka, Yoshio; Naito, Yoshiro; Okumura, Takahiro; Masutani, Motomaru; Shimizu, Hiroki; Yuba, Masao; Ueda, Atsunori; Ohyanagi, Mitsumasa; Kashiwamura, Shin-ichiro; Okamura, Haruki; Iwasaki, Tadaaki

doi:10.1016/s0002-9149(03)00279-0

Cited by 21 publications

(17 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study in patients with a previous MI, IL-18 was significantly associated with coronary plaque area, and the risk of restenosis was increased in patients with elevated IL-18 levels after percutaneous coronary intervention for acute MI. 5,22 These findings support the theory that IL-18 is a cytokine with particular involvement in atherosclerotic plaque progression and instability. Further support for this theory is the finding of a much higher expression of IL-18 in human atherosclerotic plaques than in normal arteries 6 and the finding that the overexpression of IL-18 in apolipoprotein E-deficient mice increases vulnerability to plaque rupture, as judged from plaque morphology.…”

Section: Discussionsupporting

confidence: 72%

Interleukin-18 as a Predictor of Future Events in Patients With Acute Coronary Syndromes

Hartford

Wiklund

Hultén

et al. 2010

ATVB

View full text Add to dashboard Cite

Objective-The aim of this study was to assess the short-and long-term prognostic significance of levels in patients with acute coronary syndromes (ACS). Methods and Results-In patients hospitalized with ACS (median age, 66 years; 30% females), we evaluated associations of serum IL-18 levels from day 1 (nϭ1261) with the short-(Ͻ3 months) and long-term (median, 7.6 years) risk of death, development of congestive heart failure (CHF), and myocardial infarction (MI). IL-18 was not significantly associated with short-term mortality. In the long term, IL-18 levels were significantly related to all-cause mortality, even after adjustment for clinical confounders (hazard ratio [HR], 1.19; 95% confidence interval, 1.07 to 1.33; Pϭ0.002). Long-term, cardiovascular mortality was univariately related to IL-18, and the adjusted relation between noncardiovascular mortality and IL-18 was highly significant (HR, 1.36; 95% confidence interval, 1.11 to 1.67; Pϭ0.003). IL-18 independently predicted CHF, MI, and cardiovascular death/CHF/MI in both the short and long term. Measurements from day 1 of ACS and 3 months after ACS had a similar power to predict late outcome. Conclusion-The addition of the measurement of IL-18 to clinical variables improved the prediction of risk of all-cause and noncardiovascular mortality. The association between IL-18 and noncardiovascular mortality is intriguing and warrants further study.

show abstract

Section: Discussionsupporting

confidence: 72%

Interleukin-18 as a Predictor of Future Events in Patients With Acute Coronary Syndromes

Hartford

Wiklund

Hultén

et al. 2010

ATVB

View full text Add to dashboard Cite

show abstract

“…4,21 Genetic correlations between IL-1 genotype and the risk of restenosis after percutaneous coronary intervention have been reported. 22 Moreover, recent studies have shown a strong correlation between higher IL-18 plasma levels and restenosis after percutaneous coronary intervention 23 or clinical outcome in patients with coronary artery disease. 24 Experimental animal models of other vascular injuries also demonstrated the critical role of IL-1␤ and IL-18 in neointimal formation.…”

Section: Discussionmentioning

confidence: 99%

Critical Role of Bone Marrow Apoptosis-Associated Speck-Like Protein, an Inflammasome Adaptor Molecule, in Neointimal Formation After Vascular Injury in Mice

et al. 2008

View full text Add to dashboard Cite

Background-Inflammatory cytokines such as interleukin (IL)-1␤ and IL-18 play an important role in the development of atherosclerosis and restenosis. Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates caspase-1-dependent IL-1␤ and IL-18 generation; however, the role of ASC in vascular injury remains undefined. Here, we investigated the contribution of ASC to neointimal formation after vascular injury in ASC-deficient (ASC Ϫ/Ϫ ) mice. Methods and Results-Wire-mediated vascular injury was produced in the femoral artery of ASC Ϫ/Ϫ and wild-type mice. Immunohistochemical analysis revealed that ASC was markedly expressed at the site of vascular injury. Neointimal formation was significantly attenuated in ASC Ϫ/Ϫ mice after injury. IL-1␤ and IL-18 were expressed in the neointimal lesion in wild-type mice but showed decreased expression in the lesion of ASC Ϫ/Ϫ mice. To investigate the contribution of bone marrow-derived cells, we developed bone marrow-transplanted mice and found that neointimal formation was significantly decreased in wild-type mice in which bone marrow was replaced with ASC Ϫ/Ϫ bone marrow cells. Furthermore, in vitro experiments showed that the proliferation activity of ASC Ϫ/Ϫ vascular smooth muscle cells was not impaired. Conclusions-These findings suggest that bone marrow-derived ASC is critical for neointimal formation after vascular injury and identify ASC as a novel therapeutic target for atherosclerosis and restenosis. (Circulation. 2008;117: 3079-3087.)

show abstract

“…2 Increased serum levels of IL-18 in animals subjected to vascular injury are in keeping with an active role for this cytokine in the tissue pathogenesis and correlate well with epidemiological evidence showing higher IL-18 plasma levels associated with human restenosis. 16,23 To elucidate clearly the precise contribution of IL-18 involvement in the development of vascular damage after balloon angioplasty, we examined the effect of IL-18 neutralization on neointimal formation. Animals treated with neutralizing IL-18 IgG exhibited a significant reduction in neointimal size, showing diminished neointimal content of ␣-SMA-positive cells.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, Yamagami et al 15 demonstrated an association between higher serum IL-18 levels and greater carotid intima-media thickness in patients without histories of cardiovascular accidents. Moreover, Kawasaki et al 16 showed that higher IL-18 plasma levels were associated with restenosis after emergency coronary angioplasty performed in patients with acute myocardial infarction.…”

Section: Clinical Perspective P 437mentioning

confidence: 99%

Neutralization of Interleukin-18 Inhibits Neointimal Formation in a Rat Model of Vascular Injury

et al. 2006

View full text Add to dashboard Cite

Background-Studies in humans and animal models suggest that interleukin-18 (IL-18) plays a crucial role in vascular pathologies. IL-18 is a predictor of cardiovascular death in angina and is involved in atherotic plaque destabilization. Higher IL-18 plasma levels also are associated with restenosis after coronary artery angioplasty performed in patients with acute myocardial infarction. We investigated the effective role of IL-18 in neointimal formation in a balloon-induced rat model of vascular injury. Methods and Results-Endothelial denudation of the left carotid artery was performed by use of a balloon embolectomy catheter. Increased expression of IL-18 and IL-18R␣/␤ mRNA was detectable in carotid arteries from days 2 to 14 after angioplasty. The active form of IL-18 was highly expressed in injured arteries. Strong immunoreactivity for IL-18 was detected in the medial smooth muscle cells at days 2 and 7 after balloon injury and in proliferating/migrating smooth muscle cells in neointima at day 14. Moreover, serum concentrations of IL-18 were significantly higher among rats subjected to vascular injury. Treatment with neutralizing rabbit anti-rat IL-18 immunoglobulin G significantly reduced neointimal formation (by 27%; PϽ0.01), reduced the number of proliferating cells, and inhibited interferon-␥, IL-6, and IL-8 mRNA expression and nuclear factor-B activation in injured arteries. In addition, in vitro data show that IL-18 affects smooth muscle cell proliferation. Conclusions-These

show abstract

Usefulness of circulating interleukin-18 concentration in acute myocardial infarction as a risk factor for late restenosis after emergency coronary angioplasty

Cited by 21 publications

References 11 publications

Interleukin-18 as a Predictor of Future Events in Patients With Acute Coronary Syndromes

Interleukin-18 as a Predictor of Future Events in Patients With Acute Coronary Syndromes

Critical Role of Bone Marrow Apoptosis-Associated Speck-Like Protein, an Inflammasome Adaptor Molecule, in Neointimal Formation After Vascular Injury in Mice

Neutralization of Interleukin-18 Inhibits Neointimal Formation in a Rat Model of Vascular Injury

Contact Info

Product

Resources

About