Usefulness of Ct value in acute respiratory infections caused by respiratory syncytial virus A and B and influenza virus A (H1N1)pdm09, A (H3N2) and B

Reina, Jordi; Morales, Carmen; Busquets, María Bertely; Norte, Cristina

doi:10.1016/j.eimce.2018.04.004

Cited by 10 publications

(11 citation statements)

References 13 publications

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“…Depending on the area, there may even be a lack of beds for patients who require intensive care in Japan. A previous report documented that Ct-value of influenza virus and RS virus was effective to evaluate the disease severity [6]. The result suggests that Ct-values decrease as patients recover while some of them remain positive (Table 2).…”

mentioning

confidence: 86%

Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?

Asai

Sakanashi

Ohashi

et al. 2021

Journal of Infection and Chemotherapy

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The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of rRT-PCR assay could remain positive among asymptomatic patients for longer than 2 weeks. The discharge criteria of COVID-19 patients using a negative result of rRT-PCR should be reconsidered.

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mentioning

confidence: 86%

Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?

Asai

Sakanashi

Ohashi

et al. 2021

Journal of Infection and Chemotherapy

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“…Although the number of cases of influenza A (H1N1) pneumonia has declined, it is still a major public health problem [1,2]. Acute respiratory infections of viral cause are very frequent entities, and in our patient the acute viral respiratory infection was confirmed by RT-PCR, which allowed to detect influenza A (H1N1) [3].…”

Section: Discussionmentioning

confidence: 67%

CT can aid as a tool in the diagnostic in influenza A (H1N1)-associated pneumonia

Cristina¹,

Augusto²,

Solange³

et al. 2019

Int J Case Rep Images

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Introduction: In our study, we present a case of influenza A (H1N1)-associated pneumonia where the computed tomography (CT) findings were of great importance in the suspicion of the etiological agent, later confirmed by reverse transcription polymerase chain reaction (RT-PCR). The CT exam is very fast and allows rapid evaluation of the images, with suspected diagnosis, and institution of the treatment, allowing better clinical

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“…Three studies investigated the association of Ct value with ICU admission, 21,26,27 all of which reported no significant associations. In Reina et al, 26 Ct values were lower for patients in the ICU, but this did not reach statistical significance.…”

Section: Mortality Disease Severity Disease Duration and Icu Admissionmentioning

confidence: 99%

“…Four studies investigated the association of Ct value with hospital admission, all of which showed no significant association between low Ct values and hospitalization. 8,18,26,27 The study by Reina et al 26 reported no significant variation in Ct values between ICU, emergency department (ED) or hospital admission, and Zou et al 27 reported no difference in Ct values between inpatients and outpatients. Conversely, the study by Fuller et al, 18 which provided clearly defined methodology (Table S2), reported higher median Ct values for inpatients (Ct 35.0) than outpatients (Ct 29.8), with increasing Ct values increasing the odds of being an inpatient versus an outpatient.…”

Section: Hospitalization and Length Of Staymentioning

confidence: 99%

Systematic review on the association between respiratory virus real-time PCR cycle threshold values and clinical presentation or outcomes

Bouzid

Vila

Hansen

et al. 2021

Journal of Antimicrobial Chemotherapy

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Objectives It is unclear whether real-time (rt)-PCR cycle threshold (Ct) values can be utilized to guide clinical and infection-control decisions. This systematic review assesses the association between respiratory pathogen rt-PCR Ct values and clinical presentation or outcomes. Methods We searched MEDLINE, EMBASE and Cochrane library databases on 14–17 January 2020 for studies reporting the presence or absence of an association between Ct values and clinical presentation or outcomes, excluding animal studies, reviews, meta-analyses, and non-English language studies. Results Among 33 studies identified (reporting on between 9 and 4918 participants by pathogen), influenza (n = 11 studies; 4918 participants), human rhinovirus (HRV, n = 11; 2012) and respiratory syncytial virus (RSV, n = 8; 3290) were the most-studied pathogens. Low influenza Ct values were associated with mortality in 1/3 studies, with increased disease severity/duration or ICU admission in 3/9, and with increased hospitalization or length of hospital stay (LOS) in 1/6. Low HRV Ct values were associated with increased disease severity/duration or ICU admission in 3/10 studies, and with increased hospitalization or LOS in 1/3. Low RSV Ct values were associated with increased disease severity/duration or ICU admission in 3/6 studies, and with increased hospitalization or LOS in 4/4. Contradictory associations were also identified for other respiratory pathogens. Conclusions Respiratory infection Ct values may inform clinical and infection-control decisions. However, the study heterogeneity observed in this review highlights the need for standardized workflows to utilize Ct values as a proxy of genomic load and confirm their value for respiratory infection management.

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Usefulness of Ct value in acute respiratory infections caused by respiratory syncytial virus A and B and influenza virus A (H1N1)pdm09, A (H3N2) and B

Cited by 10 publications

References 13 publications

Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?

Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?

CT can aid as a tool in the diagnostic in influenza A (H1N1)-associated pneumonia

Systematic review on the association between respiratory virus real-time PCR cycle threshold values and clinical presentation or outcomes

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