Usefulness of Diffusion-Weighted Imaging in the Localization of Prostate Cancer

Diffusion weighted imaging in prostate cancer

“…This has already been demonstrated for MRS [34,35]. Kajihara and colleagues found that the addition of DWI to T2WI increased both sensitivity (from 26-51% to 47-72%) and positive predictive value (from 47-73% to 58-80%) in the localising PC and suggested that this may improve radiation therapy planning [19]. Detection of tumour in areas of haemorrhage following TRUS biopsy is a problem with T2WI.…”

“…Miao et al [16] showed that the sensitivity and specificity rates for T2WI was 76% and 70% respectively, compared with 86% and 80% for DWI. Combined T2WI and DWI yield slightly better results, with reported sensitivity and specificity rates of 45-89% and 61-97% respectively, compared with 74-85% and 57-95% respectively for DWI alone and 25-87% and 57-92% respectively for T2WI alone [12,15,[17][18][19][20][21][22][23][24][25][26].…”

“…This may be attributed to increased contrast on DWI images compared with conventional imaging [46]. When combined with T2-weighted imaging, the sensitivity and specificity for PC range from 71 to 89% and 61 to 91% respectively, compared with 51-86% and 60-84% respectively for T2WI alone [17,19,21,22,47]. Lim et al [24] showed that combined T2WI and DWI imaging increased the AUC among readers from 0.66-0.79 for T2WI alone and 0.74-0.86 for DWI alone, to 0.76-0.9 (p<0.001).…”

“…There is currently no consensus on the optimal b-value to use in prostate DWI [19,29,46]. Most studies have used b-values between 0 and 1,000 sec/mm 2 .…”

Diffusion Weighted Imaging in Prostate Cancer a Review.

“…Most researches and practices have used the b value of 0-1000 sec/mm2. (10,29) There is a need of standardization. However in few investigations of prostate DWI b value greater than1000 sec/mm2 has also been performed.…”