Usefulness of dual‐energy computed tomography for the evaluation of psoriatic arthritis accompanied by knee osteoarthritis

Umezawa, Yoshinori; Yanaba, Koichi; Asahina, Akihiko; Nakagawa, Hidemi; Fukuda, Takeshi; Fukuda, Kunihiko

doi:10.1111/1346-8138.14530

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Genetic factors are critically involved in the development of psoriasis [12,13]. In addition to skin eruption, approximately 30% of patients with psoriasis manifest psoriatic arthritis [14][15][16][17][18][19]. Psoriasis is also significantly comorbid with other autoimmune diseases, such as bullous pemphigoid [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-17A and Keratinocytes in Psoriasis

Furue

Tsuji

et al. 2020

IJMS

190

155

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The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates a crucial pathogenic role of IL-17A in this autoinflammatory skin disease. IL-17A accelerates the proliferation of epidermal keratinocytes. Keratinocytes produce a myriad of antimicrobial peptides and chemokines, such as CXCL1, CXCL2, CXCL8, and CCL20. Antimicrobial peptides enhance skin inflammation. IL-17A is capable of upregulating the production of these chemokines and antimicrobial peptides in keratinocytes. CXCL1, CXCL2, and CXCL8 recruit neutrophils and CCL20 chemoattracts IL-17A-producing CCR6+ immune cells, which further contributes to forming an IL-17A-rich milieu. This feed-forward pathogenic process results in characteristic histopathological features, such as epidermal hyperproliferation, intraepidermal neutrophilic microabscess, and dermal CCR6+ cell infiltration. In this review, we focus on IL-17A and keratinocyte interaction regarding psoriasis pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Interleukin-17A and Keratinocytes in Psoriasis

Furue

Tsuji

et al. 2020

IJMS

190

155

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“…In a case of PsA associated with nail psoriasis, DECT with iodine mapping was able to detect active enthesitis in the nail root where X-ray and dermatoscopy of the hyponychium could not [35]. In another study by Umezawa et al, the use of iodine mapping with DECT uncovered a case of psoriatic arthritis in the knee by detecting active enthesitis not evident on prior conventional CT and X-ray images [36]. Ultimately, the image-processing technique of iodine mapping can improve iodine contrast resolution and more clearly illustrate the various patterns of inflammation in psoriatic arthritis on DECT [37].…”

Section: Inflammatory Arthropathiesmentioning

confidence: 98%

Updates on the Applications of Spectral Computed Tomography for Musculoskeletal Imaging

Eibschutz,

Matcuk,

Chiu

et al. 2024

Diagnostics

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Spectral CT represents a novel imaging approach that can noninvasively visualize, quantify, and characterize many musculoskeletal pathologies. This modality has revolutionized the field of radiology by capturing CT attenuation data across multiple energy levels and offering superior tissue characterization while potentially minimizing radiation exposure compared to traditional enhanced CT scans. Despite MRI being the preferred imaging method for many musculoskeletal conditions, it is not viable for some patients. Moreover, this technique is time-consuming, costly, and has limited availability in many healthcare settings. Thus, spectral CT has a considerable role in improving the diagnosis, characterization, and treatment of gout, inflammatory arthropathies, degenerative disc disease, osteoporosis, occult fractures, malignancies, ligamentous injuries, and other bone-marrow pathologies. This comprehensive review will delve into the diverse capabilities of dual-energy CT, a subset of spectral CT, in addressing these musculoskeletal conditions and explore potential future avenues for its integration into clinical practice.

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Usefulness of dual‐energy computed tomography for the evaluation of psoriatic arthritis accompanied by knee osteoarthritis

Cited by 2 publications

References 4 publications

Interleukin-17A and Keratinocytes in Psoriasis

Interleukin-17A and Keratinocytes in Psoriasis

Updates on the Applications of Spectral Computed Tomography for Musculoskeletal Imaging

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