Usefulness of Early Treatment With Melatonin to Reduce Infarct Size in Patients With ST-Segment Elevation Myocardial Infarction Receiving Percutaneous Coronary Intervention (From the Melatonin Adjunct in the Acute Myocardial Infarction Treated With Angioplasty Trial)

Domínguez‐Rodríguez, Alberto; Abreu-González, Pedro; Torre-Hernández, José M. de la; Consuegra-Sánchez, Luciano; Piccolo, Raffaele; Gonzalez-Gonzalez, Julia; García-Camarero, Tamara; Garcia-Saiz, Maria del Mar; Aldea-Perona, Ana; Reíter, Russel J.; Caballero-Estevez, Natalia; Rosa, Alejandro de la; Virgos-Aller, Tirso; Nazco-Casariego, Julia; Laynez‐Cerdeña, Ignacio; Bosa‐Ojeda, Francisco; Sanchez-Grande, Alejandro; Yanes-Bowden, Geoffrey; Vargas-Torres, Manuel J.; Lara-Padrón, Antonio; Perez-Jorge, Pablo; Díaz‐Flores, Lucio; Lopez, J; Lacalzada‐Almeida, Juan; Duque, Amelia; Bethencourt, Miguel; Izquierdo, Mariela; Juarez-Prera, Ruben; Blanco-Palacios, Gabriela; Barragán-Acea, Antonio; Ferrer-Hita, Julio J.; Marí‐López, Belén; Padilla, Marta; Gonzalez, E.; Martín-Cabeza, Marta María; Mendez-Vargas, Corabel; Barrios, Patrícia; Belleyo‐Belkasem, Carima; Leiva, Miguel A.; Betancor, Iván Hernández; Miranda, Julio; Poderós, Teresa Giménez; Soria-Arcos, Federico; Martinez, Lourdes

doi:10.1016/j.amjcard.2017.05.018

Cited by 67 publications

(78 citation statements)

References 19 publications

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“…The usefulness of melatonin treatment for cardiovascular diseases has been reported . Melatonin supplementation protected against pathological cardiac remodeling induced by transverse aortic constriction and isoproterenol, and melatonin prevented mitochondrial fission and improved cardiac function in mice with diabetes through the SIRT1‐PGC1α pathway .…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin supplementation protected against pathological cardiac remodeling induced by transverse aortic constriction and isoproterenol, and melatonin prevented mitochondrial fission and improved cardiac function in mice with diabetes through the SIRT1‐PGC1α pathway . Administration of melatonin in AMI patients with ST elevation, who presented early after symptom onset, was associated with a significant reduction in the infarct size and remodeling after primary percutaneous coronary intervention . Although the causality between the decrease in melatonin level in the patients and low cardiac output in DCM patients remains to be elucidated, the decreased melatonin production might be causally related to the development of cardiac remodeling in DCM patients.…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin supplementation seems to protect CAD or LV reverse remodeling. Although intracoronary and intravenous melatonin did not appear to attenuate reperfusion injury, or myocardial infarct size which was assessed by cardiac magnetic resonance imaging (the myocardial salvage index), after primary percutaneous coronary intervention in AMI patients with ST elevation compared with placebo (MARIA trial), the post hoc analysis showed that those presenting within 2.5 hours of symptom onset showed a significant reduction in myocardial infarct size and LV remodeling …”

Section: Introductionmentioning

confidence: 99%

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Plasma levels of melatonin in dilated cardiomyopathy

Misaka

Yoshihisa

Yokokawa

et al. 2019

Journal of Pineal Research

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Background Melatonin is a multifunctional indolamine and has a cardioprotective role in a variety of cardiovascular processes via antioxidant, anti‐inflammatory, antihypertensive, antithrombotic, and antilipemic effects. It has been reported that lower levels of circulating melatonin are significantly associated with a higher risk of acute myocardial infarction (AMI) and later cardiac remodeling. However, levels of melatonin in patients with dilated cardiomyopathy (DCM) and associations between melatonin levels and cardiac function remain unclear. Methods and Results We measured and compared plasma levels of melatonin in 61 control subjects, 81 AMI patients, and 77 DCM patients. Plasma levels of melatonin were progressively decreased from 71.9 pg/mL in the control group to 52.6 pg/mL in the DCM group and 21.9 pg/mL in the AMI group. Next, we examined associations of melatonin levels with parameters of laboratory data, echocardiography, and right‐heart catheterization. In the DCM patients, circulating melatonin showed significant correlations with both high‐sensitivity troponin T ( R = −0.422, P < 0.001) and cardiac output ( R = 0.431, P = 0.003), but not with B‐type natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), pulmonary artery wedge pressure, or pulmonary artery pressure. Conclusion Patients with not only AMI but also DCM had lower circulating melatonin levels. Circulating melatonin levels appear to correlate with myocardial injury and cardiac output in DCM patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma levels of melatonin in dilated cardiomyopathy

Misaka

Yoshihisa

Yokokawa

et al. 2019

Journal of Pineal Research

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“…For instance, Dominguez-Rodriguez et al 2 found no beneficial effects on cardiovascular system in patients with ST-elevation myocardial infarction. In contrast, a post hoc subgroup analysis in the same study 3 showed beneficial effects of melatonin in patients with ST-elevation myocardial infarction who received treatments ≤2.5 hours after symptom onset. Moreover, a daily administration of 1.5 mg melatonin was also found to attenuate blood pressure and its daily variation in elder subjects.…”

Section: Huichu LI Ms Jing Cai Phd Haidong Kan Phdmentioning

confidence: 85%

Response by Li et al to Letters Regarding Article, “Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification”

Cai

Kan

2018

Circulation

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“…An additional small percentage of the total number of published reports substantiating the ability of melatonin to limit oxidative stress under conditions that would have otherwise had disastrous consequences are summarized in Table 1 [69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100]. …”

Section: Melatonin: Harnessing Free Radicalsmentioning

confidence: 99%

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

Reíter

Tan

Rosales-Corral

et al. 2018

IJMS

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Melatonin exhibits extraordinary diversity in terms of its functions and distribution. When discovered, it was thought to be uniquely of pineal gland origin. Subsequently, melatonin synthesis was identified in a variety of organs and recently it was shown to be produced in the mitochondria. Since mitochondria exist in every cell, with a few exceptions, it means that every vertebrate, invertebrate, and plant cell produces melatonin. The mitochondrial synthesis of melatonin is not photoperiod-dependent, but it may be inducible under conditions of stress. Mitochondria-produced melatonin is not released into the systemic circulation, but rather is used primarily in its cell of origin. Melatonin’s functions in the mitochondria are highly diverse, not unlike those of sirtuin 3 (SIRT3). SIRT3 is an NAD+-dependent deacetylase which regulates, among many functions, the redox state of the mitochondria. Recent data proves that melatonin and SIRT3 post-translationally collaborate in regulating free radical generation and removal from mitochondria. Since melatonin and SIRT3 have cohabitated in the mitochondria for many eons, we predict that these molecules interact in many other ways to control mitochondrial physiology. It is predicted that these mutual functions will be intensely investigated in the next decade and importantly, we assume that the findings will have significant applications for preventing/delaying some age-related diseases and aging itself.

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Usefulness of Early Treatment With Melatonin to Reduce Infarct Size in Patients With ST-Segment Elevation Myocardial Infarction Receiving Percutaneous Coronary Intervention (From the Melatonin Adjunct in the Acute Myocardial Infarction Treated With Angioplasty Trial)

Cited by 67 publications

References 19 publications

Plasma levels of melatonin in dilated cardiomyopathy

Plasma levels of melatonin in dilated cardiomyopathy

Response by Li et al to Letters Regarding Article, “Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification”

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

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